[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100059043":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":12,"centralContacts":7,"locations":23,"responsibleParty":7,"collaborators":7,"id":281,"slug":282,"hasResults":283,"nctId":284,"briefTitle":285,"officialTitle":286,"acronym":7,"eligibilityCriteria":287,"healthyVolunteers":283,"sex":288,"minAge":289,"maxAge":7,"enrollmentInfo":290,"targetDuration":7,"studyType":293,"phases":294,"briefSummary":296,"conditions":297,"keywords":299,"overallStatus":307,"whyStopped":7,"lastUpdateSubmitDate":308,"lastUpdatePostDateStruct":309,"startDateStruct":7,"completionDateStruct":7,"leadSponsor":312,"locationsCount":313},{"fullName":5,"class":6},"National Institute of Allergy and Infectious Diseases (NIAID)","NIH",null,[9],{"type":10,"name":11,"description":7,"armGroupLabels":7,"otherNames":7},"BEHAVIORAL","Antiretroviral Treatment Interruption",[13,17,20],{"name":14,"affiliation":15,"role":16},"Constance A Benson, MD","University of Colorado, Denver","STUDY_CHAIR",{"name":18,"affiliation":19,"role":16},"John Mellors, MD","University of Pittsburgh",{"name":21,"affiliation":22,"role":16},"Diane Havlir, MD","University of California, San Francisco",[24,37,47,56,65,74,79,89,99,109,119,124,134,140,145,155,165,173,179,185,191,197,206,211,221,231,241,250,260,270],{"facility":25,"status":7,"city":26,"state":27,"zip":28,"country":29,"countryCode":30,"cosmosGeoPoint":31,"geoPoint":36,"contacts":7},"Univ of Alabama at Birmingham","Birmingham","Alabama","35294","United States","US",{"type":32,"coordinates":33},"Point",[34,35],-86.80249,33.52066,{"lat":35,"lon":34},{"facility":38,"status":7,"city":39,"state":40,"zip":41,"country":29,"countryCode":30,"cosmosGeoPoint":42,"geoPoint":46,"contacts":7},"UCLA CARE Ctr","Los Angeles","California","90095",{"type":32,"coordinates":43},[44,45],-118.24368,34.05223,{"lat":45,"lon":44},{"facility":48,"status":7,"city":49,"state":40,"zip":50,"country":29,"countryCode":30,"cosmosGeoPoint":51,"geoPoint":55,"contacts":7},"Willow Clinic","Menlo Park","94025",{"type":32,"coordinates":52},[53,54],-122.18219,37.45383,{"lat":54,"lon":53},{"facility":57,"status":7,"city":58,"state":40,"zip":59,"country":29,"countryCode":30,"cosmosGeoPoint":60,"geoPoint":64,"contacts":7},"Univ of California, San Diego","San Diego","92103",{"type":32,"coordinates":61},[62,63],-117.16472,32.71571,{"lat":63,"lon":62},{"facility":66,"status":7,"city":67,"state":40,"zip":68,"country":29,"countryCode":30,"cosmosGeoPoint":69,"geoPoint":73,"contacts":7},"San Mateo AIDS Program \u002F Stanford Univ","Stanford","943055107",{"type":32,"coordinates":70},[71,72],-122.16608,37.42411,{"lat":72,"lon":71},{"facility":75,"status":7,"city":67,"state":40,"zip":68,"country":29,"countryCode":30,"cosmosGeoPoint":76,"geoPoint":78,"contacts":7},"Stanford Univ Med Ctr",{"type":32,"coordinates":77},[71,72],{"lat":72,"lon":71},{"facility":80,"status":7,"city":81,"state":82,"zip":83,"country":29,"countryCode":30,"cosmosGeoPoint":84,"geoPoint":88,"contacts":7},"Univ of Colorado Health Sciences Ctr","Denver","Colorado","80262",{"type":32,"coordinates":85},[86,87],-104.9847,39.73915,{"lat":87,"lon":86},{"facility":90,"status":7,"city":91,"state":92,"zip":93,"country":29,"countryCode":30,"cosmosGeoPoint":94,"geoPoint":98,"contacts":7},"Univ of Miami School of Medicine","Miami","Florida","331361013",{"type":32,"coordinates":95},[96,97],-80.19366,25.77427,{"lat":97,"lon":96},{"facility":100,"status":7,"city":101,"state":102,"zip":103,"country":29,"countryCode":30,"cosmosGeoPoint":104,"geoPoint":108,"contacts":7},"Univ of Hawaii","Honolulu","Hawaii","96816",{"type":32,"coordinates":105},[106,107],-157.85833,21.30694,{"lat":107,"lon":106},{"facility":110,"status":7,"city":111,"state":112,"zip":113,"country":29,"countryCode":30,"cosmosGeoPoint":114,"geoPoint":118,"contacts":7},"Rush Presbyterian - Saint Luke's Med Ctr","Chicago","Illinois","60612",{"type":32,"coordinates":115},[116,117],-87.65005,41.85003,{"lat":117,"lon":116},{"facility":120,"status":7,"city":111,"state":112,"zip":113,"country":29,"countryCode":30,"cosmosGeoPoint":121,"geoPoint":123,"contacts":7},"The