[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100273658":3},{"organization":4,"armGroups":7,"interventions":29,"overallOfficials":49,"centralContacts":45,"locations":53,"responsibleParty":785,"collaborators":45,"id":787,"slug":788,"hasResults":789,"nctId":790,"briefTitle":791,"officialTitle":792,"acronym":793,"eligibilityCriteria":794,"healthyVolunteers":789,"sex":795,"minAge":796,"maxAge":45,"enrollmentInfo":797,"targetDuration":45,"studyType":800,"phases":801,"briefSummary":803,"conditions":804,"keywords":45,"overallStatus":806,"whyStopped":45,"lastUpdateSubmitDate":807,"lastUpdatePostDateStruct":808,"startDateStruct":810,"completionDateStruct":812,"leadSponsor":815,"locationsCount":816},{"fullName":5,"class":6},"Gilead Sciences","INDUSTRY",[8,15,21,25],{"label":9,"type":10,"description":11,"interventionNames":12},"F\u002FTAF","EXPERIMENTAL","F\u002FTAF+ F\u002FTDF placebo for at least 96 weeks",[13,14],"Drug: F\u002FTAF","Drug: F\u002FTDF Placebo",{"label":16,"type":10,"description":17,"interventionNames":18},"F\u002FTDF","F\u002FTDF+ F\u002FTAF placebo for at least 96 weeks",[19,20],"Drug: F\u002FTDF","Drug: F\u002FTAF Placebo",{"label":22,"type":10,"description":23,"interventionNames":24},"Open-label","Once all participants have been on blinded treatment for at least 96 weeks, the study will be unblinded and participants will be offered the option to continue on open-label F\u002FTAF treatment for 96 weeks.",[13],{"label":26,"type":10,"description":27,"interventionNames":28},"Open-Label Extension","Participants who remain on study at Open-label Week 96 will have the option to continue on open-label F\u002FTAF treatment in the Open-label extension phase for 408 weeks.",[13],[30,36,41,46],{"type":31,"name":9,"description":32,"armGroupLabels":33,"otherNames":34},"DRUG","200\u002F25 mg tablet administered orally once daily",[9,26,22],[35],"Descovy®",{"type":31,"name":16,"description":37,"armGroupLabels":38,"otherNames":39},"200\u002F300 mg tablet administered orally once daily",[16],[40],"Truvada®",{"type":31,"name":42,"description":43,"armGroupLabels":44,"otherNames":45},"F\u002FTAF Placebo","Tablet administered orally once daily",[16],null,{"type":31,"name":47,"description":43,"armGroupLabels":48,"otherNames":45},"F\u002FTDF Placebo",[9],[50],{"name":51,"affiliation":5,"role":52},"Gilead Study Director","STUDY_DIRECTOR",[54,66,74,79,87,95,103,108,116,124,129,134,142,151,159,168,177,182,191,196,204,212,220,228,236,245,250,255,263,272,277,286,295,303,312,320,329,338,347,356,364,369,374,382,391,399,408,417,426,434,439,447,456,461,470,480,488,499,508,517,522,527,538,547,556,564,575,584,592,597,608,616,621,629,639,644,654,662,671,682,689,697,705,716,724,733,742,750,757,762,767,772,777],{"facility":45,"status":45,"city":55,"state":56,"zip":57,"country":58,"countryCode":59,"cosmosGeoPoint":60,"geoPoint":65,"contacts":45},"Beverly Hills","California","90211","United States","US",{"type":61,"coordinates":62},"Point",[63,64],-118.40036,34.07362,{"lat":64,"lon":63},{"facility":45,"status":45,"city":67,"state":56,"zip":68,"country":58,"countryCode":59,"cosmosGeoPoint":69,"geoPoint":73,"contacts":45},"Los Angeles","90036",{"type":61,"coordinates":70},[71,72],-118.24368,34.05223,{"lat":72,"lon":71},{"facility":45,"status":45,"city":67,"state":56,"zip":75,"country":58,"countryCode":59,"cosmosGeoPoint":76,"geoPoint":78,"contacts":45},"90069",{"type":61,"coordinates":77},[71,72],{"lat":72,"lon":71},{"facility":45,"status":45,"city":80,"state":56,"zip":81,"country":58,"countryCode":59,"cosmosGeoPoint":82,"geoPoint":86,"contacts":45},"Newport