[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100160395":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":25,"locations":32,"responsibleParty":562,"collaborators":25,"id":564,"slug":565,"hasResults":566,"nctId":567,"briefTitle":568,"officialTitle":569,"acronym":570,"eligibilityCriteria":571,"healthyVolunteers":572,"sex":573,"minAge":574,"maxAge":575,"enrollmentInfo":576,"targetDuration":25,"studyType":579,"phases":580,"briefSummary":582,"conditions":583,"keywords":589,"overallStatus":594,"whyStopped":25,"lastUpdateSubmitDate":595,"lastUpdatePostDateStruct":596,"startDateStruct":599,"completionDateStruct":601,"leadSponsor":603,"locationsCount":604},{"fullName":5,"class":6},"Otsuka Pharmaceutical Development & Commercialization, Inc.","INDUSTRY",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Phase B","EXPERIMENTAL","Drug: OPC-34712 + ADT\n\nDrug: Placebo + ADT",[13,14],"Drug: OPC-34712 + ADT","Drug: Placebo + ADT",{"label":16,"type":17,"description":14,"interventionNames":18},"Phase A","PLACEBO_COMPARATOR",[14],[20,26,30],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","OPC-34712 + ADT","Tablets, Oral, 1 or 3 mg OPC-34712 and FDA Approved Antidepressant Therapy (ADT)",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Placebo + ADT","Placebo + FDA Approved Antidepressant (ADT)",[9],{"type":21,"name":27,"description":28,"armGroupLabels":31,"otherNames":25},[16],[33,45,53,60,67,74,81,89,96,103,110,117,125,132,140,147,155,163,171,179,186,194,202,210,218,225,233,240,246,253,261,269,276,283,291,299,306,314,321,329,337,345,353,360,367,374,376,384,391,399,406,414,421,431,439,449,457,465,472,482,489,496,505,507,514,523,530,537,541,548,555],{"facility":34,"status":25,"city":35,"state":36,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":25},"Research Site","Birmingham","Alabama","United States","US",{"type":40,"coordinates":41},"Point",[42,43],-86.80249,33.52066,{"lat":43,"lon":42},{"facility":34,"status":25,"city":46,"state":47,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":48,"geoPoint":52,"contacts":25},"Costa Mesa","California",{"type":40,"coordinates":49},[50,51],-117.91867,33.64113,{"lat":51,"lon":50},{"facility":34,"status":25,"city":54,"state":47,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":55,"geoPoint":59,"contacts":25},"Glendale",{"type":40,"coordinates":56},[57,58],-118.25508,34.14251,{"lat":58,"lon":57},{"facility":34,"status":25,"city":61,"state":47,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":62,"geoPoint":66,"contacts":25},"Orange",{"type":40,"coordinates":63},[64,65],-117.85311,33.78779,{"lat":65,"lon":64},{"facility":34,"status":25,"city":68,"state":47,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":69,"geoPoint":73,"contacts":25},"San Diego",{"type":40,"coordinates":70},[71,72],-117.16472,32.71571,{"lat":72,"lon":71},{"facility":34,"status":25,"city":75,"state":47,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":76,"geoPoint":80,"contacts":25},"Temecula",{"type":40,"coordinates":77},[78,79],-117.14836,33.49364,{"lat":79,"lon":78},{"facility":34,"status":25,"city":82,"state":83,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":84,"geoPoint":88,"contacts":25},"Jacksonville","Florida",{"type":40,"coordinates":85},[86,87],-81.65565,30.33218,{"lat":87,"lon":86},{"facility":34,"status":25,"city":90,"state":83,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":91,"geoPoint":95,"contacts":25},"Jacksonville Beach",{"type":40,"coordinates":92},[93,94],-81.39314,30.29469,{"lat":94,"lon":93},{"facility":34,"status":25,"city":97,"state":83,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":98,"geoPoint":102,"contacts":25},"Miami Springs",{"type":40,"coordinates":99},[100,101],-80.2895,25.82232,{"lat":101,"lon":100},{"facility":34,"status":25,"city":104,"state":83,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":105,"geoPoint":109,"contacts":25},"Tampa",{"type":40,"coordinates":106},[107,108],-82.45843,27.94752,{"lat":108,"lon":107},{"facility":34,"status":25,"city":111,"state":83,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":112,"geoPoint":116,"contacts":25},"Winter