[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100255028":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":32,"centralContacts":36,"locations":45,"responsibleParty":63,"collaborators":27,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":27,"eligibilityCriteria":73,"healthyVolunteers":69,"sex":74,"minAge":27,"maxAge":75,"enrollmentInfo":76,"targetDuration":27,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":86,"overallStatus":88,"whyStopped":27,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Daping Hospital and the Research Institute of Surgery of the Third Military Medical University","OTHER",[8,14,18],{"label":9,"type":6,"description":10,"interventionNames":11},"ALI( acute lung injury)","Diagnostic criteria: 1.Acute onset；2.FiO2\u002F PaO2\\\u003C 40.0 kPa (300mmHg, ALI); 3.Chest X-ray showed that the double lung texture increased, the increase of crude, fuzzy, visible diffuse patchy infiltration shadow with compensatory emphysema, for the most early performance; B. double lung field large sheet, asymmetric, edge fuzzy infiltration shadow, the most dense in the lung；4. Echocardiography, left atrial hypertension; 5.The gestational age \\>35 week, have maternal age cholestasis (severe), sepsis or meconium aspiration syndrome (MAS) understanding of history, and with the exception of the primary pulmonary surfactant (PS) lack of. FXR and RIPK3 were measured in neonate with ALI.",[12,13],"Other: FXR","Other: RIPK3",{"label":15,"type":6,"description":16,"interventionNames":17},"ARDS(respiratory distress syndrome)","ARDS :Diagnostic criteria: 1.Acute onset；2.FiO2\u002F PaO2\\\u003C 26.7 kPa (200mmHg, ARDS); 3.Chest X-ray showed that the double lung transparent brightness is generally lower, the glass sample, with bronchial inflatable sign, and even double lung field common density increased, the heart shadow is not clear, a white lung, as the most important performance；4. Echocardiography, left atrial hypertension; 5.The gestational age \\>35 week, have maternal age cholestasis (severe), sepsis or meconium aspiration syndrome (MAS) understanding of history, and with the exception of the primary pulmonary surfactant (PS) lack of；6.Need to use a ventilator.\n\nFXR and RIPK3 were measured in neonate with ALI.were measured in another group neonate with ARDS",[12,13],{"label":19,"type":6,"description":20,"interventionNames":21},"control","Control group: Patients with mechanical ventilation due to external causes of the lung, no ALI-ARDS performance,FiO2\u002F PaO2\\\u003C 40.0 kPa (300 mmHg), such as premature apnea or HIE. FXR and RIPK3 were measured in neonate with HIE",[12,13],[23,28],{"type":6,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"FXR","FXR could elevate the transcription of RIPK3, a key protein in necroptosis, and play important role in bile aicd induced alveolar epithelial cell(AEC) necroptosis. FXR were measured in neonate with ALI、ARDS and control",[9,15,19],null,{"type":6,"name":29,"description":30,"armGroupLabels":31,"otherNames":27},"RIPK3","FXR(farnesoid-X-receptor) could elevate the transcription of RIPK3, a key protein in necroptosis, and play important role in bile aicd induced alveolar epithelial cell(AEC) necroptosis. RIPK3 were measured in neonate with ALI、ARDS and control.",[9,15,19],[33],{"name":34,"affiliation":5,"role":35},"Hu Zh Xue, Doctorate","STUDY_DIRECTOR",[37,42],{"name":38,"role":39,"phone":40,"phoneExt":27,"email":41},"Wu Fang, Bachelor","CONTACT","00862318696670405","liuchengchun001@163.com",{"name":43,"role":39,"phone":44,"phoneExt":27,"email":27},"Hu Zh Xue, Bachelor","00862318696668598",[46],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"NICU of Daping Hospital of the Third Military Medical University","RECRUITING","Chongqing","Chongqing Municipality","400042","China","CN",{"type":55,"coordinates":56},"Point",[57,58],106.55771,29.56026,{"lat":58,"lon":57},[61],{"name":62,"role":39,"phone":40,"phoneExt":27,"email":27},"WU FANG, Bachelor",{"type":64,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":27,"oldOrganization":27},"PRINCIPAL_INVESTIGATOR","Fang Wu","Principal Investigator Fang Wu","100255028","role-and-molecular-mechanism-of-farnesoid-x-receptorfxr-and-ripk3-in-the-formation-of-acute-respiratory-distress-syndrome-in-neonates-100255028",false,"NCT02598648","Role and Molecular Mechanism of Farnesoid X Receptor(FXR) and RIPK3 in the Formation of Acute Respiratory Distress Syndrome in Neonates","Daping Hospital of the Third Military Medical University","Inclusion Criteria:According to the diagnostic criteria, the diagnosis was ALI or ARDS； Exclusion Criteria:Severe congenital or hereditary disease of the newborn, is clearly diagnosed as NRDS, which is caused by the lack of the primary PS。","ALL","1 Week",{"count":77,"type":78},40,"ESTIMATED","INTERVENTIONAL",[81],"NA","In the clinical data, the changes of RIPK3 and FXR were monitored in the lung lavage fluid and blood from the patients.\n\nIn vivo experiments to find high risk factors to induce AEC necrosis and further lead to ARDS evidence, can provide a more direct theoretical research foundation for the pathogenesis of ARDS.",[84,85,24,29],"Acute Respiratory Distress Syndrome","Acute Lung Injury",[24,29,87,84,85],"Neonates","UNKNOWN","2022-10-13",{"date":91,"type":92},"2022-10-14","ACTUAL",{"date":94,"type":27},"2015-09-20",{"date":96,"type":78},"2023-09-30",{"name":5,"class":6},1]