Beach","92663",{"type":61,"coordinates":83},[84,85],-117.92895,33.61891,{"lat":85,"lon":84},{"facility":45,"status":45,"city":88,"state":56,"zip":89,"country":58,"countryCode":59,"cosmosGeoPoint":90,"geoPoint":94,"contacts":45},"Oakland","94609",{"type":61,"coordinates":91},[92,93],-122.2708,37.80437,{"lat":93,"lon":92},{"facility":45,"status":45,"city":96,"state":56,"zip":97,"country":58,"countryCode":59,"cosmosGeoPoint":98,"geoPoint":102,"contacts":45},"Sacramento","95817",{"type":61,"coordinates":99},[100,101],-121.4944,38.58157,{"lat":101,"lon":100},{"facility":45,"status":45,"city":96,"state":56,"zip":104,"country":58,"countryCode":59,"cosmosGeoPoint":105,"geoPoint":107,"contacts":45},"95825",{"type":61,"coordinates":106},[100,101],{"lat":101,"lon":100},{"facility":45,"status":45,"city":109,"state":56,"zip":110,"country":58,"countryCode":59,"cosmosGeoPoint":111,"geoPoint":115,"contacts":45},"San Diego","92103",{"type":61,"coordinates":112},[113,114],-117.16472,32.71571,{"lat":114,"lon":113},{"facility":45,"status":45,"city":117,"state":56,"zip":118,"country":58,"countryCode":59,"cosmosGeoPoint":119,"geoPoint":123,"contacts":45},"San Francisco","94102",{"type":61,"coordinates":120},[121,122],-122.41942,37.77493,{"lat":122,"lon":121},{"facility":45,"status":45,"city":117,"state":56,"zip":125,"country":58,"countryCode":59,"cosmosGeoPoint":126,"geoPoint":128,"contacts":45},"94103",{"type":61,"coordinates":127},[121,122],{"lat":122,"lon":121},{"facility":45,"status":45,"city":117,"state":56,"zip":130,"country":58,"countryCode":59,"cosmosGeoPoint":131,"geoPoint":133,"contacts":45},"94118",{"type":61,"coordinates":132},[121,122],{"lat":122,"lon":121},{"facility":45,"status":45,"city":135,"state":56,"zip":136,"country":58,"countryCode":59,"cosmosGeoPoint":137,"geoPoint":141,"contacts":45},"Torrance","90502",{"type":61,"coordinates":138},[139,140],-118.34063,33.83585,{"lat":140,"lon":139},{"facility":45,"status":45,"city":143,"state":144,"zip":145,"country":58,"countryCode":59,"cosmosGeoPoint":146,"geoPoint":150,"contacts":45},"Aurora","Colorado","80045",{"type":61,"coordinates":147},[148,149],-104.83192,39.72943,{"lat":149,"lon":148},{"facility":45,"status":45,"city":152,"state":144,"zip":153,"country":58,"countryCode":59,"cosmosGeoPoint":154,"geoPoint":158,"contacts":45},"Denver","80209",{"type":61,"coordinates":155},[156,157],-104.9847,39.73915,{"lat":157,"lon":156},{"facility":45,"status":45,"city":160,"state":161,"zip":162,"country":58,"countryCode":59,"cosmosGeoPoint":163,"geoPoint":167,"contacts":45},"New Haven","Connecticut","06510",{"type":61,"coordinates":164},[165,166],-72.92816,41.30815,{"lat":166,"lon":165},{"facility":45,"status":45,"city":169,"state":170,"zip":171,"country":58,"countryCode":59,"cosmosGeoPoint":172,"geoPoint":176,"contacts":45},"Washington D.C.","District of Columbia","20009",{"type":61,"coordinates":173},[174,175],-77.03637,38.89511,{"lat":175,"lon":174},{"facility":45,"status":45,"city":169,"state":170,"zip":178,"country":58,"countryCode":59,"cosmosGeoPoint":179,"geoPoint":181,"contacts":45},"20036",{"type":61,"coordinates":180},[174,175],{"lat":175,"lon":174},{"facility":45,"status":45,"city":183,"state":184,"zip":185,"country":58,"countryCode":59,"cosmosGeoPoint":186,"geoPoint":190,"contacts":45},"Fort