Park",{"type":40,"coordinates":113},[114,115],-81.33924,28.6,{"lat":115,"lon":114},{"facility":34,"status":25,"city":118,"state":119,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":120,"geoPoint":124,"contacts":25},"Atlanta","Georgia",{"type":40,"coordinates":121},[122,123],-84.38798,33.749,{"lat":123,"lon":122},{"facility":34,"status":25,"city":126,"state":119,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":127,"geoPoint":131,"contacts":25},"Smyrna",{"type":40,"coordinates":128},[129,130],-84.51438,33.88399,{"lat":130,"lon":129},{"facility":34,"status":25,"city":133,"state":134,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":135,"geoPoint":139,"contacts":25},"Chicago","Illinois",{"type":40,"coordinates":136},[137,138],-87.65005,41.85003,{"lat":138,"lon":137},{"facility":34,"status":25,"city":141,"state":134,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":142,"geoPoint":146,"contacts":25},"Oak Brook",{"type":40,"coordinates":143},[144,145],-87.92895,41.83281,{"lat":145,"lon":144},{"facility":34,"status":25,"city":148,"state":149,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":150,"geoPoint":154,"contacts":25},"Lafayette","Indiana",{"type":40,"coordinates":151},[152,153],-86.87529,40.4167,{"lat":153,"lon":152},{"facility":34,"status":25,"city":156,"state":157,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":158,"geoPoint":162,"contacts":25},"Owensboro","Kentucky",{"type":40,"coordinates":159},[160,161],-87.11333,37.77422,{"lat":161,"lon":160},{"facility":34,"status":25,"city":164,"state":165,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":166,"geoPoint":170,"contacts":25},"Baltimore","Maryland",{"type":40,"coordinates":167},[168,169],-76.61219,39.29038,{"lat":169,"lon":168},{"facility":34,"status":25,"city":172,"state":173,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":174,"geoPoint":178,"contacts":25},"Haverhill","Massachusetts",{"type":40,"coordinates":175},[176,177],-71.07728,42.7762,{"lat":177,"lon":176},{"facility":34,"status":25,"city":180,"state":173,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":181,"geoPoint":185,"contacts":25},"Weymouth",{"type":40,"coordinates":182},[183,184],-70.93977,42.22093,{"lat":184,"lon":183},{"facility":34,"status":25,"city":187,"state":188,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":189,"geoPoint":193,"contacts":25},"Rochester Hills","Michigan",{"type":40,"coordinates":190},[191,192],-83.14993,42.65837,{"lat":192,"lon":191},{"facility":34,"status":25,"city":195,"state":196,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":197,"geoPoint":201,"contacts":25},"Creve Coeur","Missouri",{"type":40,"coordinates":198},[199,200],-90.42262,38.66089,{"lat":200,"lon":199},{"facility":34,"status":25,"city":203,"state":204,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":205,"geoPoint":209,"contacts":25},"Las Vegas","Nevada",{"type":40,"coordinates":206},[207,208],-115.13722,36.17497,{"lat":208,"lon":207},{"facility":34,"status":25,"city":211,"state":212,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":213,"geoPoint":217,"contacts":25},"Cherry Hill","New Jersey",{"type":40,"coordinates":214},[215,216],-75.03073,39.93484,{"lat":216,"lon":215},{"facility":34,"status":25,"city":219,"state":212,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":220,"geoPoint":224,"contacts":25},"Toms River",{"type":40,"coordinates":221},[222,223],-74.19792,39.95373,{"lat":223,"lon":222},{"facility":34,"status":25,"city":226,"state":227,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":228,"geoPoint":232,"contacts":25},"Brooklyn","New York",{"type":40,"coordinates":229},[230,231],-73.94958,40.6501,{"lat":231,"lon":230},{"facility":34,"status":25,"city":234,"state":227,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":235,"geoPoint":239,"contacts":25},"Fresh Meadows",{"type":40,"coordinates":236},[237,238],-73.79347,40.73482,{"lat":238,"lon":237},{"facility":34,"status":25,"city":227,"state":227,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":241,"geoPoint":245,"contacts":25},{"type":40,"coordinates":242},[243,244],-74.00597,40.71427,{"lat":244,"lon":243},{"facility":34,"status":25,"city":247,"state":227,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":248,"geoPoint":252,"contacts":25},"Staten