[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100532856":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":22,"centralContacts":26,"locations":27,"responsibleParty":131,"collaborators":26,"id":133,"slug":134,"hasResults":135,"nctId":136,"briefTitle":137,"officialTitle":138,"acronym":139,"eligibilityCriteria":140,"healthyVolunteers":141,"sex":142,"minAge":143,"maxAge":26,"enrollmentInfo":144,"targetDuration":26,"studyType":147,"phases":148,"briefSummary":150,"conditions":151,"keywords":153,"overallStatus":161,"whyStopped":26,"lastUpdateSubmitDate":162,"lastUpdatePostDateStruct":163,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":170},{"fullName":5,"class":6},"AbbVie","INDUSTRY",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"BOTOX","EXPERIMENTAL","Participants will receive injections in the glabellar complex, in each of the lateral canthal area, and in the frontalis muscle on Day 1.",[13],"Drug: BOTOX",[15],{"type":16,"name":9,"description":17,"armGroupLabels":18,"otherNames":19},"DRUG","Intramuscular Injections",[9],[20,21],"Botulinum Toxin Type A","OnabotulinumtoxinA",[23],{"name":24,"affiliation":5,"role":25},"ABBVIE INC.","STUDY_DIRECTOR",null,[28,41,51,60,70,80,90,100,112,122],{"facility":29,"status":26,"city":30,"state":31,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":26},"Skin Wellness Dermatology - Homewood \u002FID# 248469","Birmingham","Alabama","35209-8314","United States","US",{"type":36,"coordinates":37},"Point",[38,39],-86.80249,33.52066,{"lat":39,"lon":38},{"facility":42,"status":26,"city":43,"state":44,"zip":45,"country":33,"countryCode":34,"cosmosGeoPoint":46,"geoPoint":50,"contacts":26},"The Research Center at The Maas Clinic \u002FID# 256633","San Francisco","California","94115-1809",{"type":36,"coordinates":47},[48,49],-122.41942,37.77493,{"lat":49,"lon":48},{"facility":52,"status":26,"city":53,"state":44,"zip":54,"country":33,"countryCode":34,"cosmosGeoPoint":55,"geoPoint":59,"contacts":26},"Pacific Clinical Innovations \u002FID# 248467","Vista","92083-6030",{"type":36,"coordinates":56},[57,58],-117.24254,33.20004,{"lat":58,"lon":57},{"facility":61,"status":26,"city":62,"state":63,"zip":64,"country":33,"countryCode":34,"cosmosGeoPoint":65,"geoPoint":69,"contacts":26},"Kavali Plastic Surgery and Skin Renewal Center \u002FID# 248472","Atlanta","Georgia","30328",{"type":36,"coordinates":66},[67,68],-84.38798,33.749,{"lat":68,"lon":67},{"facility":71,"status":26,"city":72,"state":73,"zip":74,"country":33,"countryCode":34,"cosmosGeoPoint":75,"geoPoint":79,"contacts":26},"Tennessee Clinical Research Center \u002FID# 259161","Nashville","Tennessee","37215-2885",{"type":36,"coordinates":76},[77,78],-86.78444,36.16589,{"lat":78,"lon":77},{"facility":81,"status":26,"city":82,"state":83,"zip":84,"country":33,"countryCode":34,"cosmosGeoPoint":85,"geoPoint":89,"contacts":26},"Integrated Aesthetics - Spring \u002FID# 257738","Spring","Texas","77388",{"type":36,"coordinates":86},[87,88],-95.41716,30.07994,{"lat":88,"lon":87},{"facility":91,"status":26,"city":92,"state":93,"zip":94,"country":33,"countryCode":34,"cosmosGeoPoint":95,"geoPoint":99,"contacts":26},"SkinDC \u002FID# 248470","Arlington","Virginia","22209",{"type":36,"coordinates":96},[97,98],-77.10428,38.88101,{"lat":98,"lon":97},{"facility":101,"status":26,"city":102,"state":103,"zip":104,"country":105,"countryCode":106,"cosmosGeoPoint":107,"geoPoint":111,"contacts":26},"Skin Matters Medical Aesthetic Centre \u002FID# 249539","Vancouver","British Columbia","V6M 