[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100352038":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":18,"locations":29,"responsibleParty":154,"collaborators":156,"id":161,"slug":162,"hasResults":163,"nctId":164,"briefTitle":165,"officialTitle":166,"acronym":167,"eligibilityCriteria":168,"healthyVolunteers":163,"sex":169,"minAge":170,"maxAge":18,"enrollmentInfo":171,"targetDuration":18,"studyType":174,"phases":175,"briefSummary":177,"conditions":178,"keywords":180,"overallStatus":184,"whyStopped":185,"lastUpdateSubmitDate":186,"lastUpdatePostDateStruct":187,"startDateStruct":189,"completionDateStruct":191,"leadSponsor":193,"locationsCount":194},{"fullName":5,"class":6},"University College, London","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Telemetric Bluetooth-enabled home BP monitors","EXPERIMENTAL","Telemetric Bluetooth home BP monitors will be provided to participants during their inpatient stay or clinic visit, and will commence 3- times-daily readings immediately. The BP monitoring team will assess BP readings daily and advise medication adjustments to achieve a target BP of \\\u003C120\u002F80 mm Hg",[13],"Device: A&D BP Digital Blood Pressure Monitor (UA-767PBT-Ci) CE Declaration UA-767PBT-Ci",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard clinical care","NO_INTERVENTION","Standard clinical care including usual BP treatment, without home monitoring, undertaken in the clinical care setting (primary and\u002For secondary care)",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"DEVICE","A&D BP Digital Blood Pressure Monitor (UA-767PBT-Ci) CE Declaration UA-767PBT-Ci","Telemetric home monitoring is a promising strategy to facilitate home BP monitoring after stroke, which should improve adherence and optimize medication to better control BP. Telemetry allows patients with hypertension to monitor their own BP and automatically send the information to a secure website, available to their clinicians to monitor and adjust their treatment.",[9],[26],{"name":27,"affiliation":5,"role":28},"David Werring","STUDY_CHAIR",[30,41,49,57,65,73,82,88,94,100,105,113,121,129,138,146],{"facility":31,"status":18,"city":32,"state":18,"zip":18,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":18},"Royal United Hospitals Bath","Bath","United Kingdom","UK",{"type":36,"coordinates":37},"Point",[38,39],-2.36172,51.3751,{"lat":39,"lon":38},{"facility":42,"status":18,"city":43,"state":18,"zip":18,"country":33,"countryCode":34,"cosmosGeoPoint":44,"geoPoint":48,"contacts":18},"West Suffolk Hospital","Bury St Edmunds",{"type":36,"coordinates":45},[46,47],0.71111,52.2463,{"lat":47,"lon":46},{"facility":50,"status":18,"city":50,"state":18,"zip":51,"country":33,"countryCode":34,"cosmosGeoPoint":52,"geoPoint":56,"contacts":18},"Cambridge","CB2 0QQ",{"type":36,"coordinates":53},[54,55],0.11667,52.2,{"lat":55,"lon":54},{"facility":58,"status":18,"city":58,"state":18,"zip":59,"country":33,"countryCode":34,"cosmosGeoPoint":60,"geoPoint":64,"contacts":18},"Edinburgh","EH16 4SB",{"type":36,"coordinates":61},[62,63],-3.19648,55.95206,{"lat":63,"lon":62},{"facility":66,"status":18,"city":66,"state":18,"zip":67,"country":33,"countryCode":34,"cosmosGeoPoint":68,"geoPoint":72,"contacts":18},"Glasgow","G51 4TF",{"type":36,"coordinates":69},[70,71],-4.25763,55.86515,{"lat":71,"lon":70},{"facility":74,"status":18,"city":75,"state":18,"zip":76,"country":33,"countryCode":34,"cosmosGeoPoint":77,"geoPoint":81,"contacts":18},"King's","London","SE5 8AF",{"type":36,"coordinates":78},[79,80],-0.12574,51.50853,{"lat":80,"lon":79},{"facility":83,"status":18,"city":75,"state":18,"zip":84,"country":33,"countryCode":34,"cosmosGeoPoint":85,"geoPoint":87,"contacts":18},"St George's","SW17 0QT",{"type":36,"coordinates":86},[79,80],{"lat":80,"lon":79},{"facility":89,"status":18,"city":75,"state":18,"zip":90,"country":33,"countryCode":34,"cosmosGeoPoint":91,"geoPoint":93,"contacts":18},"Imperial","W12 0HS",{"type":36,"coordinates":92},[79,80],{"lat":80,"lon":79},{"facility":95,"status":18,"city":75,"state":18,"zip":96,"country":33,"countryCode":34,"cosmosGeoPoint":97,"geoPoint":99,"contacts":18},"UCLH","WC1B 5EH",{"type":36,"coordinates":98},[79,80],{"lat":80,"lon":79},{"facility":101,"status":18,"city":75,"state":18,"zip":18,"country":33,"countryCode":34,"cosmosGeoPoint":102,"geoPoint":104,"contacts":18},"Croydon University Hospital",{"type":36,"coordinates":103},[79,80],{"lat":80,"lon":79},{"facility":106,"status":18,"city":107,"state":18,"zip":18,"country":33,"countryCode":34,"cosmosGeoPoint":108,"geoPoint":112,"contacts":18},"Luton & Dunstable Hospital","Luton",{"type":36,"coordinates":109},[110,111],-0.41748,51.87967,{"lat":111,"lon":110},{"facility":114,"status":18,"city":114,"state":18,"zip":115,"country":33,"countryCode":34,"cosmosGeoPoint":116,"geoPoint":120,"contacts":18},"Nottingham","NG5 1PB",{"type":36,"coordinates":117},[118,119],-1.15047,52.9536,{"lat":119,"lon":118},{"facility":122,"status":18,"city":122,"state":18,"zip":123,"country":33,"countryCode":34,"cosmosGeoPoint":124,"geoPoint":128,"contacts":18},"Oxford","OX3 