Island",{"type":40,"coordinates":249},[250,251],-74.13986,40.56233,{"lat":251,"lon":250},{"facility":34,"status":25,"city":254,"state":255,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":256,"geoPoint":260,"contacts":25},"Raleigh","North Carolina",{"type":40,"coordinates":257},[258,259],-78.63861,35.7721,{"lat":259,"lon":258},{"facility":34,"status":25,"city":262,"state":263,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":264,"geoPoint":268,"contacts":25},"Beachwood","Ohio",{"type":40,"coordinates":265},[266,267],-81.50873,41.4645,{"lat":267,"lon":266},{"facility":34,"status":25,"city":270,"state":263,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":271,"geoPoint":275,"contacts":25},"Cincinnati",{"type":40,"coordinates":272},[273,274],-84.51439,39.12711,{"lat":274,"lon":273},{"facility":34,"status":25,"city":277,"state":263,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":278,"geoPoint":282,"contacts":25},"Columbus",{"type":40,"coordinates":279},[280,281],-82.99879,39.96118,{"lat":281,"lon":280},{"facility":34,"status":25,"city":284,"state":285,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":286,"geoPoint":290,"contacts":25},"Oklahoma City","Oklahoma",{"type":40,"coordinates":287},[288,289],-97.51643,35.46756,{"lat":289,"lon":288},{"facility":34,"status":25,"city":292,"state":293,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":294,"geoPoint":298,"contacts":25},"Portland","Oregon",{"type":40,"coordinates":295},[296,297],-122.67621,45.52345,{"lat":297,"lon":296},{"facility":25,"status":25,"city":300,"state":293,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":301,"geoPoint":305,"contacts":25},"Salem",{"type":40,"coordinates":302},[303,304],-123.0351,44.9429,{"lat":304,"lon":303},{"facility":34,"status":25,"city":307,"state":308,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":309,"geoPoint":313,"contacts":25},"Norristown","Pennsylvania",{"type":40,"coordinates":310},[311,312],-75.3399,40.1215,{"lat":312,"lon":311},{"facility":34,"status":25,"city":315,"state":308,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":316,"geoPoint":320,"contacts":25},"Philadelphia",{"type":40,"coordinates":317},[318,319],-75.16362,39.95238,{"lat":319,"lon":318},{"facility":34,"status":25,"city":322,"state":323,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":324,"geoPoint":328,"contacts":25},"Lincoln","Rhode Island",{"type":40,"coordinates":325},[326,327],-71.435,41.92111,{"lat":327,"lon":326},{"facility":34,"status":25,"city":330,"state":331,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":332,"geoPoint":336,"contacts":25},"Columbia","South Carolina",{"type":40,"coordinates":333},[334,335],-81.03481,34.00071,{"lat":335,"lon":334},{"facility":34,"status":25,"city":338,"state":339,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":340,"geoPoint":344,"contacts":25},"Memphis","Tennessee",{"type":40,"coordinates":341},[342,343],-90.04898,35.14953,{"lat":343,"lon":342},{"facility":34,"status":25,"city":346,"state":347,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":348,"geoPoint":352,"contacts":25},"Austin","Texas",{"type":40,"coordinates":349},[350,351],-97.74306,30.26715,{"lat":351,"lon":350},{"facility":34,"status":25,"city":354,"state":347,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":355,"geoPoint":359,"contacts":25},"Dallas",{"type":40,"coordinates":356},[357,358],-96.80667,32.78306,{"lat":358,"lon":357},{"facility":34,"status":25,"city":361,"state":347,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":362,"geoPoint":366,"contacts":25},"Houston",{"type":40,"coordinates":363},[364,365],-95.36327,29.76328,{"lat":365,"lon":364},{"facility":34,"status":25,"city":368,"state":347,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":369,"geoPoint":373,"contacts":25},"San Antonio",{"type":40,"coordinates":370},[371,372],-98.49363,29.42412,{"lat":372,"lon":371},{"facility":34,"status":25,"city":375,"state":347,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":25,"geoPoint":25,"contacts":25},"Witchita