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HIV-1 RNA level according to the local assay being used if the limit of detection is ≥ 50 copies\u002FmL). Prior changes in antiretroviral regimen are only allowed due to tolerability issues or for regimen simplification. Unconfirmed virologic elevations of ≥ 50 copies\u002FmL (transient detectable viremia, or \"blip\") prior to screening are acceptable. (If the lower limit of detection of the local HIV-1 RNA assay is \\\u003C 50 copies\u002FmL \\[e.g., \\\u003C 20 copies\u002FmL\\], the plasma HIV-1 RNA level cannot exceed 50 copies\u002FmL on two consecutive HIV-1 RNA tests)\n* Have no documented or suspected resistance to FTC, tenofovir, ABC or 3TC, including but not limited to the reverse transcriptase resistance mutations K65R and M184V\u002FI\n* No previous use of any approved or experimental integrase strand transfer inhibitor (INSTI)\n\nKey Exclusion Criteria:\n\n* An opportunistic illness indicative of stage 3 HIV diagnosed within the 30 days prior to screening\n* Individuals experiencing decompensated cirrhosis (eg, ascites, encephalopathy, or variceal bleeding)\n* Have been treated with immunosuppressant therapies or chemotherapeutic agents within 3 months of study screening, or expected to receive these agents or systemic steroids during the study (eg, corticosteroids, immunoglobulins, and other immune- or cytokine based therapies)\n* Current alcohol or substance use judged by the Investigator to potentially interfere with subject study compliance\n* A history of or ongoing malignancy (including untreated carcinoma in-situ) other than cutaneous Kaposi's sarcoma (KS), basal cell carcinoma, or resected, non-invasive cutaneous squamous carcinoma. 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