9DU",{"type":36,"coordinates":125},[126,127],-1.25596,51.75222,{"lat":127,"lon":126},{"facility":130,"status":18,"city":131,"state":18,"zip":132,"country":33,"countryCode":34,"cosmosGeoPoint":133,"geoPoint":137,"contacts":18},"Royal Preston","Preston","PR2 9HT",{"type":36,"coordinates":134},[135,136],-2.70452,53.76282,{"lat":136,"lon":135},{"facility":139,"status":18,"city":139,"state":18,"zip":140,"country":33,"countryCode":34,"cosmosGeoPoint":141,"geoPoint":145,"contacts":18},"Salford","M6 8HD",{"type":36,"coordinates":142},[143,144],-2.29042,53.48771,{"lat":144,"lon":143},{"facility":147,"status":18,"city":147,"state":18,"zip":148,"country":33,"countryCode":34,"cosmosGeoPoint":149,"geoPoint":153,"contacts":18},"Sheffield","S10 2JF",{"type":36,"coordinates":150},[151,152],-1.4659,53.38297,{"lat":152,"lon":151},{"type":155,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR",[157,159],{"name":158,"class":6},"University of Oxford",{"name":160,"class":6},"The Stroke Association, United Kingdom","100352038","prevention-of-hypertensive-injury-to-the-brain-by-intensive-treatment-of-blood-pressure-after-intracerebral-haemorrhage-prohibit-ich-100352038",false,"NCT03863665","Prevention of Hypertensive Injury to the Brain by Intensive Treatment of Blood Pressure After Intracerebral Haemorrhage (PROHIBIT-ICH)","Prevention of Hypertensive Injury to the Brain by Intensive Treatment of Blood Pressure After Intracerebral Haemorrhage","PROHIBIT-ICH","Inclusion Criteria:\n\n1. Adults (≥30 years) with spontaneous primary ICH (i.e. without known underlying structural, macrovascular or other cause (e.g. arteriovenous malformation, tumour) after adequate investigation at the discretion of the local investigator). This will include participants presumed to have cerebral SVD (both hypertensive arteriopathy and cerebral amyloid angiopathy)\n2. Clinical team opinion that BP control since the ICH is not adequate AND the measured SBP prior to randomisation is ≥130 mm Hg\n3. There is no time limit for recruitment; however, recruitment as soon as is practical after the ICH is encouraged. Recruitment at a later stage is acceptable as long as there is evidence of inadequate BP control AND SBP at randomisation is ≥130 mm Hg\n4. Ability and willingness to undertake BP measurements,, either unassisted or with the help of a relative, friend or carer: this can be undertaken in any destination after hospital discharge (e.g. home, rehabilitation unit, nursing or care home)\n5. Ability and willingness to attend and complete the study assessments including cognitive screen\n6. Ability and willingness to provide informed consent, or with a suitable consultee available and able to participate in the intervention (e.g. with a motivated carer)\n\nExclusion Criteria:\n\n1. Inability to provide informed consent or lack of suitable consultee (if unable to provide personal consent, lack of suitable consultee)\n2. Evidence of a macrovascular or structural cause for ICH (e.g. AVM or tumour)\n3. Diagnosis of dementia (DSM IV criteria, or self-reported or documented in medical records)\n4. Low Functional status (MRS ≥4) before or after ICH or frailty likely to make participation in 1-year follow-up difficult for the participant\n5. Life expectancy \\\u003C2 years\n6. Taking more than 2 BP-lowering medications (i.e. 3 or more) at the time of consent\n7. Consistently good BP control (below 130\u002F80 mm Hg on measures taken as part of routine clinical care) prior to planned recruitment, judged not to require more intensive treatment\n8. Known flow-restricting intracranial\u002Fextracranial large arterial stenosis\n9. Known absence of mobile phone coverage from all network operators and home internet at the participant's home\n10. Known sensitivity or contra-indication to BP treatments (e.g. symptomatic postural hypotension) is not an absolute exclusion criterion, but more information must be provided\n11. Note that participation in other CTIMP or device trial is NOT an automatic exclusion criterion","ALL","30 Years",{"count":172,"type":173},86,"ACTUAL","INTERVENTIONAL",[176],"NA","PROHIBIT-ICH will randomise participants (target=112) to compare a strategy of intensive blood pressure (BP) treatment (target \\\u003C120\u002F80 mm Hg) guided by remote telemetric home BP monitoring, versus standard primary care, in adult survivors of small vessel disease-related ICH. The investigators will establish the feasibility and safety of the intervention, the efficacy of BP reduction, and explore whether it reduces the progression of SVD-related injury on brain MRI.",[179],"Intracerebral Hemorrhage",[181,182,183],"Blood pressure","Hypertension","Secondary prevention","TERMINATED","Imposed by the sponsor due to funding constraints","2024-12-05",{"date":188,"type":173},"2024-12-10",{"date":190,"type":173},"2019-03-11",{"date":192,"type":173},"2023-04-29",{"name":5,"class":6},16]