Lauderdale","Florida","33308",{"type":61,"coordinates":187},[188,189],-80.14338,26.12231,{"lat":189,"lon":188},{"facility":45,"status":45,"city":183,"state":184,"zip":192,"country":58,"countryCode":59,"cosmosGeoPoint":193,"geoPoint":195,"contacts":45},"33316",{"type":61,"coordinates":194},[188,189],{"lat":189,"lon":188},{"facility":45,"status":45,"city":197,"state":184,"zip":198,"country":58,"countryCode":59,"cosmosGeoPoint":199,"geoPoint":203,"contacts":45},"Ft. Pierce","34982",{"type":61,"coordinates":200},[201,202],-80.32561,27.44671,{"lat":202,"lon":201},{"facility":45,"status":45,"city":205,"state":184,"zip":206,"country":58,"countryCode":59,"cosmosGeoPoint":207,"geoPoint":211,"contacts":45},"Miami","33136",{"type":61,"coordinates":208},[209,210],-80.19366,25.77427,{"lat":210,"lon":209},{"facility":45,"status":45,"city":213,"state":184,"zip":214,"country":58,"countryCode":59,"cosmosGeoPoint":215,"geoPoint":219,"contacts":45},"Orlando","32803",{"type":61,"coordinates":216},[217,218],-81.37924,28.53834,{"lat":218,"lon":217},{"facility":45,"status":45,"city":221,"state":184,"zip":222,"country":58,"countryCode":59,"cosmosGeoPoint":223,"geoPoint":227,"contacts":45},"Pensacola","32504",{"type":61,"coordinates":224},[225,226],-87.21691,30.42131,{"lat":226,"lon":225},{"facility":45,"status":45,"city":229,"state":184,"zip":230,"country":58,"countryCode":59,"cosmosGeoPoint":231,"geoPoint":235,"contacts":45},"West Palm Beach","33407",{"type":61,"coordinates":232},[233,234],-80.05337,26.71534,{"lat":234,"lon":233},{"facility":45,"status":45,"city":237,"state":238,"zip":239,"country":58,"countryCode":59,"cosmosGeoPoint":240,"geoPoint":244,"contacts":45},"Atlanta","Georgia","30308",{"type":61,"coordinates":241},[242,243],-84.38798,33.749,{"lat":243,"lon":242},{"facility":45,"status":45,"city":237,"state":238,"zip":246,"country":58,"countryCode":59,"cosmosGeoPoint":247,"geoPoint":249,"contacts":45},"30309",{"type":61,"coordinates":248},[242,243],{"lat":243,"lon":242},{"facility":45,"status":45,"city":237,"state":238,"zip":251,"country":58,"countryCode":59,"cosmosGeoPoint":252,"geoPoint":254,"contacts":45},"30312",{"type":61,"coordinates":253},[242,243],{"lat":243,"lon":242},{"facility":45,"status":45,"city":256,"state":238,"zip":257,"country":58,"countryCode":59,"cosmosGeoPoint":258,"geoPoint":262,"contacts":45},"Macon","31201",{"type":61,"coordinates":259},[260,261],-83.6324,32.84069,{"lat":261,"lon":260},{"facility":45,"status":45,"city":264,"state":265,"zip":266,"country":58,"countryCode":59,"cosmosGeoPoint":267,"geoPoint":271,"contacts":45},"Chicago","Illinois","60612",{"type":61,"coordinates":268},[269,270],-87.65005,41.85003,{"lat":270,"lon":269},{"facility":45,"status":45,"city":264,"state":265,"zip":273,"country":58,"countryCode":59,"cosmosGeoPoint":274,"geoPoint":276,"contacts":45},"60613",{"type":61,"coordinates":275},[269,270],{"lat":270,"lon":269},{"facility":45,"status":45,"city":278,"state":279,"zip":280,"country":58,"countryCode":59,"cosmosGeoPoint":281,"geoPoint":285,"contacts":45},"New