[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100191498":3},{"organization":4,"armGroups":7,"interventions":30,"overallOfficials":60,"centralContacts":36,"locations":64,"responsibleParty":766,"collaborators":768,"id":771,"slug":772,"hasResults":773,"nctId":774,"briefTitle":775,"officialTitle":776,"acronym":36,"eligibilityCriteria":777,"healthyVolunteers":778,"sex":779,"minAge":780,"maxAge":36,"enrollmentInfo":781,"targetDuration":36,"studyType":784,"phases":785,"briefSummary":787,"conditions":788,"keywords":36,"overallStatus":790,"whyStopped":36,"lastUpdateSubmitDate":791,"lastUpdatePostDateStruct":792,"startDateStruct":794,"completionDateStruct":796,"leadSponsor":798,"locationsCount":799},{"fullName":5,"class":6},"Sanofi","INDUSTRY",[8,19,23],{"label":9,"type":10,"description":11,"interventionNames":12},"Sarilumab 150 mg q2w","EXPERIMENTAL","Sarilumab 150 mg subcutaneous (SC) injection once every 2 weeks (q2w) and placebo intravenous (IV) infusion once every 4 weeks (q4w) was added to one or a combination of the nonbiologic disease modifying antirheumatic drug (DMARD), hydroxychloroquine, methotrexate, sulfasalazine and\u002For leflunomide for 24 weeks, except for the simultaneous use of leflunomide and methotrexate.",[13,14,15,16,17,18],"Drug: sarilumab SAR153191 (REGN88)","Drug: hydroxychloroquine","Drug: methotrexate","Drug: sulfasalazine","Drug: leflunomide","Drug: intravenous placebo",{"label":20,"type":10,"description":21,"interventionNames":22},"Sarilumab 200 mg q2w","Sarilumab 200 mg SC injection q2w and placebo IV infusion q4w was added to one or a combination of the nonbiologic DMARD, hydroxychloroquine, methotrexate, sulfasalazine and\u002For leflunomide for 24 weeks, except for the simultaneous use of leflunomide and methotrexate.",[13,14,15,16,17,18],{"label":24,"type":25,"description":26,"interventionNames":27},"Tocilizumab q4w","ACTIVE_COMPARATOR","Tocilizumab 4 mg\u002Fkg or 8 mg\u002Fkg IV infusion q4w and placebo SC injection q2w was added to one or a combination of the nonbiologic DMARD, hydroxychloroquine, methotrexate, sulfasalazine and\u002For leflunomide for 24 weeks, except for the simultaneous use of leflunomide and methotrexate.",[28,14,15,16,17,29],"Drug: tocilizumab","Drug: subcutaneous placebo",[31,37,41,45,48,51,54,57],{"type":32,"name":33,"description":34,"armGroupLabels":35,"otherNames":36},"DRUG","sarilumab SAR153191 (REGN88)","Pharmaceutical form: solution Route of administration: subcutaneous",[9,20],null,{"type":32,"name":38,"description":39,"armGroupLabels":40,"otherNames":36},"tocilizumab","Pharmaceutical form: solution Route of administration: intravenous",[24],{"type":32,"name":42,"description":43,"armGroupLabels":44,"otherNames":36},"hydroxychloroquine","Dispensed according to local practice.",[9,20,24],{"type":32,"name":46,"description":43,"armGroupLabels":47,"otherNames":36},"methotrexate",[9,20,24],{"type":32,"name":49,"description":43,"armGroupLabels":50,"otherNames":36},"sulfasalazine",[9,20,24],{"type":32,"name":52,"description":43,"armGroupLabels":53,"otherNames":36},"leflunomide",[9,20,24],{"type":32,"name":55,"description":34,"armGroupLabels":56,"otherNames":36},"subcutaneous placebo",[24],{"type":32,"name":58,"description":39,"armGroupLabels":59,"otherNames":36},"intravenous placebo",[9,20],[61],{"name":62,"affiliation":5,"role":63},"Clinical Sciences & Operations","STUDY_DIRECTOR",[65,78,88,98,107,116,125,135,145,155,165,175,184,190,199,205,214,223,231,240,245,256,267,276,286,295,301,312,318,329,338,349,355,364,373,382,391,402,411,422,431,442,451,460,469,478,489,498,509,518,529,538,547,556,562,573,582,588,594,599,608,619,628,634,640,646,652,661,672,681,690,701,710,721,730,739,748,757],{"facility":66,"status":36,"city":67,"state":68,"zip":69,"country":70,"countryCode":71,"cosmosGeoPoint":72,"geoPoint":77,"contacts":36},"Investigational