[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100115305":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":36,"responsibleParty":48,"collaborators":35,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":35,"eligibilityCriteria":56,"healthyVolunteers":52,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":35,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":70,"overallStatus":75,"whyStopped":35,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Johnson & Johnson Taiwan Ltd","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Tramadol\u002FAcetaminophen","EXPERIMENTAL","Participants will receive a combination tablet of 37.5 milligram (mg) tramadol and 325 mg acetaminophen, orally twice daily up to 8 weeks.",[13],"Drug: Tramadol \u002Facetaminophen",{"label":15,"type":16,"description":17,"interventionNames":18},"Diclofenac","ACTIVE_COMPARATOR","Participants will receive 50 mg diclofenac tablet, orally twice daily up to 8 weeks.",[19],"Drug: Diclofenac",[21,27],{"type":22,"name":23,"description":11,"armGroupLabels":24,"otherNames":25},"DRUG","Tramadol \u002Facetaminophen",[9],[26],"Ultracet®",{"type":22,"name":15,"description":17,"armGroupLabels":28,"otherNames":29},[15],[30],"Voltaren®",[32],{"name":33,"affiliation":5,"role":34},"Johnson & Johnson Taiwan, Ltd. Clinical Trial","STUDY_DIRECTOR",null,[37],{"facility":38,"status":35,"city":39,"state":35,"zip":35,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":35},"Johnson & Johnson Taiwan Ltd.","Taipei","Taiwan","TW",{"type":43,"coordinates":44},"Point",[45,46],121.52639,25.05306,{"lat":46,"lon":45},{"type":49,"investigatorFullName":35,"investigatorTitle":35,"investigatorAffiliation":35,"oldNameTitle":35,"oldOrganization":35},"SPONSOR","100115305","phase-4-an-efficacy-and-safety-study-of-tramadolacetaminophen-versus-diclofenac-in-the-treatment-of-pain-in-participants-with-ankylosing-spondylitis-receiving-stable-treatment-of-disease-modifying-anti-rheumatic-drugs-dmards-100115305",false,"NCT00766402","An Efficacy and Safety Study of Tramadol\u002FAcetaminophen Versus Diclofenac in the Treatment of Pain in Participants With Ankylosing Spondylitis Receiving Stable Treatment of Disease Modifying Anti-rheumatic Drugs (DMARDs)","A Study to Evaluate the Clinical Benefits of Tramadol\u002FAcetaminophen (Ultracet®) vs. Diclofenac (Voltaren®) in the Treatment of Pain in Patients With Ankylosing Spondylitis Receiving Stable Treatment of Disease Modifying Anti-rheumatic Drugs (DMARDs)","Inclusion Criteria:\n\n* Diagnosis of ankylosing spondylitis (AS), as defined by Modified New York Criteria for ankylosing spondylitis: a) Low-back pain of at least 3 months duration improved by exercise and not relieved by rest b) Limitation of lumbar spine in sagittal and frontal planes c) Chest expansion decreased relative to normal values for age and sex d) Bilateral sacroiliitis, grade 2-4 or Unilateral sacroiliitis, grade 3-4 (Stoke)\n* Participants are suffering from pain, with visual analogue scale (VAS) pain score greater than or equal to (\\>=) 40 millimeter (mm)\n* Participants are receiving disease modifying anti-rheumatic drugs (DMARDs), which have reached to the stable dosage within 4 weeks prior to the randomization visit - Serum creatinine less than or equal to (\\\u003C=) 1.2 milligram per deciliter (mg\u002FdL)\n* Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) \\\u003C= 3 times the laboratory's upper limit of normal\n* Exclusion Criteria:\n* Had an inadequate response to tramadol hydrochloride (HCl) therapy, or have discontinued tramadol HCl therapy due to adverse events\n* Have taken tramadol HCl within 4 weeks prior to the entry of the study\n* Have taken other medications for pain relief within 4 weeks prior to the entry of the study, except rescue medications\n* Evidence of significant uncontrolled concomitant diseases such as cardiovascular disease, nervous system, pulmonary, renal, hepatic, endocrine or gastrointestinal disorders\n* Women with pregnancy or breast-feeding","ALL","18 Years","70 Years",{"count":61,"type":62},8,"ACTUAL","INTERVENTIONAL",[65],"PHASE4","The purpose of the study is to investigate the clinical benefit of tramadol\u002Facetaminophen versus non-steroidal anti-inflammatory drugs (NSAID) (diclofenac 50 milligram \\[mg\\]) in the treatment of pain in participants with ankylosing spondylitis (inflammation of the spine causing pain and stiffness) receiving stable treatment of disease modifying anti-rheumatic drugs (DMARDs).",[68,69],"Spondylitis, Ankylosing","Pain",[71,69,72,15,73,74],"Spondylitis, ankylosing","Ultracet","Voltaren","Tramadol\u002Facetaminophen","TERMINATED","2026-06-02",{"date":78,"type":62},"2026-06-04",{"date":80,"type":62},"2008-09-01",{"date":82,"type":62},"2009-03-26",{"name":5,"class":6},1]