Orleans","Louisiana","70119",{"type":61,"coordinates":282},[283,284],-90.07507,29.95465,{"lat":284,"lon":283},{"facility":45,"status":45,"city":287,"state":288,"zip":289,"country":58,"countryCode":59,"cosmosGeoPoint":290,"geoPoint":294,"contacts":45},"Boston","Massachusetts","02215",{"type":61,"coordinates":291},[292,293],-71.05977,42.35843,{"lat":293,"lon":292},{"facility":45,"status":45,"city":296,"state":288,"zip":297,"country":58,"countryCode":59,"cosmosGeoPoint":298,"geoPoint":302,"contacts":45},"Springfield","01105",{"type":61,"coordinates":299},[300,301],-72.58981,42.10148,{"lat":301,"lon":300},{"facility":45,"status":45,"city":304,"state":305,"zip":306,"country":58,"countryCode":59,"cosmosGeoPoint":307,"geoPoint":311,"contacts":45},"Berkley","Michigan","48072",{"type":61,"coordinates":308},[309,310],-83.18354,42.50309,{"lat":310,"lon":309},{"facility":45,"status":45,"city":313,"state":305,"zip":314,"country":58,"countryCode":59,"cosmosGeoPoint":315,"geoPoint":319,"contacts":45},"Detroit","48202",{"type":61,"coordinates":316},[317,318],-83.04575,42.33143,{"lat":318,"lon":317},{"facility":45,"status":45,"city":321,"state":322,"zip":323,"country":58,"countryCode":59,"cosmosGeoPoint":324,"geoPoint":328,"contacts":45},"Minneapolis","Minnesota","55415",{"type":61,"coordinates":325},[326,327],-93.26384,44.97997,{"lat":327,"lon":326},{"facility":45,"status":45,"city":330,"state":331,"zip":332,"country":58,"countryCode":59,"cosmosGeoPoint":333,"geoPoint":337,"contacts":45},"Las Vegas","Nevada","89104",{"type":61,"coordinates":334},[335,336],-115.13722,36.17497,{"lat":336,"lon":335},{"facility":45,"status":45,"city":339,"state":340,"zip":341,"country":58,"countryCode":59,"cosmosGeoPoint":342,"geoPoint":346,"contacts":45},"Somers Point","New Jersey","08244",{"type":61,"coordinates":343},[344,345],-74.5946,39.31762,{"lat":345,"lon":344},{"facility":45,"status":45,"city":348,"state":349,"zip":350,"country":58,"countryCode":59,"cosmosGeoPoint":351,"geoPoint":355,"contacts":45},"Santa Fe","New Mexico","87505",{"type":61,"coordinates":352},[353,354],-105.9378,35.68698,{"lat":354,"lon":353},{"facility":45,"status":45,"city":357,"state":357,"zip":358,"country":58,"countryCode":59,"cosmosGeoPoint":359,"geoPoint":363,"contacts":45},"New York","10029",{"type":61,"coordinates":360},[361,362],-74.00597,40.71427,{"lat":362,"lon":361},{"facility":45,"status":45,"city":357,"state":357,"zip":365,"country":58,"countryCode":59,"cosmosGeoPoint":366,"geoPoint":368,"contacts":45},"10032",{"type":61,"coordinates":367},[361,362],{"lat":362,"lon":361},{"facility":45,"status":45,"city":357,"state":357,"zip":370,"country":58,"countryCode":59,"cosmosGeoPoint":371,"geoPoint":373,"contacts":45},"10037",{"type":61,"coordinates":372},[361,362],{"lat":362,"lon":361},{"facility":45,"status":45,"city":375,"state":357,"zip":376,"country":58,"countryCode":59,"cosmosGeoPoint":377,"geoPoint":381,"contacts":45},"The Bronx","10467",{"type":61,"coordinates":378},[379,380],-73.86641,40.84985,{"lat":380,"lon":379},{"facility":45,"status":45,"city":383,"state":384,"zip":385,"country":58,"countryCode":59,"cosmosGeoPoint":386,"geoPoint":390,"contacts":45},"Chapel Hill","North Carolina","27599-7215",{"type":61,"coordinates":387},[388,389],-79.05584,35.9132,{"lat":389,"lon":388},{"facility":45,"status":45,"city":392,"state":384,"zip":393,"country":58,"countryCode":59,"cosmosGeoPoint":394,"geoPoint":398,"contacts":45},"Huntersville","28078",{"type":61,"coordinates":395},[396,397],-80.84285,35.41069,{"lat":397,"lon":396},{"facility":45,"status":45,"city":400,"state":401,"zip":402,"country":58,"countryCode":59,"cosmosGeoPoint":403,"geoPoint":407,"contacts":45},"Cleveland","Ohio","44109",{"type":61,"coordinates":404},[405,406],-81.69541,41.4995,{"lat":406,"lon":405},{"facility":45,"status":45,"city":409,"state":410,"zip":411,"country":58,"countryCode":59,"cosmosGeoPoint":412,"geoPoint":416,"contacts":45},"Philadelphia","Pennsylvania","19107",{"type":61,"coordinates":413},[414,415],-