Site Number 840152","Huntsville","Alabama","35801","United States","US",{"type":73,"coordinates":74},"Point",[75,76],-86.58594,34.7304,{"lat":76,"lon":75},{"facility":79,"status":36,"city":80,"state":81,"zip":82,"country":70,"countryCode":71,"cosmosGeoPoint":83,"geoPoint":87,"contacts":36},"Investigational Site Number 840151","Colorado Springs","Colorado","80903",{"type":73,"coordinates":84},[85,86],-104.82136,38.83388,{"lat":86,"lon":85},{"facility":89,"status":36,"city":90,"state":91,"zip":92,"country":70,"countryCode":71,"cosmosGeoPoint":93,"geoPoint":97,"contacts":36},"Investigational Site Number 840153","Aventura","Florida","33180",{"type":73,"coordinates":94},[95,96],-80.13921,25.95648,{"lat":96,"lon":95},{"facility":99,"status":36,"city":100,"state":91,"zip":101,"country":70,"countryCode":71,"cosmosGeoPoint":102,"geoPoint":106,"contacts":36},"Investigational Site Number 840033","Fort Lauderdale","33334",{"type":73,"coordinates":103},[104,105],-80.14338,26.12231,{"lat":105,"lon":104},{"facility":108,"status":36,"city":109,"state":91,"zip":110,"country":70,"countryCode":71,"cosmosGeoPoint":111,"geoPoint":115,"contacts":36},"Investigational Site Number 840048","Miami","33155",{"type":73,"coordinates":112},[113,114],-80.19366,25.77427,{"lat":114,"lon":113},{"facility":117,"status":36,"city":118,"state":91,"zip":119,"country":70,"countryCode":71,"cosmosGeoPoint":120,"geoPoint":124,"contacts":36},"Investigational Site Number 840155","Palm Harbor","34684",{"type":73,"coordinates":121},[122,123],-82.76371,28.07807,{"lat":123,"lon":122},{"facility":126,"status":36,"city":127,"state":128,"zip":129,"country":70,"countryCode":71,"cosmosGeoPoint":130,"geoPoint":134,"contacts":36},"Investigational Site Number 840013","Wheaton","Maryland","20902",{"type":73,"coordinates":131},[132,133],-77.05526,39.03983,{"lat":133,"lon":132},{"facility":136,"status":36,"city":137,"state":138,"zip":139,"country":70,"countryCode":71,"cosmosGeoPoint":140,"geoPoint":144,"contacts":36},"Investigational Site Number 840154","Boston","Massachusetts","02115",{"type":73,"coordinates":141},[142,143],-71.05977,42.35843,{"lat":143,"lon":142},{"facility":146,"status":36,"city":147,"state":148,"zip":149,"country":70,"countryCode":71,"cosmosGeoPoint":150,"geoPoint":154,"contacts":36},"Investigational Site Number 840150","Lansing","Michigan","48910",{"type":73,"coordinates":151},[152,153],-84.55553,42.73253,{"lat":153,"lon":152},{"facility":156,"status":36,"city":157,"state":158,"zip":159,"country":70,"countryCode":71,"cosmosGeoPoint":160,"geoPoint":164,"contacts":36},"Investigational Site Number 840062","Reading","Pennsylvania","19611",{"type":73,"coordinates":161},[162,163],-75.92687,40.33565,{"lat":163,"lon":162},{"facility":166,"status":36,"city":167,"state":168,"zip":169,"country":70,"countryCode":71,"cosmosGeoPoint":170,"geoPoint":174,"contacts":36},"Investigational Site Number 840038","Austin","Texas","78705",{"type":73,"coordinates":171},[172,173],-97.74306,30.26715,{"lat":173,"lon":172},{"facility":176,"status":36,"city":177,"state":168,"zip":178,"country":70,"countryCode":71,"cosmosGeoPoint":179,"geoPoint":183,"contacts":36},"Investigational Site Number 840022","Dallas","75235",{"type":73,"coordinates":180},[181,182],-96.80667,32.78306,{"lat":182,"lon":181},{"facility":185,"status":36,"city":177,"state":168,"zip":186,"country":70,"countryCode":71,"cosmosGeoPoint":187,"geoPoint":189,"contacts":36},"Investigational Site Number 840156","75246",{"type":73,"coordinates":188},[181,182],{"lat":182,"lon":181},{"facility":191,"status":36,"city":192,"state":168,"zip":193,"country":70,"countryCode":71,"cosmosGeoPoint":194,"geoPoint":198,"contacts":36},"Investigational Site Number 840074","Mesquite","75150",{"type":73,"coordinates":195},[196,197],-96.59916,32.7668,{"lat":197,"lon":196},{"facility":200,"status":36,"city":201,"state":36,"zip":202,"country":203,"countryCode":204,"cosmosGeoPoint":36,"geoPoint":36,"contacts":36},"Investigational Site Number 032006","Caba","C1015ABO","Argentina","AR",{"facility":206,"status":36,"city":207,"state":36,"zip":208,"country":203,"countryCode":204,"cosmosGeoPoint":209,"geoPoint":213,"contacts":36},"Investigational Site Number 032010","Ramos Mejía","B1704ETD",{"type":73,"coordinates":210},[211,212],-58.55318,-34.6551,{"lat":212,"lon":211},{"facility":215,"status":36,"city":216,"state":36,"zip":217,"country":203,"countryCode":204,"cosmosGeoPoint":218,"geoPoint":222,"contacts":36},"Investigational Site Number 032013","Rosario","S200PBJ",{"type":73,"coordinates":219},[220,221],-60.63932,-32.94682,{"lat":221,"lon":220},{"facility":224,"status":36,"city":225,"state":36,"zip":36,"country":203,"countryCode":204,"cosmosGeoPoint":226,"geoPoint":230,"contacts":36},"Investigational Site Number 032015","San Fernando",{"type":73,"coordinates":227},[228,229],-58.56279,-34.44104,{"lat":229,"lon":228},{"facility":232,"status":36,"city":233,"state":36,"zip":234,"country":203,"countryCode":204,"cosmosGeoPoint":235,"geoPoint":239,"contacts":36},"Investigational Site Number 032004","San Miguel de Tucumán","4000",{"type":73,"coordinates":236},[237,238],-65.21051,-26.81601,{"lat":238,"lon":237},{"facility":241,"status":36,"city":233,"state":36,"zip":234,"country":203,"countryCode":204,"cosmosGeoPoint":242,"geoPoint":244,"contacts":36},"Investigational Site Number 032005",{"type":73,"coordinates":243},[237,238],{"lat":238,"lon":237},{"facility":246,"status":36,"city":247,"state":36,"zip":248,"country":249,"countryCode":250,"cosmosGeoPoint":251,"geoPoint":255,"contacts":36},"Investigational Site Number 056010","Leuven","3000","Belgium","BE",{"type":73,"coordinates":252},[253,254],4.70093,50.87959,{"lat":254,"lon":253},{"facility":257,"status":36,"city":258,"state":36,"zip":259,"country":260,"countryCode":261,"cosmosGeoPoint":262,"geoPoint":266,"contacts":36},"Investigational Site Number 076001","Curitiba","80060-240","Brazil","BR",{"type":73,"coordinates":263},[264,265],-49.27306,-25.42778,{"lat":265,"lon":264},{"facility":268,"status":36,"city":269,"state":36,"zip":270,"country":260,"countryCode":261,"cosmosGeoPoint":271,"geoPoint":275,"contacts":36},"Investigational Site Number 076030","São José do Rio Preto","15090-000",{"type":73,"coordinates":272},[273,274],-49.37944,-20.81972,{"lat":274,"lon":273},{"facility":277,"status":36,"city":278,"state":36,"zip":279,"country":280,"countryCode":36,"cosmosGeoPoint":281,"geoPoint":285,"contacts":36},"Investigational Site Number 203009","Liberec","46063","Czechia",{"type":73,"coordinates":282},[283,284],15.05619,50.76711,{"lat":284,"lon":283},{"facility":287,"status":36,"city":288,"state":36,"zip":289,"country":280,"countryCode":36,"cosmosGeoPoint":290,"geoPoint":294,"contacts":36},"Investigational Site Number 203011","Prague","12850",{"type":73,"coordinates":291},[292,293],14.42076,50.08804,{"lat":293,"lon":292},{"facility":296,"status":36,"city":288,"state":36,"zip":297,"country":280,"countryCode":36,"cosmosGeoPoint":298,"geoPoint":300,"contacts":36},"Investigational Site Number 203010","140 00",{"type":73,"coordinates":299},[292,293],{"lat":293,"lon":292},{"facility":302,"status":36,"city":303,"state":36,"zip":304,"country":305,"countryCode":306,"cosmosGeoPoint":307,"geoPoint":311,"contacts":36},"Investigational Site Number 233010","Tallinn","10138","Estonia","EE",{"type":73,"coordinates":308},[309,310],24.75353,59.43696,{"lat":310,"lon":309},{"facility":313,"status":36,"city":303,"state":36,"zip":314,"country":305,"countryCode":306,"cosmosGeoPoint":315,"geoPoint":317,"contacts":36},"Investigational