[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100059424":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":7,"locations":13,"responsibleParty":175,"collaborators":177,"id":180,"slug":181,"hasResults":182,"nctId":183,"briefTitle":184,"officialTitle":185,"acronym":7,"eligibilityCriteria":186,"healthyVolunteers":182,"sex":187,"minAge":188,"maxAge":189,"enrollmentInfo":190,"targetDuration":7,"studyType":192,"phases":7,"briefSummary":193,"conditions":194,"keywords":196,"overallStatus":208,"whyStopped":7,"lastUpdateSubmitDate":209,"lastUpdatePostDateStruct":210,"startDateStruct":7,"completionDateStruct":213,"leadSponsor":216,"locationsCount":217},{"fullName":5,"class":6},"National Institute of Allergy and Infectious Diseases (NIAID)","NIH",null,[9],{"name":10,"affiliation":11,"role":12},"William Borkowsky, MD","New York University Medical Center, Pediatric Infectious Diseases","STUDY_CHAIR",[14,27,37,47,57,67,77,87,97,106,112,118,127,136,145,154,164],{"facility":15,"status":7,"city":16,"state":17,"zip":18,"country":19,"countryCode":20,"cosmosGeoPoint":21,"geoPoint":26,"contacts":7},"Los Angeles County - USC Med Ctr","Los Angeles","California","90033","United States","US",{"type":22,"coordinates":23},"Point",[24,25],-118.24368,34.05223,{"lat":25,"lon":24},{"facility":28,"status":7,"city":29,"state":30,"zip":31,"country":19,"countryCode":20,"cosmosGeoPoint":32,"geoPoint":36,"contacts":7},"Children's Hosp of Denver","Denver","Colorado","802181088",{"type":22,"coordinates":33},[34,35],-104.9847,39.73915,{"lat":35,"lon":34},{"facility":38,"status":7,"city":39,"state":40,"zip":41,"country":19,"countryCode":20,"cosmosGeoPoint":42,"geoPoint":46,"contacts":7},"Howard Univ Hosp","Washington D.C.","District of Columbia","20060",{"type":22,"coordinates":43},[44,45],-77.03637,38.89511,{"lat":45,"lon":44},{"facility":48,"status":7,"city":49,"state":50,"zip":51,"country":19,"countryCode":20,"cosmosGeoPoint":52,"geoPoint":56,"contacts":7},"Univ of Miami (Pediatric)","Miami","Florida","33161",{"type":22,"coordinates":53},[54,55],-80.19366,25.77427,{"lat":55,"lon":54},{"facility":58,"status":7,"city":59,"state":60,"zip":61,"country":19,"countryCode":20,"cosmosGeoPoint":62,"geoPoint":66,"contacts":7},"Chicago Children's Memorial Hosp","Chicago","Illinois","606143394",{"type":22,"coordinates":63},[64,65],-87.65005,41.85003,{"lat":65,"lon":64},{"facility":68,"status":7,"city":69,"state":70,"zip":71,"country":19,"countryCode":20,"cosmosGeoPoint":72,"geoPoint":76,"contacts":7},"Johns Hopkins Hosp - Pediatric","Baltimore","Maryland","21287",{"type":22,"coordinates":73},[74,75],-76.61219,39.29038,{"lat":75,"lon":74},{"facility":78,"status":7,"city":79,"state":80,"zip":81,"country":19,"countryCode":20,"cosmosGeoPoint":82,"geoPoint":86,"contacts":7},"Children's Hosp of Boston","Boston","Massachusetts","021155724",{"type":22,"coordinates":83},[84,85],-71.05977,42.35843,{"lat":85,"lon":84},{"facility":88,"status":7,"city":89,"state":90,"zip":91,"country":19,"countryCode":20,"cosmosGeoPoint":92,"geoPoint":96,"contacts":7},"Univ of Medicine & Dentistry of New Jersey \u002F Univ Hosp","Newark","New Jersey","071032714",{"type":22,"coordinates":93},[94,95],-74.17237,40.73566,{"lat":95,"lon":94},{"facility":98,"status":7,"city":99,"state":99,"zip":100,"country":19,"countryCode":20,"cosmosGeoPoint":101,"geoPoint":105,"contacts":7},"St. Lukes\u002FRoosevelt Hosp Ctr","New York","10025",{"type":22,"coordinates":102},[103,104],-74.00597,40.71427,{"lat":104,"lon":103},{"facility":107,"status":7,"city":99,"state":99,"zip":108,"country":19,"countryCode":20,"cosmosGeoPoint":109,"geoPoint":111,"contacts":7},"Columbia Presbyterian Med Ctr","10032",{"type":22,"coordinates":110},[103,104],{"lat":104,"lon":103},{"facility":113,"status":7,"city":99,"state":99,"zip":114,"country":19,"countryCode":20,"cosmosGeoPoint":115,"geoPoint":117,"contacts":7},"Harlem Hosp Ctr","10037",{"type":22,"coordinates":116},[103,104],{"lat":104,"lon":103},{"facility":119,"status":7,"city":120,"state":99,"zip":121,"country":19,"countryCode":20,"cosmosGeoPoint":122,"geoPoint":126,"contacts":7},"University of Rochester Medical Center","Rochester","14642-0001",{"type":22,"coordinates":123},[124,125],-77.61556,43.15478,{"lat":125,"lon":124},{"facility":128,"status":7,"city":129,"state":99,"zip":130,"country":19,"countryCode":20,"cosmosGeoPoint":131,"geoPoint":135,"contacts":7},"State Univ of New York at Stony Brook","Stony