75.16362,39.95238,{"lat":415,"lon":414},{"facility":45,"status":45,"city":418,"state":419,"zip":420,"country":58,"countryCode":59,"cosmosGeoPoint":421,"geoPoint":425,"contacts":45},"Austin","Texas","78705",{"type":61,"coordinates":422},[423,424],-97.74306,30.26715,{"lat":424,"lon":423},{"facility":45,"status":45,"city":427,"state":419,"zip":428,"country":58,"countryCode":59,"cosmosGeoPoint":429,"geoPoint":433,"contacts":45},"Dallas","75208",{"type":61,"coordinates":430},[431,432],-96.80667,32.78306,{"lat":432,"lon":431},{"facility":45,"status":45,"city":427,"state":419,"zip":435,"country":58,"countryCode":59,"cosmosGeoPoint":436,"geoPoint":438,"contacts":45},"75246",{"type":61,"coordinates":437},[431,432],{"lat":432,"lon":431},{"facility":45,"status":45,"city":440,"state":419,"zip":441,"country":58,"countryCode":59,"cosmosGeoPoint":442,"geoPoint":446,"contacts":45},"Houston","77098",{"type":61,"coordinates":443},[444,445],-95.36327,29.76328,{"lat":445,"lon":444},{"facility":45,"status":45,"city":448,"state":449,"zip":450,"country":58,"countryCode":59,"cosmosGeoPoint":451,"geoPoint":455,"contacts":45},"Seattle","Washington","98101",{"type":61,"coordinates":452},[453,454],-122.33207,47.60621,{"lat":454,"lon":453},{"facility":45,"status":45,"city":448,"state":449,"zip":457,"country":58,"countryCode":59,"cosmosGeoPoint":458,"geoPoint":460,"contacts":45},"98104",{"type":61,"coordinates":459},[453,454],{"lat":454,"lon":453},{"facility":45,"status":45,"city":462,"state":463,"zip":464,"country":58,"countryCode":59,"cosmosGeoPoint":465,"geoPoint":469,"contacts":45},"Milwaukee","Wisconsin","53226",{"type":61,"coordinates":466},[467,468],-87.90647,43.0389,{"lat":468,"lon":467},{"facility":45,"status":45,"city":471,"state":45,"zip":472,"country":473,"countryCode":474,"cosmosGeoPoint":475,"geoPoint":479,"contacts":45},"Graz","8051","Austria","AT",{"type":61,"coordinates":476},[477,478],15.44197,47.06733,{"lat":478,"lon":477},{"facility":45,"status":45,"city":481,"state":45,"zip":482,"country":473,"countryCode":474,"cosmosGeoPoint":483,"geoPoint":487,"contacts":45},"Vienna","1090",{"type":61,"coordinates":484},[485,486],16.37208,48.20849,{"lat":486,"lon":485},{"facility":45,"status":45,"city":489,"state":490,"zip":491,"country":492,"countryCode":493,"cosmosGeoPoint":494,"geoPoint":498,"contacts":45},"Vancouver","British Columbia","V6Z 2T1","Canada","CA",{"type":61,"coordinates":495},[496,497],-123.11934,49.24966,{"lat":497,"lon":496},{"facility":45,"status":45,"city":500,"state":501,"zip":502,"country":492,"countryCode":493,"cosmosGeoPoint":503,"geoPoint":507,"contacts":45},"Toronto","Ontario","M5G 1K2",{"type":61,"coordinates":504},[505,506],-79.39864,43.70643,{"lat":506,"lon":505},{"facility":45,"status":45,"city":509,"state":510,"zip":511,"country":492,"countryCode":493,"cosmosGeoPoint":512,"geoPoint":516,"contacts":45},"Montreal","Quebec","H2l 4P9",{"type":61,"coordinates":513},[514,515],-73.58781,45.50884,{"lat":515,"lon":514},{"facility":45,"status":45,"city":509,"state":510,"zip":518,"country":492,"countryCode":493,"cosmosGeoPoint":519,"geoPoint":521,"contacts":45},"H2L5B1",{"type":61,"coordinates":520},[514,515],{"lat":515,"lon":514},{"facility":45,"status":45,"city":509,"state":510,"zip":523,"country":492,"countryCode":493,"cosmosGeoPoint":524,"geoPoint":526,"contacts":45},"H2W 1T8",{"type":61,"coordinates":525},[514,515],{"lat":515,"lon":514},{"facility":45,"status":45,"city":528,"state":529,"zip":530,"country":531,"countryCode":532,"cosmosGeoPoint":533,"geoPoint":537,"contacts":45},"Hvidovre","Capital