CORE Ctr",{"type":32,"coordinates":122},[116,117],{"lat":117,"lon":116},{"facility":125,"status":7,"city":126,"state":127,"zip":128,"country":29,"countryCode":30,"cosmosGeoPoint":129,"geoPoint":133,"contacts":7},"Indiana Univ Hosp","Indianapolis","Indiana","462025250",{"type":32,"coordinates":130},[131,132],-86.15804,39.76838,{"lat":132,"lon":131},{"facility":135,"status":7,"city":126,"state":127,"zip":136,"country":29,"countryCode":30,"cosmosGeoPoint":137,"geoPoint":139,"contacts":7},"Methodist Hosp of Indiana \u002F Life Care Clinic","46202",{"type":32,"coordinates":138},[131,132],{"lat":132,"lon":131},{"facility":141,"status":7,"city":126,"state":127,"zip":136,"country":29,"countryCode":30,"cosmosGeoPoint":142,"geoPoint":144,"contacts":7},"Wishard Hosp",{"type":32,"coordinates":143},[131,132],{"lat":132,"lon":131},{"facility":146,"status":7,"city":147,"state":148,"zip":149,"country":29,"countryCode":30,"cosmosGeoPoint":150,"geoPoint":154,"contacts":7},"Beth Israel Deaconess - West Campus","Boston","Massachusetts","02215",{"type":32,"coordinates":151},[152,153],-71.05977,42.35843,{"lat":153,"lon":152},{"facility":156,"status":7,"city":157,"state":158,"zip":159,"country":29,"countryCode":30,"cosmosGeoPoint":160,"geoPoint":164,"contacts":7},"SUNY \u002F Erie County Med Ctr at Buffalo","Buffalo","New York","14215",{"type":32,"coordinates":161},[162,163],-78.87837,42.88645,{"lat":163,"lon":162},{"facility":166,"status":7,"city":158,"state":158,"zip":167,"country":29,"countryCode":30,"cosmosGeoPoint":168,"geoPoint":172,"contacts":7},"Beth Israel Med Ctr","10003",{"type":32,"coordinates":169},[170,171],-74.00597,40.71427,{"lat":171,"lon":170},{"facility":174,"status":7,"city":158,"state":158,"zip":175,"country":29,"countryCode":30,"cosmosGeoPoint":176,"geoPoint":178,"contacts":7},"Cornell Clinical Trials Unit - Chelsea Clinic","10011",{"type":32,"coordinates":177},[170,171],{"lat":171,"lon":170},{"facility":180,"status":7,"city":158,"state":158,"zip":181,"country":29,"countryCode":30,"cosmosGeoPoint":182,"geoPoint":184,"contacts":7},"Bellevue Hosp \u002F New York Univ Med Ctr","10016",{"type":32,"coordinates":183},[170,171],{"lat":171,"lon":170},{"facility":186,"status":7,"city":158,"state":158,"zip":187,"country":29,"countryCode":30,"cosmosGeoPoint":188,"geoPoint":190,"contacts":7},"Cornell Univ Med Ctr","10021",{"type":32,"coordinates":189},[170,171],{"lat":171,"lon":170},{"facility":192,"status":7,"city":158,"state":158,"zip":193,"country":29,"countryCode":30,"cosmosGeoPoint":194,"geoPoint":196,"contacts":7},"Columbia Presbyterian Med Ctr","10032",{"type":32,"coordinates":195},[170,171],{"lat":171,"lon":170},{"facility":198,"status":7,"city":199,"state":158,"zip":200,"country":29,"countryCode":30,"cosmosGeoPoint":201,"geoPoint":205,"contacts":7},"Community Health Network Inc","Rochester","14642",{"type":32,"coordinates":202},[203,204],-77.61556,43.15478,{"lat":204,"lon":203},{"facility":207,"status":7,"city":199,"state":158,"zip":200,"country":29,"countryCode":30,"cosmosGeoPoint":208,"geoPoint":210,"contacts":7},"Univ of Rochester Medical Center",{"type":32,"coordinates":209},[203,204],{"lat":204,"lon":203},{"facility":212,"status":7,"city":213,"state":214,"zip":215,"country":29,"countryCode":30,"cosmosGeoPoint":216,"geoPoint":220,"contacts":7},"Duke Univ Med Ctr","Durham","North Carolina","27710",{"type":32,"coordinates":217},[218,219],-78.89862,35.99403,{"lat":219,"lon":218},{"facility":222,"status":7,"city":223,"state":224,"zip":225,"country":29,"countryCode":30,"cosmosGeoPoint":226,"geoPoint":230,"contacts":7},"Univ of Cincinnati","Cincinnati","Ohio","452670405",{"type":32,"coordinates":227},[228,229],-84.51439,39.12711,{"lat":229,"lon":228},{"facility":232,"status":7,"city":233,"state":234,"zip":235,"country":29,"countryCode":30,"cosmosGeoPoint":236,"geoPoint":240,"contacts":7},"Univ of Pennsylvania","Philadelphia","Pennsylvania","19104",{"type":32,"coordinates":237},[238,239],-75.16362,39.95238,{"lat":239,"lon":238},{"facility":242,"status":7,"city":243,"state":234,"zip":244,"country":29,"countryCode":30,"cosmosGeoPoint":245,"geoPoint":249,"contacts":7},"Univ of Pittsburgh","Pittsburgh","15213",{"type":32,"coordinates":246},[247,248],-79.99589,40.44062,{"lat":248,"lon":247},{"facility":251,"status":7,"city":252,"state":253,"zip":254,"country":29,"countryCode":30,"cosmosGeoPoint":255,"geoPoint":259,"contacts":7},"Vanderbilt Univ Med Ctr","Nashville","Tennessee","37203",{"type":32,"coordinates":256},[257,258],-86.78444,36.16589,{"lat":258,"lon":257},{"facility":261,"status":7,"city":262,"state":263,"zip":264,"country":29,"countryCode":30,"cosmosGeoPoint":265,"geoPoint":269,"contacts":7},"Children's Med Ctr of Dallas","Dallas","Texas","75235",{"type":32,"coordinates":266},[267,268],-96.80667,32.78306,{"lat":268,"lon":267},{"facility":271,"status":7,"city":272,"state":7,"zip":273,"country":274,"countryCode":275,"cosmosGeoPoint":276,"geoPoint":280,"contacts":7},"Univ of Puerto Rico","San Juan","009365067","Puerto Rico","PR",{"type":32,"coordinates":277},[278,279],-66.10572,18.46633,{"lat":279,"lon":278},"100059043","phase-3-salvage-treatment-resistance-testing-and-withdrawal-of-anti-hiv-drugs-for-hiv-patients-failing-current-anti-hiv-treatment-100059043",false,"NCT00011128","Salvage Treatment, Resistance Testing, and Withdrawal of Anti-HIV Drugs for HIV Patients Failing Current Anti-HIV Treatment","Phase III Evaluation of the Role of Temporary Cessation of Antiretroviral Treatment and Resistance Testing-Based Selection of Antiretroviral Drugs in the Virologic Response to Salvage Therapy for Heavily Treatment-Experienced HIV-Infected Individuals Failing Current Antiretroviral Therapy","Inclusion Criteria\n\nPatients may be eligible for this study if they:\n\n* Are HIV-infected.\n* Are likely to have drug-resistant HIV from having taken all types of anti-HIV drugs (protease inhibitors \\[PIs\\], nucleoside reverse transcriptase inhibitors \\[NRTIs\\], and nonnucleoside reverse transcriptase inhibitors \\[NNRTIs\\]), and having failed treatment prior to the current treatment for reasons other than toxicity.\n* Are currently receiving anti-HIV treatment with at least 3 drugs. Low doses of ritonavir (100 to 200 mg twice daily) taken with 1 other PI is counted as a single PI.\n* Are currently failing treatment due to a high viral load (amount of HIV in the blood).\n* Have had a new anti-HIV drug combination selected.\n* Are at least 18 years old.\n* This study has been changed to remove CD4 counts as an inclusion criterion. In the previous version of the protocol, patients were required to have a CD4 count of 150 cells\u002Fml or more within 42 days prior to study entry.\n\nExclusion Criteria\n\nPatients will not be eligible for this study if they:\n\n* Have stopped treatment for more than 4 weeks in the past 6 months.\n* Are pregnant or breast-feeding.\n* Have cancer that requires systemic treatment or radiation.\n* Have received the following medications affecting the immune system within 14 days before entry: erythropoietin; Granulocyte Colony Stimulating Factor (G-CSF), including Granulocyte Macrophage Colony Stimulating Factors (GM-CSF); interleukins; or therapeutic HIV vaccines.","ALL","18 Years",{"count":291,"type":292},0,"ACTUAL","INTERVENTIONAL",[295],"PHASE3","The purpose of this study is to test another way to control the amount of HIV in the blood (viral load).\n\nStudies show that stopping all anti-HIV drugs for a time before switching to new anti-HIV drugs may improve the response in some individuals who are failing treatment. Other studies suggest a benefit if drug-resistance tests are used in selecting a new anti-HIV drug treatment. This study tests the effect of stopping anti-HIV drugs for a time before switching to anti-HIV drugs selected using drug-resistance test results.",[298],"HIV Infections",[300,301,302,303,304,305,306],"HIV-1","Drug Resistance, Microbial","Microbial Sensitivity Tests","Salvage Therapy","Anti-HIV Agents","Viral Load","Treatment Experienced","WITHDRAWN","2015-05-15",{"date":310,"type":311},"2015-05-18","ESTIMATED",{"name":5,"class":6},30]