[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100487062":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":29,"centralContacts":10,"locations":33,"responsibleParty":46,"collaborators":49,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":71,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":10,"studyType":78,"phases":10,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":86,"whyStopped":10,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"ETH Zurich","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Healthy participants",null,"Age of the participants is between 18-40 years, females and males equally distributed",[13,14,15],"Other: Elevated ambient heat","Other: Elevated relative humidity","Other: Exertion",[17,21,25],{"type":6,"name":18,"description":19,"armGroupLabels":20,"otherNames":10},"Elevated ambient heat","Temporary exposure to increased ambient temperature +10°C (the effect of the intervention is fully and spontaneously reversible)",[9],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"Elevated relative humidity","Temporary exposure to increased ambient relative humidity +40% (max. 90%) (the effect of the intervention is fully and spontaneously reversible)",[9],{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":10},"Exertion","Temporary exertion on an ergometer (1W\u002Fkg body weight) (the effect of the intervention is fully and spontaneously reversible)",[9],[30],{"name":31,"affiliation":5,"role":32},"Noé Brasier, MD","PRINCIPAL_INVESTIGATOR",[34],{"facility":5,"status":10,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":10},"Zurich","Andere (Nicht USA-Länder)","8093","Switzerland","CH",{"type":41,"coordinates":42},"Point",[43,44],8.55,47.36667,{"lat":44,"lon":43},{"type":32,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Noe Brasier","Principal Investigator",[50,53,55,57,59,61],{"name":51,"class":52},"Swiss Federal Office of Sports (BASPO)","UNKNOWN",{"name":54,"class":6},"University of Zurich",{"name":56,"class":52},"Center for Chronobiology, Psychiatric University Clinics, Basel",{"name":58,"class":52},"epyMetrics",{"name":60,"class":6},"Innosuisse - Swiss Innovation Agency",{"name":62,"class":52},"Swiss Federal Railways","100487062","the-detection-of-heat-stress-by-assessing-individual-body-responses-to-heat-heat-strain-in-young-and-healthy-non-athlete-participants-100487062",false,"NCT05622188","The Detection of Heat Stress by Assessing Individual Body Responses to Heat (Heat Strain) in Young and Healthy Non-athlete Participants","HEAT Stress Detection From Personally STandARdized Heat Strain Measurements - The HEATSTAR Pilot Trial","HEATSTAR","Inclusion Criteria:\n\n* Healthy participant, able to give consent\n* Age 18-40 years\n* Non-athlete (\\\u003C4h sport\u002Fweek)\n* BMI\\\u003C30 (non-obese)\n* German speaking, or fluent in German\n\nExclusion Criteria:\n\n* Pregnancy (urine pregnancy test), and breastfeeding\n* Regular medication intake (excluding birth control pill)\n* Intake of drugs and\u002For daily alcohol consumption\n* Fever or symptoms of an acute infection (cough, shortness of breath, sore throat, taste loss)\n* Active smoking or history of smoking \\\u003C9 months ago\n* Mobility impairment\n* Traveled (\\\u003C1 month ago) to a warm\u002Fhot temperature zone and stayed for \\>6 days\n* Any chronic conditions such as: high blood pressure, diabetes mellitus, immuno-deficiencies, sweat disorders such as anhidrosis\n* Color blindness (STROOP test)\n* Weight \\\u003C40 kg (e-Celsius pill)\n* Diverticulum or obstructions of the gastrointestinal tract (including motility disorders, swallowing disorders) as well as major abdominal surgery (e-Celsius pill)\n* Need of exposure to strong electromagnetic fields during study participation, above all MRI examinations (e-Celsius pill)",true,"ALL","18 Years","40 Years",{"count":76,"type":77},23,"ACTUAL","OBSERVATIONAL","• This study investigates and compares the within and in-between variances of the body responses to different heat stressors in a controlled lab-setting. The participants will be exposed to different heat sources while a variety of physiological heat strain reactions such as heartrate, sweat rate, and core body temperature are recorded using on- and in-body devices. For the participant monitoring during the study, medical grade devices such as a certified ECG and a swallowable sensor-pill to continuously monitor the core body temperature will be applied. A one-for-all wearable device is additionally applied for physiological validation. Further, sweat will be collected to assess (i) the local sweat rate and (ii) the appearance of different heat stress associated molecular markers in this non-invasively collectable biofluid. As a secondary aim, a model will be developed that will enable to predict the different heat stress sources out of the heat strain measurements.",[81],"Heat Stress",[83,84,85],"Heat Strain","Wearable","Sweat Analysis","COMPLETED","2023-02-10",{"date":89,"type":77},"2023-02-13",{"date":91,"type":77},"2022-11-02",{"date":87,"type":77},{"name":5,"class":6},1]