Region","2650","Denmark","DK",{"type":61,"coordinates":534},[535,536],12.47708,55.64297,{"lat":536,"lon":535},{"facility":45,"status":45,"city":539,"state":540,"zip":541,"country":531,"countryCode":532,"cosmosGeoPoint":542,"geoPoint":546,"contacts":45},"Aarhus N","Central Jutland","8200",{"type":61,"coordinates":543},[544,545],10.17317,56.20367,{"lat":545,"lon":544},{"facility":45,"status":45,"city":548,"state":549,"zip":550,"country":531,"countryCode":532,"cosmosGeoPoint":551,"geoPoint":555,"contacts":45},"Copenhagen","RegionH","2100",{"type":61,"coordinates":552},[553,554],12.56553,55.67594,{"lat":554,"lon":553},{"facility":45,"status":45,"city":557,"state":45,"zip":558,"country":531,"countryCode":532,"cosmosGeoPoint":559,"geoPoint":563,"contacts":45},"Odense","5000",{"type":61,"coordinates":560},[561,562],10.38831,55.39594,{"lat":562,"lon":561},{"facility":45,"status":45,"city":565,"state":566,"zip":567,"country":568,"countryCode":569,"cosmosGeoPoint":570,"geoPoint":574,"contacts":45},"Nice","Alpe Maritimes","6202","France","FR",{"type":61,"coordinates":571},[572,573],7.26608,43.70313,{"lat":573,"lon":572},{"facility":45,"status":45,"city":576,"state":577,"zip":578,"country":568,"countryCode":569,"cosmosGeoPoint":579,"geoPoint":583,"contacts":45},"Marseille","Provence","13006",{"type":61,"coordinates":580},[581,582],5.38107,43.29695,{"lat":582,"lon":581},{"facility":45,"status":45,"city":585,"state":577,"zip":586,"country":568,"countryCode":569,"cosmosGeoPoint":587,"geoPoint":591,"contacts":45},"Paris","75020",{"type":61,"coordinates":588},[589,590],2.3488,48.85341,{"lat":590,"lon":589},{"facility":45,"status":45,"city":585,"state":45,"zip":593,"country":568,"countryCode":569,"cosmosGeoPoint":594,"geoPoint":596,"contacts":45},"75475",{"type":61,"coordinates":595},[589,590],{"lat":590,"lon":589},{"facility":45,"status":45,"city":598,"state":599,"zip":600,"country":601,"countryCode":602,"cosmosGeoPoint":603,"geoPoint":607,"contacts":45},"Munich","Bavaria","81675","Germany","DE",{"type":61,"coordinates":604},[605,606],11.57549,48.13743,{"lat":606,"lon":605},{"facility":45,"status":45,"city":609,"state":45,"zip":610,"country":601,"countryCode":602,"cosmosGeoPoint":611,"geoPoint":615,"contacts":45},"Berlin","10439",{"type":61,"coordinates":612},[613,614],13.41053,52.52437,{"lat":614,"lon":613},{"facility":45,"status":45,"city":609,"state":45,"zip":617,"country":601,"countryCode":602,"cosmosGeoPoint":618,"geoPoint":620,"contacts":45},"10777",{"type":61,"coordinates":619},[613,614],{"lat":614,"lon":613},{"facility":45,"status":45,"city":622,"state":45,"zip":623,"country":601,"countryCode":602,"cosmosGeoPoint":624,"geoPoint":628,"contacts":45},"Frankfurt","60596",{"type":61,"coordinates":625},[626,627],10.53333,49.68333,{"lat":627,"lon":626},{"facility":45,"status":45,"city":630,"state":630,"zip":631,"country":632,"countryCode":633,"cosmosGeoPoint":634,"geoPoint":638,"contacts":45},"Dublin","D07 