Site Number 233002","13419",{"type":73,"coordinates":316},[309,310],{"lat":310,"lon":309},{"facility":319,"status":36,"city":320,"state":36,"zip":321,"country":322,"countryCode":323,"cosmosGeoPoint":324,"geoPoint":328,"contacts":36},"Investigational Site Number 246001","Helsinki","00290","Finland","FI",{"type":73,"coordinates":325},[326,327],24.93545,60.16952,{"lat":327,"lon":326},{"facility":330,"status":36,"city":331,"state":36,"zip":332,"country":322,"countryCode":323,"cosmosGeoPoint":333,"geoPoint":337,"contacts":36},"Investigational Site Number 246010","Riihimäki","11120",{"type":73,"coordinates":334},[335,336],24.77726,60.73769,{"lat":336,"lon":335},{"facility":339,"status":36,"city":340,"state":36,"zip":341,"country":342,"countryCode":343,"cosmosGeoPoint":344,"geoPoint":348,"contacts":36},"Investigational Site Number 348014","Budapest","1027","Hungary","HU",{"type":73,"coordinates":345},[346,347],19.04045,47.49835,{"lat":347,"lon":346},{"facility":350,"status":36,"city":340,"state":36,"zip":351,"country":342,"countryCode":343,"cosmosGeoPoint":352,"geoPoint":354,"contacts":36},"Investigational Site Number 348022","1036",{"type":73,"coordinates":353},[346,347],{"lat":347,"lon":346},{"facility":356,"status":36,"city":357,"state":36,"zip":358,"country":342,"countryCode":343,"cosmosGeoPoint":359,"geoPoint":363,"contacts":36},"Investigational Site Number 348021","Esztergom","2500",{"type":73,"coordinates":360},[361,362],18.74148,47.7928,{"lat":362,"lon":361},{"facility":365,"status":36,"city":366,"state":36,"zip":367,"country":342,"countryCode":343,"cosmosGeoPoint":368,"geoPoint":372,"contacts":36},"Investigational Site Number 348016","Kistarcsa","2143",{"type":73,"coordinates":369},[370,371],19.26247,47.54757,{"lat":371,"lon":370},{"facility":374,"status":36,"city":375,"state":36,"zip":376,"country":342,"countryCode":343,"cosmosGeoPoint":377,"geoPoint":381,"contacts":36},"Investigational Site Number 348009","Szolnok","5000",{"type":73,"coordinates":378},[379,380],20.19835,47.18066,{"lat":380,"lon":379},{"facility":383,"status":36,"city":384,"state":36,"zip":385,"country":342,"countryCode":343,"cosmosGeoPoint":386,"geoPoint":390,"contacts":36},"Investigational Site Number 348015","Szombathely","9700",{"type":73,"coordinates":387},[388,389],16.62155,47.23088,{"lat":389,"lon":388},{"facility":392,"status":36,"city":393,"state":36,"zip":394,"country":395,"countryCode":396,"cosmosGeoPoint":397,"geoPoint":401,"contacts":36},"Investigational Site Number 376010","Haifa","31096","Israel","IL",{"type":73,"coordinates":398},[399,400],34.99928,32.81303,{"lat":400,"lon":399},{"facility":403,"status":36,"city":404,"state":36,"zip":405,"country":395,"countryCode":396,"cosmosGeoPoint":406,"geoPoint":410,"contacts":36},"Investigational Site Number 376011","Tel Aviv","64239",{"type":73,"coordinates":407},[408,409],34.78057,32.08088,{"lat":409,"lon":408},{"facility":412,"status":36,"city":413,"state":36,"zip":414,"country":415,"countryCode":416,"cosmosGeoPoint":417,"geoPoint":421,"contacts":36},"Investigational Site Number 380002","Florence","50141","Italy","IT",{"type":73,"coordinates":418},[419,420],11.24626,43.77925,{"lat":420,"lon":419},{"facility":423,"status":36,"city":424,"state":36,"zip":425,"country":415,"countryCode":416,"cosmosGeoPoint":426,"geoPoint":430,"contacts":36},"Investigational Site Number 380005","Genova","16132",{"type":73,"coordinates":427},[428,429],11.87211,45.21604,{"lat":429,"lon":428},{"facility":432,"status":36,"city":433,"state":36,"zip":434,"country":435,"countryCode":436,"cosmosGeoPoint":437,"geoPoint":441,"contacts":36},"Investigational Site Number 484008","Durango","34080","Mexico","MX",{"type":73,"coordinates":438},[439,440],-104.65756,24.02032,{"lat":440,"lon":439},{"facility":443,"status":36,"city":444,"state":36,"zip":445,"country":435,"countryCode":436,"cosmosGeoPoint":446,"geoPoint":450,"contacts":36},"Investigational