[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100354176":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":24,"locations":33,"responsibleParty":46,"collaborators":18,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":18,"eligibilityCriteria":54,"healthyVolunteers":51,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":18,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":18,"overallStatus":67,"whyStopped":18,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},{"fullName":5,"class":6},"Cairo University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"MgSO4","EXPERIMENTAL","The magnesium sulfate will be given according to the regimen of 6 grams intravenous over 20 minutes as a loading dose.",[13],"Drug: MgSO4",[15],{"type":16,"name":9,"description":11,"armGroupLabels":17,"otherNames":18},"DRUG",[9],null,[20],{"name":21,"affiliation":22,"role":23},"Ahmed Maged, MD","Professor","PRINCIPAL_INVESTIGATOR",[25,29],{"name":21,"role":26,"phone":27,"phoneExt":18,"email":28},"CONTACT","+201005227404","prof.ahmedmaged@gmail.com",{"name":30,"role":26,"phone":31,"phoneExt":18,"email":32},"Mohamed Elmahy, MD","01111831716","Mohamed.elmahy@kasralainy.edu.eg",[34],{"facility":35,"status":18,"city":36,"state":18,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":18},"Kasr Alainy medical school","Cairo","12151","Egypt","EG",{"type":41,"coordinates":42},"Point",[43,44],31.24967,30.06263,{"lat":44,"lon":43},{"type":23,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Ahmed M Maged, MD","Principal investigator","100354176","the-effect-of-loading-dose-of-magnesium-sulfate-on-uterine-umbilical-and-fetal-middle-cerebral-arteries-doppler-biophysical-profile-ctg-maternal-vital-signs-in-women-with-severe-preeclampsia-100354176",false,"NCT03891498","The Effect of Loading Dose of Magnesium Sulfate on Uterine, Umbilical, and Fetal Middle Cerebral Arteries Doppler, Biophysical Profile, CTG, Maternal Vital Signs in Women With Severe Preeclampsia","Inclusion Criteria:\n\n* Singleton pregnancy.\n* Primigravida or Multigravida.\n* Pregnant females ≥ 37 weeks of gestation.\n* Diagnosed as severe preeclampsia by the following criteria:\n\n  * Sustained systolic blood pressure of ≥160 mmHg or a sustained diastolic blood pressure of ≥ 110 mmHg.\n  * Proteinuria measured as +1 or more by dipstick or 24 hours urine collection with proteinuria ≥ 0.3 grams.\n  * Oliguria or creatinine \\> 1.1 mg%.\n  * Laboratory findings characteristic of HELLP syndrome.\n  * Symptoms suggestive of severe preeclampsia ; severe headache, blurring of vision, epigastric pain.\n\nExclusion Criteria:\n\n* Multifetal pregnancy.\n* History of epilepsy.\n* Patients with diabetes.\n* Patients with renal disease.\n* Fetuses with congenital anomalies.\n* Patients receiving anticoagulants e.g. heparin (unfractionated or low molecular weight).\n* Patients with severe IUGR.\n* Patients with accidental hemorrhage.","FEMALE","20 Years","40 Years",{"count":59,"type":60},100,"ESTIMATED","INTERVENTIONAL",[63],"NA","100 women with severe preeclanpsia received Magnesium sulfate 6 grams intravenous over 20 minutes as a loading dose. Resistance index \\[RI\\], pulsatility index \\[PI\\] and systolic\u002Fdiastolic \\[S\u002FD\\] ratio of the umbilical artery, uterine aryery and fetal middle cerebral artery before and repeated 20 minutes after intravenous administration of 6 grams of magnesium sulphate (loading dose) over 20 minutes . fetal breathing movements and fetal gross movements are counted within 20 minutes, before and after intravenous administration of 6 grams of magnesium sulphate (loading dose) over 20 minutes",[66],"Preeclampsia","UNKNOWN","2019-03-25",{"date":70,"type":71},"2019-03-27","ACTUAL",{"date":73,"type":60},"2019-03",{"date":75,"type":60},"2019-12",{"name":5,"class":6},1]