A8NN","Ireland","IE",{"type":61,"coordinates":635},[636,637],-6.24889,53.33306,{"lat":637,"lon":636},{"facility":45,"status":45,"city":630,"state":45,"zip":640,"country":632,"countryCode":633,"cosmosGeoPoint":641,"geoPoint":643,"contacts":45},"8",{"type":61,"coordinates":642},[636,637],{"lat":637,"lon":636},{"facility":45,"status":45,"city":645,"state":45,"zip":646,"country":647,"countryCode":648,"cosmosGeoPoint":649,"geoPoint":653,"contacts":45},"Milan","20127","Italy","IT",{"type":61,"coordinates":650},[651,652],9.18951,45.46427,{"lat":652,"lon":651},{"facility":45,"status":45,"city":655,"state":45,"zip":656,"country":647,"countryCode":648,"cosmosGeoPoint":657,"geoPoint":661,"contacts":45},"Roma","00149",{"type":61,"coordinates":658},[659,660],11.10642,44.99364,{"lat":660,"lon":659},{"facility":45,"status":45,"city":663,"state":45,"zip":45,"country":664,"countryCode":665,"cosmosGeoPoint":666,"geoPoint":670,"contacts":45},"Amsterdam","Netherlands","NL",{"type":61,"coordinates":667},[668,669],4.88969,52.37403,{"lat":669,"lon":668},{"facility":45,"status":45,"city":672,"state":673,"zip":674,"country":675,"countryCode":676,"cosmosGeoPoint":677,"geoPoint":681,"contacts":45},"Badalona","Barcelona","08907","Spain","ES",{"type":61,"coordinates":678},[679,680],2.24741,41.45004,{"lat":680,"lon":679},{"facility":45,"status":45,"city":673,"state":45,"zip":683,"country":675,"countryCode":676,"cosmosGeoPoint":684,"geoPoint":688,"contacts":45},"08015",{"type":61,"coordinates":685},[686,687],2.15899,41.38879,{"lat":687,"lon":686},{"facility":45,"status":45,"city":690,"state":45,"zip":691,"country":675,"countryCode":676,"cosmosGeoPoint":692,"geoPoint":696,"contacts":45},"Madrid","28010",{"type":61,"coordinates":693},[694,695],-3.70256,40.4165,{"lat":695,"lon":694},{"facility":45,"status":45,"city":698,"state":45,"zip":699,"country":675,"countryCode":676,"cosmosGeoPoint":700,"geoPoint":704,"contacts":45},"Vigo","36312",{"type":61,"coordinates":701},[702,703],-8.72264,42.23282,{"lat":703,"lon":702},{"facility":45,"status":45,"city":706,"state":707,"zip":708,"country":709,"countryCode":710,"cosmosGeoPoint":711,"geoPoint":715,"contacts":45},"Soho","London","W1D 6AQ","United Kingdom","UK",{"type":61,"coordinates":712},[713,714],-0.13535,51.5144,{"lat":714,"lon":713},{"facility":45,"status":45,"city":717,"state":707,"zip":718,"country":709,"countryCode":710,"cosmosGeoPoint":719,"geoPoint":723,"contacts":45},"Whitechapel","E1 1BB",{"type":61,"coordinates":720},[721,722],-0.06583,51.51382,{"lat":722,"lon":721},{"facility":45,"status":45,"city":725,"state":726,"zip":727,"country":709,"countryCode":710,"cosmosGeoPoint":728,"geoPoint":732,"contacts":45},"Edinburgh","Scotland","EH3 9HA",{"type":61,"coordinates":729},[730,731],-3.19648,55.95206,{"lat":731,"lon":730},{"facility":45,"status":45,"city":734,"state":735,"zip":736,"country":709,"countryCode":710,"cosmosGeoPoint":737,"geoPoint":741,"contacts":45},"Brighton","Sussex","BN2 1ES",{"type":61,"coordinates":738},[739,740],-0.13947,50.82838,{"lat":740,"lon":739},{"facility":45,"status":45,"city":743,"state":45,"zip":744,"country":709,"countryCode":710,"cosmosGeoPoint":745,"geoPoint":749,"contacts":45},"Birmingham","B9 5SS",{"type":61,"coordinates":746},[747,748],-1.89983,52.48142,{"lat":748,"lon":747},{"facility":45,"status":45,"city":707,"state":45,"zip":751,"country":709,"countryCode":710,"cosmosGeoPoint":752,"geoPoint":756,"contacts":45},"E9 6SR",{"type":61,"coordinates":753},[754,755],-0.12574,51.50853,{"lat":755,"lon":754},{"facility":45,"status":45,"city":707,"state":45,"zip":758,"country":709,"countryCode":710,"cosmosGeoPoint":759,"geoPoint":761,"contacts":45},"SE18 4QH",{"type":61,"coordinates":760},[754,755],{"lat":755,"lon":754},{"facility":45,"status":45,"city":707,"state":45,"zip":763,"country":709,"countryCode":710,"cosmosGeoPoint":764,"geoPoint":766,"contacts":45},"SE5 