Site Number 484035","León","37000",{"type":73,"coordinates":447},[448,449],-103.47698,25.60187,{"lat":449,"lon":448},{"facility":452,"status":36,"city":453,"state":36,"zip":454,"country":435,"countryCode":436,"cosmosGeoPoint":455,"geoPoint":459,"contacts":36},"Investigational Site Number 484009","Mérida","97000",{"type":73,"coordinates":456},[457,458],-89.62318,20.967,{"lat":458,"lon":457},{"facility":461,"status":36,"city":462,"state":36,"zip":463,"country":435,"countryCode":436,"cosmosGeoPoint":464,"geoPoint":468,"contacts":36},"Investigational Site Number 484001","México, D.F.","11850",{"type":73,"coordinates":465},[466,467],-108.15213,31.00435,{"lat":467,"lon":466},{"facility":470,"status":36,"city":471,"state":36,"zip":472,"country":435,"countryCode":436,"cosmosGeoPoint":473,"geoPoint":477,"contacts":36},"Investigational Site Number 484036","Zapopan","44280",{"type":73,"coordinates":474},[475,476],-103.38742,20.72111,{"lat":476,"lon":475},{"facility":479,"status":36,"city":480,"state":36,"zip":481,"country":482,"countryCode":483,"cosmosGeoPoint":484,"geoPoint":488,"contacts":36},"Investigational Site Number 528010","Amsterdam","1056 AB","Netherlands","NL",{"type":73,"coordinates":485},[486,487],4.88969,52.37403,{"lat":487,"lon":486},{"facility":490,"status":36,"city":491,"state":36,"zip":492,"country":482,"countryCode":483,"cosmosGeoPoint":493,"geoPoint":497,"contacts":36},"Investigational Site Number 528001","Leiden","2333 ZA",{"type":73,"coordinates":494},[495,496],4.49306,52.15833,{"lat":496,"lon":495},{"facility":499,"status":36,"city":500,"state":36,"zip":501,"country":502,"countryCode":503,"cosmosGeoPoint":504,"geoPoint":508,"contacts":36},"Investigational Site Number 578010","Kristiansand","4604","Norway","NO",{"type":73,"coordinates":505},[506,507],7.9956,58.14671,{"lat":507,"lon":506},{"facility":510,"status":36,"city":511,"state":36,"zip":512,"country":502,"countryCode":503,"cosmosGeoPoint":513,"geoPoint":517,"contacts":36},"Investigational Site Number 578006","Tønsberg","3105",{"type":73,"coordinates":514},[515,516],10.40762,59.26754,{"lat":516,"lon":515},{"facility":519,"status":36,"city":520,"state":36,"zip":521,"country":522,"countryCode":523,"cosmosGeoPoint":524,"geoPoint":528,"contacts":36},"Investigational Site Number 616019","Bydgoszcz","85-168","Poland","PL",{"type":73,"coordinates":525},[526,527],18.00762,53.1235,{"lat":527,"lon":526},{"facility":530,"status":36,"city":531,"state":36,"zip":532,"country":522,"countryCode":523,"cosmosGeoPoint":533,"geoPoint":537,"contacts":36},"Investigational Site Number 616054","Bytom","41-902",{"type":73,"coordinates":534},[535,536],18.93282,50.34802,{"lat":536,"lon":535},{"facility":539,"status":36,"city":540,"state":36,"zip":541,"country":522,"countryCode":523,"cosmosGeoPoint":542,"geoPoint":546,"contacts":36},"Investigational Site Number 616030","Lublin","20-090",{"type":73,"coordinates":543},[544,545],22.57009,51.25058,{"lat":545,"lon":544},{"facility":548,"status":36,"city":549,"state":36,"zip":550,"country":522,"countryCode":523,"cosmosGeoPoint":551,"geoPoint":555,"contacts":36},"Investigational Site Number 616031","Warsaw","01-518",{"type":73,"coordinates":552},[553,554],21.01178,52.22977,{"lat":554,"lon":553},{"facility":557,"status":36,"city":549,"state":36,"zip":558,"country":522,"countryCode":523,"cosmosGeoPoint":559,"geoPoint":561,"contacts":36},"Investigational Site Number 616017","02-653",{"type":73,"coordinates":560},[553,554],{"lat":554,"lon":553},{"facility":563,"status":36,"city":564,"state":36,"zip":565,"country":566,"countryCode":567,"cosmosGeoPoint":568,"geoPoint":572,"contacts":36},"Investigational Site Number 