[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100503381":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":32,"centralContacts":32,"locations":33,"responsibleParty":44,"collaborators":32,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":32,"eligibilityCriteria":54,"healthyVolunteers":50,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":32,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":32,"overallStatus":67,"whyStopped":32,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":76},{"fullName":5,"class":6},"Ain Shams University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"hyaluronic acid\u002F scaling","EXPERIMENTAL","topical application of hyaluronic acid after scaling by 1 day",[13,14],"Drug: Hyaluronic acid","Procedure: non surgical periodontal therapy",{"label":16,"type":10,"description":17,"interventionNames":18},"scaling","scaling only",[14],[20,27],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Hyaluronic acid","Hyaluronic Acid (HA) is an addition to the local chemotherapeutic agents. Hyaluronic acid was discovered by Meyer and Palmer. HA is widely found in the extracellular matrix and it plays an essential role in controlling cell behavior including random motility, metabolic reactions, chemotaxis, proliferation and invasion. HA is released by many cells including fibroblasts",[9],[26],"hyaluronan",{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"PROCEDURE","non surgical periodontal therapy","NSPT, with or without adjunctive therapies, is an effective treatment for periodontitis. It reduces PD and results in formation of some new attachment; however, it also has several limitations, and surgical therapy might be required to control inflammation and optimize outcomes. When used for non-surgical scaling and root planing, periodontal curettes can reach a mean PD of up to approximately 5.5 mm. The mean PD in which a plaque-free and calculus-free surface can be established is \\\u003C4 mm",[9,16],null,[34],{"facility":35,"status":32,"city":35,"state":32,"zip":32,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":32},"Cairo","Egypt","EG",{"type":39,"coordinates":40},"Point",[41,42],31.24967,30.06263,{"lat":42,"lon":41},{"type":45,"investigatorFullName":46,"investigatorTitle":47,"investigatorAffiliation":5,"oldNameTitle":32,"oldOrganization":32},"SPONSOR_INVESTIGATOR","Ehab Haider Hassan El-emam","ehab haider hassan elemam","100503381","phase-4-efficacy-of-locally-delivered-hyaluronic-acid-gel-as-an-adjunctive-to-non-surgical-management-of-periodontitis-100503381",false,"NCT05834517","''Efficacy of Locally Delivered Hyaluronic Acid Gel as an Adjunctive to Non-Surgical Management of Periodontitis","''Efficacy of Locally Delivered Hyaluronic Acid Gel as an Adjunctive to Non-Surgical Management of Stage II or Stage III Periodontitis","Inclusion Criteria:\n\n.Patients have to be free from any systemic disease as proven by Burket's oral medicine health history questionnaire (Glik et al., 2008).\n\n.Both genders aged 20-55.\n\n. Periodontitis (Stage II or stage III) Patients; (3-6 mm CAL ,pocket depth ≤7 mm, mostly horizontal 15%-33% bone loss as assessed by preoperative radiographs with no tooth loss due to periodontitis) (Tonetti et al., 2017).\n\nExclusion Criteria:\n\n* Pregnant lactating females\n* Smoking\n* Patients who can't be committed to oral hygiene instructions\n* History of periodontal surgery or antimicrobial therapy for at least 4 months.","ALL","25 Years","55 Years",{"count":59,"type":60},28,"ACTUAL","INTERVENTIONAL",[63],"PHASE4","Hyaluronic Acid (HA) is an addition to the local chemotherapeutic agents. Hyaluronic acid was discovered by Meyer and Palmer. HA is widely found in the extracellular matrix and it plays an essential role in controlling cell behavior including random motility, metabolic reactions, chemotaxis, proliferation and invasion. HA is released by many cells including fibroblasts (Dahiya et al., 2013).\n\nHyaluronic acid can be found in the skin, eyes and the periodontium. In addition, it appears in body fluids like serum, gingival crevicular fluid and saliva. Hyaluronic acid is created in the periodontium by HA synthase enzyme present in numerous cells like fibroblast and cementoblast (Fraser et al., 1997).\n\nThere is evidence that hyaluronic acid is bacteriostatic, fungostatic, anti-inflammatory, osteoconduvtive and pro-angiogenic. These dissimilar properties illustrate the ability of hyaluronic acid to be an ideal material for wound healing (Carlson et al., 2004).",[66],"Periodontitis","COMPLETED","2023-04-27",{"date":70,"type":60},"2023-04-28",{"date":72,"type":60},"2022-05-02",{"date":74,"type":60},"2022-12-10",{"name":46,"class":6},1]