Falls",{"facility":34,"status":25,"city":377,"state":378,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":379,"geoPoint":383,"contacts":25},"Charlottesville","Virginia",{"type":40,"coordinates":380},[381,382],-78.47668,38.02931,{"lat":382,"lon":381},{"facility":34,"status":25,"city":385,"state":378,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":386,"geoPoint":390,"contacts":25},"Herndon",{"type":40,"coordinates":387},[388,389],-77.3861,38.96955,{"lat":389,"lon":388},{"facility":34,"status":25,"city":392,"state":393,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":394,"geoPoint":398,"contacts":25},"Bellevue","Washington",{"type":40,"coordinates":395},[396,397],-122.20068,47.61038,{"lat":397,"lon":396},{"facility":34,"status":25,"city":400,"state":393,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":401,"geoPoint":405,"contacts":25},"Spokane",{"type":40,"coordinates":402},[403,404],-117.42908,47.65966,{"lat":404,"lon":403},{"facility":34,"status":25,"city":407,"state":408,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":409,"geoPoint":413,"contacts":25},"Brown Deer","Wisconsin",{"type":40,"coordinates":410},[411,412],-87.96453,43.16334,{"lat":412,"lon":411},{"facility":34,"status":25,"city":415,"state":408,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":416,"geoPoint":420,"contacts":25},"Middleton",{"type":40,"coordinates":417},[418,419],-89.50429,43.09722,{"lat":419,"lon":418},{"facility":34,"status":25,"city":422,"state":423,"zip":25,"country":424,"countryCode":425,"cosmosGeoPoint":426,"geoPoint":430,"contacts":25},"Toronto","Ontario","Canada","CA",{"type":40,"coordinates":427},[428,429],-79.39864,43.70643,{"lat":429,"lon":428},{"facility":34,"status":25,"city":432,"state":433,"zip":25,"country":424,"countryCode":425,"cosmosGeoPoint":434,"geoPoint":438,"contacts":25},"Pointe-Claire","Quebec",{"type":40,"coordinates":435},[436,437],-73.81669,45.44868,{"lat":437,"lon":436},{"facility":34,"status":25,"city":440,"state":441,"zip":25,"country":442,"countryCode":443,"cosmosGeoPoint":444,"geoPoint":448,"contacts":25},"Würzburg","Bavaria","Germany","DE",{"type":40,"coordinates":445},[446,447],9.95121,49.79391,{"lat":447,"lon":446},{"facility":34,"status":25,"city":450,"state":451,"zip":25,"country":442,"countryCode":443,"cosmosGeoPoint":452,"geoPoint":456,"contacts":25},"Stralsund","Mecklenburg-Vorpommern",{"type":40,"coordinates":453},[454,455],13.0818,54.30911,{"lat":455,"lon":454},{"facility":34,"status":25,"city":458,"state":459,"zip":25,"country":442,"countryCode":443,"cosmosGeoPoint":460,"geoPoint":464,"contacts":25},"Bochum","North Rhine-Westphalia",{"type":40,"coordinates":461},[462,463],7.21648,51.48165,{"lat":463,"lon":462},{"facility":34,"status":25,"city":466,"state":25,"zip":25,"country":442,"countryCode":443,"cosmosGeoPoint":467,"geoPoint":471,"contacts":25},"Achim",{"type":40,"coordinates":468},[469,470],9.0263,53.01416,{"lat":470,"lon":469},{"facility":34,"status":25,"city":473,"state":474,"zip":25,"country":475,"countryCode":476,"cosmosGeoPoint":477,"geoPoint":481,"contacts":25},"Nyíregyháza","Szabolcs-Szatmár-Bereg","Hungary","HU",{"type":40,"coordinates":478},[479,480],21.71671,47.95539,{"lat":480,"lon":479},{"facility":34,"status":25,"city":483,"state":25,"zip":25,"country":475,"countryCode":476,"cosmosGeoPoint":484,"geoPoint":488,"contacts":25},"Budapest",{"type":40,"coordinates":485},[486,487],19.04045,47.49835,{"lat":487,"lon":486},{"facility":34,"status":25,"city":490,"state":25,"zip":25,"country":475,"countryCode":476,"cosmosGeoPoint":491,"geoPoint":495,"contacts":25},"Győr",{"type":40,"coordinates":492},[493,494],17.63512,47.68333,{"lat":494,"lon":493},{"facility":34,"status":25,"city":497,"state":25,"zip":25,"country":498,"countryCode":499,"cosmosGeoPoint":500,"geoPoint":504,"contacts":25},"Bucharest","Romania","RO",{"type":40,"coordinates":501},[502,503],26.10626,44.43225,{"lat":503,"lon":502},{"facility":34,"status":25,"city":506,"state":25,"zip":25,"country":498,"countryCode":499,"cosmosGeoPoint":25,"geoPoint":25,"contacts":25},"Lasi",{"facility":34,"status":25,"city":508,"state":25,"zip":25,"country":498,"countryCode":499,"cosmosGeoPoint":509,"geoPoint":513,"contacts":25},"Târgu