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Hospital","138736",{"type":27,"coordinates":142},[129,130],{"lat":130,"lon":129},{"facility":145,"status":7,"city":146,"state":7,"zip":147,"country":104,"countryCode":7,"cosmosGeoPoint":148,"geoPoint":152,"contacts":7},"A-Jou University Hospital","Suwon","443721",{"type":27,"coordinates":149},[150,151],127.00889,37.29111,{"lat":151,"lon":150},{"facility":154,"status":7,"city":155,"state":7,"zip":7,"country":104,"countryCode":7,"cosmosGeoPoint":156,"geoPoint":160,"contacts":7},"Wonju Christian Hospital (Yonsei University Hosp)","Wŏnju",{"type":27,"coordinates":157},[158,159],127.94528,37.35139,{"lat":159,"lon":158},"100068843","phase-3-trial-to-compare-the-efficacy-and-safety-of-a-single-bolus-of-tnk-tpa-tenecteplase-metalyse-with-accelerated-infusion-of-rt-pa-alteplase-actilyse-in-asian-patients-with-acute-myocardial-infarction-100068843",false,"NCT00148460","Trial to Compare the Efficacy and Safety of a Single Bolus of TNK-tPA (Tenecteplase, Metalyse®) With Accelerated Infusion of Rt-PA (Alteplase, Actilyse®) in Asian Patients With Acute Myocardial Infarction","A Randomised, Open-label, Multi-center, Angiographic Trial to Compare the Efficacy and Safety of Single Bolus of Tenecteplase (Metalyse®) With Accelerated Infusion of Alteplase in Asian Patients With Acute Myocardial Infarction","Inclusion Criteria:\n\n1. Age \\>= 18 and \\\u003C= 75 years.\n2. Asian origin.\n3. Ischemic discomfort \\>= 30 minutes in duration.\n4. Onset of acute myocardial infarction (AMI) symptoms within 6 hours prior to randomization.\n5. A twelve lead electrocardiogram (ECG) with one of the following:\n\n   * ST segment elevation \\>= 0.1 mV in two or more limb leads; or\n   * \\>= 0.2 mV in two or more contiguous precordial leads indicative of AMI.\n6. Ability to give informed consent.\n\nExclusion Criteria:\n\n1. Previous coronary artery bypass grafting (CABG) surgery.\n2. Cardiogenic shock (e.g. systolic blood pressure \\[SBP\\] \\\u003C 90 mmHg).\n3. Systolic blood pressure (SBP) \\>= 180 mmHg and\u002For diastolic blood pressure (DBP) \\>= 110 mmHg during current admission on one reliable measurement prior to randomization.\n4. Inability to undergo cardiac catheterization.\n5. Significant bleeding disorder either at present or within the past 6 months.\n6. Major surgery, biopsy of a parenchymal organ, or significant trauma within 3 months.\n7. Any minor head trauma and\u002For any other trauma that occurred after onset of current myocardial infarction.\n8. Use of heparin, GPIIb\u002FIIIa antagonists or other anticoagulants within the last 2 weeks.\n9. Any known history of stroke or transient ischemic attack or central nervous system structural damage (i.e. neoplasm, aneurysm, intracranial surgery).\n10. Prolonged cardiopulmonary resuscitation (\\> 10 minutes) within 2 weeks.\n11. Pregnancy, lactation or parturition within the previous 30 days. Women of childbearing potential must have had a negative pregnancy test and must have used a medically accepted method of birth control (i.e. uterine device, surgical sterilisation, progestogens alone).\n12. Previous treatment with TNK-tPA (tenecteplase).\n13. Inability to follow protocol and comply with follow-up.\n14. Drug abuse within the last year.\n15. Participation in another clinical trial within the previous 30 days.","ALL","18 Years","75 Years",{"count":172,"type":7},270,"INTERVENTIONAL",[175],"PHASE3","The objective of this trial was to compare the efficacy and safety of a single bolus of TNK-tPA (tenecteplase, Metalyse®) compared with rt-PA (alteplase, Actilyse®) in Asian patients.",[178],"Myocardial Infarction","COMPLETED","2013-10-28",{"date":182,"type":183},"2013-10-29","ESTIMATED",{"date":185,"type":7},"2001-03",{"date":187,"type":7},"2006-02",{"name":5,"class":6},18]