[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100338978":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":22,"centralContacts":22,"locations":23,"responsibleParty":71,"collaborators":73,"id":77,"slug":78,"hasResults":79,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":79,"sex":85,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":22,"studyType":91,"phases":92,"briefSummary":94,"conditions":95,"keywords":22,"overallStatus":98,"whyStopped":22,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"Fundacion SEIMC-GESIDA","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Arm 1","EXPERIMENTAL","Naive HIV patients with severe immunosuppression.",[13],"Drug: Genvoya®",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DRUG","Genvoya®","Patents treated with elvitegravir (EVG) 150mg \u002F cobicistat (COBI) 150mg \u002F emtricitabine (FTC) 200mg \u002F tenofovir (TAF) 10mg once a day as the first line treatment.",[9],[21],"TAF\u002FFTC\u002FEVG-cb",null,[24,36,45,51,57,62],{"facility":25,"status":22,"city":26,"state":27,"zip":22,"country":28,"countryCode":29,"cosmosGeoPoint":30,"geoPoint":35,"contacts":22},"Hospital Costa del Sol","Marbella","Malaga","Spain","ES",{"type":31,"coordinates":32},"Point",[33,34],-4.88583,36.51543,{"lat":34,"lon":33},{"facility":37,"status":22,"city":38,"state":22,"zip":39,"country":28,"countryCode":29,"cosmosGeoPoint":40,"geoPoint":44,"contacts":22},"H. Ramón y Cajal","Madrid","28034",{"type":31,"coordinates":41},[42,43],-3.70256,40.4165,{"lat":43,"lon":42},{"facility":46,"status":22,"city":38,"state":22,"zip":47,"country":28,"countryCode":29,"cosmosGeoPoint":48,"geoPoint":50,"contacts":22},"H. Clínico San Carlos","28040",{"type":31,"coordinates":49},[42,43],{"lat":43,"lon":42},{"facility":52,"status":22,"city":38,"state":22,"zip":53,"country":28,"countryCode":29,"cosmosGeoPoint":54,"geoPoint":56,"contacts":22},"H. Doce de Octubre","28041",{"type":31,"coordinates":55},[42,43],{"lat":43,"lon":42},{"facility":58,"status":22,"city":38,"state":22,"zip":22,"country":28,"countryCode":29,"cosmosGeoPoint":59,"geoPoint":61,"contacts":22},"Hospital Infanta Leonor",{"type":31,"coordinates":60},[42,43],{"lat":43,"lon":42},{"facility":63,"status":22,"city":64,"state":22,"zip":65,"country":28,"countryCode":29,"cosmosGeoPoint":66,"geoPoint":70,"contacts":22},"Hospital virgen del Rocío","Seville","41013",{"type":31,"coordinates":67},[68,69],-5.97317,37.38283,{"lat":69,"lon":68},{"type":72,"investigatorFullName":22,"investigatorTitle":22,"investigatorAffiliation":22,"oldNameTitle":22,"oldOrganization":22},"SPONSOR",[74],{"name":75,"class":76},"Merck Sharp & Dohme LLC","INDUSTRY","100338978","phase-4-a-clinical-trial-to-evaluate-the-efficacy-and-safety-of-elvitegravir--cobicistat--emtricitabine--tenofovir-alafenamide-as-a-first-line-treatment-in-nave-patients-with-hiv-1-infection-with-severe-immunosuppression-100338978",false,"NCT03693508","A Clinical Trial to Evaluate the Efficacy and Safety of Elvitegravir \u002F Cobicistat \u002F Emtricitabine \u002F Tenofovir Alafenamide as a First-line Treatment in Naïve Patients With HIV-1 Infection With Severe Immunosuppression","Phase IV, Open, Multicentre, Single-arm Study to Evaluate the Efficacy and Safety of Elvitegravir \u002F Cobicistat \u002F Emtricitabine \u002F Tenofovir Alafenamide as a First-line Treatment in Naïve Patients With HIV-1 Infection With Severe Immunosuppression.","GENIS","Inclusion Criteria:\n\n* Patients able to give their written consent to participate in the study after having received information about the design, the purposes of the study, the possible risks that may arise from it and the possibility of withdrawing from it at any time. moment\n* Adult patients (age ≥18 years) of both sexes\n* Patients with HIV-1 infection with severe immunosuppression, defined by a concentration of CD4 + lymphocytes \\\u003C200 cells \u002F μL\n* Patients who are allowed to perform a genotypic resistance test to inhibitors of intregrase, emtricitabine or tenofovir\n* Creatinine clearance ≥ 30 ml \u002F min before the start of treatment\n* Alanine transaminase (ALT) \u002F Aspartate transaminase (AST) levels not higher than five times normal levels, total bilirubin with normal values, neutrophils\\> 1000 cells \u002F μL,\\> 50000 platelets \u002F μL,\\> Hb level of 85 g \u002F L and serum amylase levels \\\u003C1 , 5 times higher normal limit before the start of treatment\n\nExclusion Criteria:\n\n* Patient who undergoes a concomitant treatment not allowed. Patient with documented intolerance or hypersensitivity to the study medication, or who is contraindicated to use it, attending a technical file\n* Patient receiving therapies with interferon, interleukin 2, cytotoxic chemotherapy or immunosuppressants at the baseline visit.\n* Patients with neoplasms, an exception of skin cancer and anus cancer in situ (stage 0)\n* Patient with any medical or psychological, sociological or geographical alteration, toxic habit (drugs, alcohol) that, a criterion of the researcher, may interfere in the fulfillment of the study by the patient. These conditions will be discussed with the patient before their inclusion in the trial\n* Patients with any medical or psychological alteration that, a criterion of the investigator, an involuntary factor of the patient's ability to understand and complement the questionnaires and scales used in the study\n* Patient in a treatment with any type of drug \u002F product under investigation or who is participating in a clinical trial that uses a product under investigation, with the exception of studies in which the study treatment was completed more than 12 weeks ago\n* Pregnant women, in breastfeeding period or with a positive pregnancy test in the selection period; women of childbearing age and sexually active who are not willing to use an adequate contraceptive method during the study and up to 3 months after the administration of the last dose of study treatment. Some women in adulthood have undergone permanent infertility procedures or amenorrheic procedures for less than 12 months\n* Patients with severe hepatic impairment (Child-Pugh Class C).","ALL","18 Years","100 Years",{"count":89,"type":90},50,"ACTUAL","INTERVENTIONAL",[93],"PHASE4","Phase IV, open, multicentre and single-arm study. 50 HIV infection naive patients with severe immunosuppression will be recruited to evaluate the efficacy and safety of elvitegravir \u002F cobicistat \u002F emtricitabine \u002F tenofovir alafenamide as a first-line treatment.",[96,97],"HIV Infections","Severe Immunosuppression","COMPLETED","2020-08-06",{"date":101,"type":90},"2020-08-07",{"date":103,"type":90},"2018-04-13",{"date":105,"type":90},"2020-05-28",{"name":5,"class":6},6]