4J2","Canada","CA",{"type":36,"coordinates":108},[109,110],-123.11934,49.24966,{"lat":110,"lon":109},{"facility":113,"status":26,"city":114,"state":115,"zip":116,"country":105,"countryCode":106,"cosmosGeoPoint":117,"geoPoint":121,"contacts":26},"Project Skin MD - Ottawa \u002FID# 249718","Ottawa","Ontario","K1K 2Z7",{"type":36,"coordinates":118},[119,120],-75.69812,45.41117,{"lat":120,"lon":119},{"facility":123,"status":26,"city":124,"state":115,"zip":125,"country":105,"countryCode":106,"cosmosGeoPoint":126,"geoPoint":130,"contacts":26},"Bertucci MedSpa Inc. \u002FID# 249757","Woodbridge","L4L 8E2",{"type":36,"coordinates":127},[128,129],-79.59962,43.78341,{"lat":129,"lon":128},{"type":132,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100532856","phase-4-a-study-to-evaluate-participant-satisfaction-and-natural-outcomes-following-administration-of-botox-cosmetic-injections-in-adult-participants-for-treatment-of-upper-facial-lines-100532856",true,"NCT06218251","A Study to Evaluate Participant Satisfaction and Natural Outcomes Following Administration of BOTOX Cosmetic Injections in Adult Participants for Treatment of Upper Facial Lines","A Prospective, Multi-center, Open-label Study to Evaluate Subject Satisfaction and Natural Outcomes Following Administration of BOTOX® (Botulinum Toxin Type A) Purified Neurotoxin Complex in Subjects With Upper Facial Lines (Glabellar Lines, Lateral Canthal Lines, and Forehead Lines)","UFL BOND 974","Inclusion Criteria:\n\n* Moderate to severe Glabellar Lines, Lateral Canthal Lines, and Forehead Lines.\n* Sufficient visual acuity without the use of eyeglasses (contact lens use acceptable) to accurately assess their facial wrinkles.\n\nExclusion Criteria:\n\n* Presence or history of any medical condition that may place the participant at increased risk to BOTOX Cosmetic or interfere with the study evaluation.\n* Presence of tattoos, jewelry, or clothing which obscures or interferes with the target area of interest and cannot be removed.\n* History of known immunization or hypersensitivity to any botulinum toxin serotype.",false,"ALL","18 Years",{"count":145,"type":146},100,"ACTUAL","INTERVENTIONAL",[149],"PHASE4","Facial lines that develop from repeated facial expression, such as glabellar lines (GL), lateral canthal lines (LCL), and forehead lines (FHL), are typically treated by selectively weakening specific muscles with small quantities of botulinum toxin. The purpose of this study is to evaluate participant satisfaction and natural outcomes following the administration of BOTOX Cosmetic in adult participants with upper facial lines (GL, LCL, and FHL).\n\nThis is an open-label study in which all participants will receive active study treatment. Around 100 adult participants with an assessment of moderate to severe GL, LCL, and FHL, will be enrolled at approximately 10 sites in the United States and Canada.\n\nParticipants will receive BOTOX Cosmetic as intramuscular injections to the glabellar lines, lateral canthal lines, and forehead lines at Day 1.\n\nParticipants will attend regular visits during the study. The effect of the treatment will be checked by medical assessments for side effects and questionnaires will be completed during regular study visits.",[152],"Upper Facial Lines",[154,155,156,9,20,21,152,157,158,159,160],"Glabellar Lines","Lateral Canthal Lines","Forehead Lines","Crows Feet Lines","Wrinkles","Facial Wrinkles","Facial Rhytides","COMPLETED","2025-11-11",{"date":164,"type":146},"2025-11-24",{"date":166,"type":146},"2024-02-05",{"date":168,"type":146},"2024-12-17",{"name":5,"class":6},10]