Brook","117948111",{"type":22,"coordinates":132},[133,134],-73.14094,40.92565,{"lat":134,"lon":133},{"facility":137,"status":7,"city":138,"state":99,"zip":139,"country":19,"countryCode":20,"cosmosGeoPoint":140,"geoPoint":144,"contacts":7},"SUNY Health Sciences Ctr at Syracuse \u002F Pediatrics","Syracuse","13210",{"type":22,"coordinates":141},[142,143],-76.14742,43.04812,{"lat":143,"lon":142},{"facility":146,"status":7,"city":147,"state":99,"zip":148,"country":19,"countryCode":20,"cosmosGeoPoint":149,"geoPoint":153,"contacts":7},"Bronx Lebanon Hosp Ctr","The Bronx","10457",{"type":22,"coordinates":150},[151,152],-73.86641,40.84985,{"lat":152,"lon":151},{"facility":155,"status":7,"city":156,"state":157,"zip":158,"country":19,"countryCode":20,"cosmosGeoPoint":159,"geoPoint":163,"contacts":7},"Texas Children's Hosp \u002F Baylor Univ","Houston","Texas","77030",{"type":22,"coordinates":160},[161,162],-95.36327,29.76328,{"lat":162,"lon":161},{"facility":165,"status":7,"city":166,"state":7,"zip":167,"country":168,"countryCode":169,"cosmosGeoPoint":170,"geoPoint":174,"contacts":7},"San Juan City Hosp","San Juan","009367344","Puerto Rico","PR",{"type":22,"coordinates":171},[172,173],-66.10572,18.46633,{"lat":173,"lon":172},{"type":176,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR",[178],{"name":179,"class":6},"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","100059424","stopping-and-restarting-anti-hiv-drugs-in-children-and-adolescents-with-low-blood-levels-of-hiv-100059424",false,"NCT00016783","Stopping and Restarting Anti-HIV Drugs in Children and Adolescents With Low Blood Levels of HIV","Intensification of HIV-Specific CD4 and CD8 Activity by Cycling Highly Active Antiretroviral Therapy (HAART) in Pediatric\u002FAdolescent Patients With Less Than 50 HIV RNA Copies\u002Fml","Note: A Study Monitoring Committee (SMC) recommended on 06\u002F22\u002F05 that this study close, because the primary objectives in this proof-of-concept study could not be achieved. As of 06\u002F28\u002F05, Group A participants will discontinue their drug holiday cycles and will be given the best possible therapy. All participants in this study will have a final study visit to be scheduled as soon as possible, prior to 07\u002F29\u002F05.\n\nInclusion Criteria:\n\n* HIV infected\n* For Cohort 1, CD4 T-cell percent greater than 20\n* For Cohort 2, CD4 T-cell percent greater than 25\n* Viral load less than 400 copies\u002Fml in the year prior to study entry and less than 50 copies\u002Fml at screening\n* Taking anti-HIV drugs (including at least 1 protease inhibitor) and have been on anti-HIV drugs for at least 1 year prior to study entry\n* Have been on their current drug regimen for at least 4 months\n* Willing to follow study procedures\n* Parental or guardian consent if under 18 years old\n* Acceptable forms of contraception\n\nExclusion Criteria:\n\n* Taking abacavir, nevirapine, efavirenz, or delavirdine\n* AIDS-related or other infections needing drug treatment at study entry\n* Pregnant or breastfeeding\n* Have, or have had in the past, diseases (other than HIV infection) or other conditions that, in the doctor's opinion, would interfere with the study\n* Taking experimental drugs without the consent of the protocol team","ALL","2 Years","21 Years",{"count":191,"type":7},39,"OBSERVATIONAL","Some patients taking anti-HIV drugs as part of highly active antiretroviral therapy (HAART) do not show any HIV in the blood; however, some HIV will remain hidden in the body and, if the drugs are stopped, will return to the blood. The purpose of this study is to determine if short periods of stopping HAART increase the activity of CD8 and CD4 cells (cells of the immune system that fight infection), if repeated stopping of these drugs for longer periods of time and restarting them will increase effectiveness of HAART, and if the increased immune system activity as a result of stopping treatment leads to lower levels of HIV over time.",[195],"HIV Infections",[197,198,199,200,201,202,203,204,205,206,207],"Drug Therapy, Combination","Drug Administration Schedule","HIV Protease Inhibitors","CD4 Lymphocyte Count","CD8-Positive T-Lymphocytes","Reverse Transcriptase Inhibitors","Anti-HIV Agents","Viral Load","Antiretroviral Therapy, Highly Active","Treatment Experienced","Treatment Interruption","COMPLETED","2013-10-04",{"date":211,"type":212},"2013-10-07","ESTIMATED",{"date":214,"type":215},"2006-10","ACTUAL",{"name":5,"class":6},17]