[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100484378":3},{"organization":4,"armGroups":7,"interventions":30,"overallOfficials":48,"centralContacts":53,"locations":48,"responsibleParty":59,"collaborators":48,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":48,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":48,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":48,"overallStatus":82,"whyStopped":48,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":48},{"fullName":5,"class":6},"Assiut University","OTHER",[8,14,19,24],{"label":9,"type":10,"description":11,"interventionNames":12},"Group 1","EXPERIMENTAL","six sessions of fractional carbon dioxide laser every 2 weeks will be done for 15 patients with alopecia areata followed immediately by topical application of minoxidil 5%",[13],"Device: Fractional CO2 laser",{"label":15,"type":10,"description":16,"interventionNames":17},"Group 2","six sessions of microneedling evry 2 weeks will be done for 15 patients with alopecia areata followed immediately by topical application of minoxidil 5%",[18],"Device: Derma pen",{"label":20,"type":10,"description":21,"interventionNames":22},"Group 3","15 patient of alopecia areata that will be treated by topical nanominoxidil for 3 months.",[23],"Drug: Niosome minoxidil",{"label":25,"type":26,"description":27,"interventionNames":28},"Group 4","ACTIVE_COMPARATOR","15 patient of alopecia areata that will be treated by topical minoxidil 5% for 3 months",[29],"Drug: Minoxidil Topical Spray",[31,38,43,49],{"type":32,"name":33,"description":34,"armGroupLabels":35,"otherNames":36},"DEVICE","Fractional CO2 laser","Each patient will receive 6 sessions 2 weeks apart, after the laser treatment, a topical 5% minoxidil tincture will immediately applied.\n\nAll patients will advised not to use any other treatment during the study",[9],[37],"Drug",{"type":32,"name":39,"description":40,"armGroupLabels":41,"otherNames":42},"Derma pen",", will be treated by microneedling using dermapen ( automated Derma Pen, DR Pen Ultima A6, China) which under complete aseptic precaution with a cartridge containing 12 needles moved diagonally, vertically, and horizontally for 4-5 times in each direction with 1.5 mm depth and speed 4-5(new cartridge every session), the application has been extended 1-2 cm perilesionally. The pinpoint bleeding will be considered an endpoint. topical 5% minoxidil tincture will immediately applied. Each patient will receive 6 sessions 2 weeks apart.",[15],[37],{"type":44,"name":45,"description":46,"armGroupLabels":47,"otherNames":48},"DRUG","Niosome minoxidil","The patient of alopecia areata will be treated by topical nanominoxidil preparation twice daily for 3 months with no other treatment.",[20],null,{"type":44,"name":50,"description":51,"armGroupLabels":52,"otherNames":48},"Minoxidil Topical Spray","The patient of alopecia areata will be treated by topical minoxidil 5% preparation twice daily for 3 months with no other treatment.",[25],[54],{"name":55,"role":56,"phone":57,"phoneExt":48,"email":58},"Ahmed Elsayed, Master","CONTACT","+20 1000520295","Ahmed.alsaid@med.aun.eg",{"type":60,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":48,"oldOrganization":48},"PRINCIPAL_INVESTIGATOR","Ahmed Elsayed Mohamed","Assistant Lecturer","100484378","role-of-minoxidil-in-alopecia-areata-transepidermal-drug-delivery-of-minoxidil-via-either-fractional-carbon-dioxide-laser-or-microneedling-versus-its-topical-nanoparticles-preparation-for-treatment-of-alopecia-areata-100484378",false,"NCT05587257","Role of Minoxidil in Alopecia Areata Transepidermal Drug Delivery of Minoxidil Via Either Fractional Carbon Dioxide Laser or Microneedling Versus Its Topical Nanoparticles Preparation for Treatment of Alopecia Areata","Transepidermal Drug Delivery of Minoxidil Via Either Fractional Carbon Dioxide Laser or Microneedling Versus Its Topical Nanoparticles Preparation for Treatment of Alopecia Areata","Inclusion Criteria:\n\n* The study will include patients with alopecia areata\n\nExclusion Criteria:\n\n* Children below 18 years , pregnant and lactating women . patients with chronic hepatic, hematological disorders or immunocompromised patients.\n\npatient recieved any treatment for alopecia areata in the last 3 months before the study.\n\npatients with extensive types (alopecia totalis, universalis and surface area \\>50%).","ALL","10 Years","50 Years",{"count":74,"type":75},60,"ESTIMATED","INTERVENTIONAL",[78],"NA","* Compare the clinical efficacy, and safety of transepidermal drug delivery of fractional CO2 laser versus microneedling followed by minoxidil 5% application for the treatment of alopecia areata.\n* Evaluate the efficacy, and safety of minoxidil nanoparticles as a topical treatment of alopecia areata.",[81],"Alopecia Areata","UNKNOWN","2022-10-16",{"date":85,"type":86},"2022-10-20","ACTUAL",{"date":88,"type":75},"2023-01-01",{"date":90,"type":75},"2024-02-01",{"name":5,"class":6}]