642006","Brăila","810019","Romania","RO",{"type":73,"coordinates":569},[570,571],27.97429,45.27152,{"lat":571,"lon":570},{"facility":574,"status":36,"city":575,"state":36,"zip":576,"country":566,"countryCode":567,"cosmosGeoPoint":577,"geoPoint":581,"contacts":36},"Investigational Site Number 642021","Bucharest","010584",{"type":73,"coordinates":578},[579,580],26.10626,44.43225,{"lat":580,"lon":579},{"facility":583,"status":36,"city":575,"state":36,"zip":584,"country":566,"countryCode":567,"cosmosGeoPoint":585,"geoPoint":587,"contacts":36},"Investigational Site Number 642001","010976",{"type":73,"coordinates":586},[579,580],{"lat":580,"lon":579},{"facility":589,"status":36,"city":575,"state":36,"zip":590,"country":566,"countryCode":567,"cosmosGeoPoint":591,"geoPoint":593,"contacts":36},"Investigational Site Number 642020","020125",{"type":73,"coordinates":592},[579,580],{"lat":580,"lon":579},{"facility":595,"status":36,"city":575,"state":36,"zip":36,"country":566,"countryCode":567,"cosmosGeoPoint":596,"geoPoint":598,"contacts":36},"Investigational Site Number 642010",{"type":73,"coordinates":597},[579,580],{"lat":580,"lon":579},{"facility":600,"status":36,"city":601,"state":36,"zip":602,"country":566,"countryCode":567,"cosmosGeoPoint":603,"geoPoint":607,"contacts":36},"Investigational Site Number 642022","Targoviste","130083",{"type":73,"coordinates":604},[605,606],25.4567,44.92543,{"lat":606,"lon":605},{"facility":609,"status":36,"city":610,"state":36,"zip":611,"country":612,"countryCode":613,"cosmosGeoPoint":614,"geoPoint":618,"contacts":36},"Investigational Site Number 643017","Kemerovo","650066","Russia","RU",{"type":73,"coordinates":615},[616,617],86.10435,55.35417,{"lat":617,"lon":616},{"facility":620,"status":36,"city":621,"state":36,"zip":622,"country":612,"countryCode":613,"cosmosGeoPoint":623,"geoPoint":627,"contacts":36},"Investigational Site Number 643020","Moscow","115404",{"type":73,"coordinates":624},[625,626],37.61781,55.75204,{"lat":626,"lon":625},{"facility":629,"status":36,"city":621,"state":36,"zip":630,"country":612,"countryCode":613,"cosmosGeoPoint":631,"geoPoint":633,"contacts":36},"Investigational Site Number 643001","115522",{"type":73,"coordinates":632},[625,626],{"lat":626,"lon":625},{"facility":635,"status":36,"city":621,"state":36,"zip":636,"country":612,"countryCode":613,"cosmosGeoPoint":637,"geoPoint":639,"contacts":36},"Investigational Site Number 643002","117997",{"type":73,"coordinates":638},[625,626],{"lat":626,"lon":625},{"facility":641,"status":36,"city":621,"state":36,"zip":642,"country":612,"countryCode":613,"cosmosGeoPoint":643,"geoPoint":645,"contacts":36},"Investigational Site Number 643031","121374",{"type":73,"coordinates":644},[625,626],{"lat":626,"lon":625},{"facility":647,"status":36,"city":621,"state":36,"zip":648,"country":612,"countryCode":613,"cosmosGeoPoint":649,"geoPoint":651,"contacts":36},"Investigational Site Number 643030","125284",{"type":73,"coordinates":650},[625,626],{"lat":626,"lon":625},{"facility":653,"status":36,"city":654,"state":36,"zip":655,"country":612,"countryCode":613,"cosmosGeoPoint":656,"geoPoint":660,"contacts":36},"Investigational Site Number 643032","Saint Petersburg","191186",{"type":73,"coordinates":657},[658,659],30.31413,59.93863,{"lat":659,"lon":658},{"facility":662,"status":36,"city":663,"state":36,"zip":664,"country":665,"countryCode":666,"cosmosGeoPoint":667,"geoPoint":671,"contacts":36},"Investigational Site Number 724020","Barcelona","08035","Spain","ES",{"type":73,"coordinates":668},[669,670],2.15899,41.38879,{"lat":670,"lon":669},{"facility":673,"status":36,"city":674,"state":36,"zip":675,"country":665,"countryCode":666,"cosmosGeoPoint":676,"geoPoint":680,"contacts":36},"Investigational Site Number 