Mureş",{"type":40,"coordinates":510},[511,512],24.55747,46.54245,{"lat":512,"lon":511},{"facility":34,"status":25,"city":515,"state":25,"zip":25,"country":516,"countryCode":517,"cosmosGeoPoint":518,"geoPoint":522,"contacts":25},"Moscow","Russia","RU",{"type":40,"coordinates":519},[520,521],37.61781,55.75204,{"lat":521,"lon":520},{"facility":34,"status":25,"city":524,"state":25,"zip":25,"country":516,"countryCode":517,"cosmosGeoPoint":525,"geoPoint":529,"contacts":25},"Rostov-on-Don",{"type":40,"coordinates":526},[527,528],39.70769,47.21997,{"lat":528,"lon":527},{"facility":34,"status":25,"city":531,"state":25,"zip":25,"country":516,"countryCode":517,"cosmosGeoPoint":532,"geoPoint":536,"contacts":25},"Saint Petersburg",{"type":40,"coordinates":533},[534,535],30.31413,59.93863,{"lat":535,"lon":534},{"facility":34,"status":25,"city":538,"state":25,"zip":25,"country":539,"countryCode":540,"cosmosGeoPoint":25,"geoPoint":25,"contacts":25},"Chenigiv","Ukraine","UA",{"facility":34,"status":25,"city":542,"state":25,"zip":25,"country":539,"countryCode":540,"cosmosGeoPoint":543,"geoPoint":547,"contacts":25},"Kharkiv",{"type":40,"coordinates":544},[545,546],36.25475,49.98177,{"lat":546,"lon":545},{"facility":34,"status":25,"city":549,"state":25,"zip":25,"country":539,"countryCode":540,"cosmosGeoPoint":550,"geoPoint":554,"contacts":25},"Kiev",{"type":40,"coordinates":551},[552,553],30.5238,50.45466,{"lat":553,"lon":552},{"facility":34,"status":25,"city":556,"state":25,"zip":25,"country":539,"countryCode":540,"cosmosGeoPoint":557,"geoPoint":561,"contacts":25},"Poltava",{"type":40,"coordinates":558},[559,560],34.55367,49.58925,{"lat":560,"lon":559},{"type":563,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100160395","phase-3-study-of-the-safety-and-efficacy-of-two-fixed-doses-of-opc-34712-as-adjunctive-therapy-in-the-treatment-of-adults-with-major-depressive-disorder-the-polaris-trial-100160395",true,"NCT01360632","Study of the Safety and Efficacy of Two Fixed Doses of OPC-34712 as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder (the Polaris Trial)","A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Trial of the Safety and Efficacy of Two Fixed Doses of OPDC-34712 as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder, the Polaris Trial","Polaris","Inclusion Criteria:\n\n* Male or female subjects between 18 and 65 years of age, with diagnosis of major depressive disorder, as defined by DSM-IV-TR criteria\n* The current depressive episode must be equal to or greater than 8 weeks in duration\n* Subjects must report a history for the current depressive episode of an inadequate response to no more than three adequate antidepressant treatments\n\nExclusion Criteria:\n\n* Females who are breast-feeding and\u002For who have a positive pregnancy test result prior to receiving study drug\n* Subjects who report an inadequate response to more than three adequate trials of antidepressant treatments during current depressive episode at a therapeutic dose for an adequate duration\n* Subjects with a current Axis I (DSM-IV-TR) diagnosis of: Delirium, dementia, amnestic or other cognitive disorder, Schizophrenia, schizoaffective disorder, or other psychotic disorder, Bipolar I or II disorder\n* Subjects with a clinically significant current Axis II (DSM-IV-TR) diagnosis of borderline, antisocial, paranoid, schizoid, schizotypal or histrionic personality disorder",false,"ALL","18 Years","65 Years",{"count":577,"type":578},1539,"ACTUAL","INTERVENTIONAL",[581],"PHASE3","To compare the effect of OPC-34712 (brexpiprazole) to the effect of placebo (an inactive substance) as add on treatment to an assigned FDA approved antidepressant treatment (ADT) in patients with Major Depressive Disorder who demonstrate an incomplete response to a prospective trial of the same assigned FDA approved ADT",[584,585,586,587,588],"Depressive Disorder","Depression","Depressive Disorder, Major","Mood Disorders","Mental Disorders",[590,591,592,593],"OPC-34712","brexpiprazole","Major Depressive Disorder","Adjunctive Treatment","COMPLETED","2015-11-30",{"date":597,"type":598},"2016-01-01","ESTIMATED",{"date":600,"type":25},"2011-06",{"date":602,"type":578},"2013-09",{"name":5,"class":6},71]