9RJ",{"type":61,"coordinates":765},[754,755],{"lat":755,"lon":754},{"facility":45,"status":45,"city":707,"state":45,"zip":768,"country":709,"countryCode":710,"cosmosGeoPoint":769,"geoPoint":771,"contacts":45},"W2 1NY",{"type":61,"coordinates":770},[754,755],{"lat":755,"lon":754},{"facility":45,"status":45,"city":707,"state":45,"zip":773,"country":709,"countryCode":710,"cosmosGeoPoint":774,"geoPoint":776,"contacts":45},"WC1E 6JB",{"type":61,"coordinates":775},[754,755],{"lat":755,"lon":754},{"facility":45,"status":45,"city":778,"state":45,"zip":779,"country":709,"countryCode":710,"cosmosGeoPoint":780,"geoPoint":784,"contacts":45},"Manchester","M13 0FH",{"type":61,"coordinates":781},[782,783],-2.23743,53.48095,{"lat":783,"lon":782},{"type":786,"investigatorFullName":45,"investigatorTitle":45,"investigatorAffiliation":45,"oldNameTitle":45,"oldOrganization":45},"SPONSOR","100273658","phase-3-study-to-evaluate-the-safety-and-efficacy-of-emtricitabine-and-tenofovir-alafenamide-ftaf-fixed-dose-combination-once-daily-for-pre-exposure-prophylaxis-in-men-and-transgender-women-who-have-sex-with-men-and-are-at-risk-of-hiv-1-infection-100273658",true,"NCT02842086","Study to Evaluate the Safety and Efficacy of Emtricitabine and Tenofovir Alafenamide (F\u002FTAF) Fixed-Dose Combination Once Daily for Pre-Exposure Prophylaxis in Men and Transgender Women Who Have Sex With Men and Are At Risk of HIV-1 Infection","A Phase 3, Randomized, Double-blind Study to Evaluate the Safety and Efficacy of Emtricitabine and Tenofovir Alafenamide (F\u002FTAF) Fixed-Dose Combination Once Daily for Pre-Exposure Prophylaxis in Men and Transgender Women Who Have Sex With Men and Are At Risk of HIV-1 Infection","DISCOVER","Key Inclusion Criteria:\n\n* Must be at high risk of sexual acquisition of HIV\n* HIV-1 negative status\n* MSM and TGW (male at birth) who have at least one of the following:\n\n  * condomless anal intercourse with at least two unique male partners in the past 12 weeks (partners must be either HIV-infected or of unknown HIV status)\n  * documented history of syphilis in the past 24 weeks\n  * documented history of rectal gonorrhea or chlamydia in the past 24 weeks\n* Adequate renal function: estimated glomerular filtration rate ≥ 60 mL\u002Fmin according to the Cockcroft-Gault formula\n* Adequate liver and hematologic function:\n\n  * Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 2.5 × upper limit of normal (ULN) and total bilirubin ≤ 1.5 mg\u002FdL, or normal direct bilirubin\n  * Absolute neutrophil count ≥ 1000\u002Fmm\\^3; platelets ≥ 75,000\u002Fmm\\^3; hemoglobin ≥ 10 g\u002FdL\n\nKey Exclusion Criteria\n\n* Grade 3 or Grade 4 proteinuria or glycosuria that is unexplained or not clinically manageable.\n\nNOTE: Other protocol defined Inclusion\u002F Exclusion criteria may apply.","ALL","18 Years",{"count":798,"type":799},5399,"ACTUAL","INTERVENTIONAL",[802],"PHASE3","The primary objective of this study is to assess the rates of HIV-1 infection in Men (MSM) and transgender women (TGW) who have sex with men and who are administered daily emtricitabine\u002Ftenofovir alafenamide (F\u002FTAF) or emtricitabine\u002Ftenofovir disoproxil fumarate (F\u002FTDF) with a minimum follow-up of 48 weeks and at least 50% of participants have 96 weeks of follow-up after randomization.",[805],"Pre-Exposure Prophylaxis of HIV-1 Infection","ACTIVE_NOT_RECRUITING","2026-04-14",{"date":809,"type":799},"2026-05-05",{"date":811,"type":799},"2016-09-02",{"date":813,"type":814},"2026-07","ESTIMATED",{"name":5,"class":6},93]