724021","Santander","39008",{"type":73,"coordinates":677},[678,679],-3.80493,43.46589,{"lat":679,"lon":678},{"facility":682,"status":36,"city":683,"state":36,"zip":684,"country":665,"countryCode":666,"cosmosGeoPoint":685,"geoPoint":689,"contacts":36},"Investigational Site Number 724022","Seville","41010",{"type":73,"coordinates":686},[687,688],-5.97317,37.38283,{"lat":688,"lon":687},{"facility":691,"status":36,"city":692,"state":36,"zip":693,"country":694,"countryCode":695,"cosmosGeoPoint":696,"geoPoint":700,"contacts":36},"Investigational Site Number 752004","Malmö","205 02","Sweden","SE",{"type":73,"coordinates":697},[698,699],13.00073,55.60587,{"lat":699,"lon":698},{"facility":702,"status":36,"city":703,"state":36,"zip":704,"country":694,"countryCode":695,"cosmosGeoPoint":705,"geoPoint":709,"contacts":36},"Investigational Site Number 752002","Uppsala","751 85",{"type":73,"coordinates":706},[707,708],17.63889,59.85882,{"lat":708,"lon":707},{"facility":711,"status":36,"city":712,"state":36,"zip":713,"country":714,"countryCode":715,"cosmosGeoPoint":716,"geoPoint":720,"contacts":36},"Investigational Site Number 826004","Doncaster","DN2 5LT","United Kingdom","UK",{"type":73,"coordinates":717},[718,719],-1.13116,53.52285,{"lat":719,"lon":718},{"facility":722,"status":36,"city":723,"state":36,"zip":724,"country":714,"countryCode":715,"cosmosGeoPoint":725,"geoPoint":729,"contacts":36},"Investigational Site Number 826006","Edinburgh","EH4 2XU",{"type":73,"coordinates":726},[727,728],-3.19648,55.95206,{"lat":728,"lon":727},{"facility":731,"status":36,"city":732,"state":36,"zip":733,"country":714,"countryCode":715,"cosmosGeoPoint":734,"geoPoint":738,"contacts":36},"Investigational Site Number 826001","Leeds","LS7 4SA",{"type":73,"coordinates":735},[736,737],-1.54785,53.79648,{"lat":737,"lon":736},{"facility":740,"status":36,"city":741,"state":36,"zip":742,"country":714,"countryCode":715,"cosmosGeoPoint":743,"geoPoint":747,"contacts":36},"Investigational Site Number 826002","London","E11 1NR",{"type":73,"coordinates":744},[745,746],-0.12574,51.50853,{"lat":746,"lon":745},{"facility":749,"status":36,"city":750,"state":36,"zip":751,"country":714,"countryCode":715,"cosmosGeoPoint":752,"geoPoint":756,"contacts":36},"Investigational Site Number 826005","Southampton","SO16 6YD",{"type":73,"coordinates":753},[754,755],-1.40428,50.90395,{"lat":755,"lon":754},{"facility":758,"status":36,"city":759,"state":36,"zip":760,"country":714,"countryCode":715,"cosmosGeoPoint":761,"geoPoint":765,"contacts":36},"Investigational Site Number 826025","Wigan","WN6 9EP",{"type":73,"coordinates":762},[763,764],-2.63706,53.54296,{"lat":764,"lon":763},{"type":767,"investigatorFullName":36,"investigatorTitle":36,"investigatorAffiliation":36,"oldNameTitle":36,"oldOrganization":36},"SPONSOR",[769],{"name":770,"class":6},"Regeneron Pharmaceuticals","100191498","phase-3-to-evaluate-the-safety-of-sar153191-regn88-and-tocilizumab-added-to-other-ra-drugs-in-patients-with-ra-who-are-not-responding-to-or-intolerant-of-anti-tnf-therapy-saril-ra-ascertain-100191498",true,"NCT01768572","To Evaluate The Safety of SAR153191 (REGN88) and Tocilizumab Added to Other RA Drugs in Patients With RA Who Are Not Responding to or Intolerant of Anti-TNF Therapy (SARIL-RA-ASCERTAIN)","A Randomized, Double-Blind, Double-Dummy Study Assessing The Safety and Tolerability of Sarilumab and Tocilizumab In Patients With Rheumatoid Arthritis Who Are Inadequate Responders to or Intolerant of TNF Antagonists","Inclusion criteria:\n\nDiagnosis of RA was, according to the American College of Rheumatology (ACR)\u002FEuropean League against Rheumatism (EULAR) 2010 Rheumatoid Arthritis Classification Criteria with ≥ 3 months disease duration\n\nACR Class I-III functional status, was based on the 1991 revised criteria. Moderate-to-severely active RA. Anti-TNF therapy failures, was defined