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ADVAIR® DISKUS® Inhaler and SEREVENT® DISKUS® Inhaler Are Trademarks of the GSK Group of Companies.","A Randomized, Double-Blind, Parallel Group, 52-Week Study to Compare the Effect of Fluticasone Propionate\u002FSalmeterol DISKUS® Inhaler Combination Product 250\u002F50mcg Twice Daily With Salmeterol DISKUS® Inhaler 50mcg Twice Daily on the Annual Rate of Moderate\u002FSevere Exacerbations in Subjects With Chronic Obstructive Pulmonary Disease (COPD)","Inclusion Criteria:\n\n* Diagnosis of COPD (chronic obstructive pulmonary disease).\n* Current or previous cigarette smokers with a smoking history of at least 10 pack-years.\n* History of a least 1 COPD exacerbation in the 12 months prior to screening.\n* Forced expiratory volume in one second (FEV1) of less than or equal to 50% of predicted normal.\n\nExclusion Criteria:\n\n* Current diagnosis of asthma.\n* Additional respiratory disorders other than COPD (eg, sarcoidosis, alpha-1 antitrypsin deficiency, cystic fibrosis, or active tuberculosis).\n* Concurrent use of long-acting beta-agonists, long-acting anticholinergics, inhaled and oral corticosteroids, theophylline, investigational medications, ritonavir, and anti-leukotrienes.\n* Lung resection surgery within 1 year of screening.\n* Abnormal and clinically significant ECG findings at screening.\n* Other inclusion and exclusion criteria will be evaluated at the first study visit.","ALL","40 Years",{"count":837,"type":838},740,"ACTUAL","INTERVENTIONAL",[841],"PHASE4","This study evaluates the effect of two medicines on COPD (Chronic Obstructive Pulmonary Disease) exacerbations. 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