as participants with an inadequate clinical response was defined by the investigator, after being treated for at least 3 consecutive months, and\u002For intolerance to at least 1 TNF-antagonist, resulting in or requiring their discontinuation. TNF-antagonists were include, but were not limited to, etanercept, infliximab, adalimumab, golimumab and\u002For certolizumab pegol\n\nContinuous treatment with one or a combination of non-biologic disease modifying antirheumatic drugs (DMARDs) for at least 12 consecutive weeks prior to screening and on a stable dose(s) for at least 6 consecutive weeks prior to screening:\n\n* Methotrexate - 10 to 25 milligram\u002Fweek orally or parenteral (or per local labelling requirements if the dose range differs)\n* Leflunomide - 10 to 20 mg orally daily\n* Sulfasalazine (SSZ) - 1000 to 3000 mg orally daily\n* Hydroxychloroquine (HCQ) - 200 to 400 mg orally daily\n\nExclusion criteria:\n\nParticipants \\\u003C18 years of age. Use of parenteral corticosteroids or intra-articular corticosteroids within 4 weeks prior to screening\n\nUse of oral corticosteroids in a dose higher than prednisone 10 mg or equivalent per day, or a change in dosage within 4 weeks prior to screening\n\nPast history of, or current, autoimmune or inflammatory systemic or localized joint disease(s) other than RA\n\nHistory of juvenile idiopathic arthritis or arthritis onset prior to age 16. Severe systemic RA, including but not limited to vasculitis, pulmonary fibrosis, and\u002For Felty's syndrome\n\nParticipation in any clinical research study that evaluated an investigational drug or therapy within 5 half-lives or 60 days of the Screening Visit, whichever was longer\n\nParticipants with active tuberculosis or latent tuberculosis infection. Prior or current history of interstitial lung disease. Prior treatment with anti-interleukin (IL) -6 or anti-IL-6R therapies, including but not limited to tocilizumab or sarilumab\n\nTreatment with anti-TNF agents, as follows:\n\n* Etanercept: within 28 days prior to randomization\n* Infliximab, adalimumab, golimumab, certolizumab pegol: within 42 days prior to randomization\n\nTreatment with RA-directed biologic agents with non- TNF-α antagonist mechanisms without adequate washout as follows:\n\n* Anakinra: within 28 days prior to randomization\n* Abatacept: within 42 days prior to randomization\n* Rituximab or other cell depleting agent: Within 6 months prior to randomization or until total lymphocyte count and CD 19+ lymphocyte count were normalized, or whichever was longer\n\nPrior treatment with a janus kinase (JAK) inhibitor (eg, tofacitinib). Participants with a history of invasive opportunistic infection. Prior or current history of malignancy, including lymphoproliferative diseases, other than adequately-treated carcinoma in-situ of the cervix, nonmetastatic squamous cell or basal cell carcinoma of the skin, within 5 years prior to the randomization (baseline) visit\n\nPrior or current history of other significant concomitant illness(es) that, according to Investigator's judgement, was adversely affect the participant's participation in the study.\n\nThe above information was not intended to contain all considerations relevant to a participant's potential participation in a clinical trial.",false,"ALL","18 Years",{"count":782,"type":783},202,"ACTUAL","INTERVENTIONAL",[786],"PHASE3","Primary Objective:\n\nTo assess, in the same study, the safety of sarilumab and tocilizumab in participants with rheumatoid arthritis (RA) who were inadequate responders to or intolerant of tumor necrosis factor (TNF) antagonists.",[789],"Rheumatoid Arthritis","COMPLETED","2017-06-23",{"date":793,"type":783},"2017-06-26",{"date":795,"type":36},"2013-03",{"date":797,"type":783},"2014-10",{"name":5,"class":6},78]