[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100385497":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":29,"centralContacts":22,"locations":33,"responsibleParty":45,"collaborators":22,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":22,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":22,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":68,"overallStatus":74,"whyStopped":22,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"Gazi University","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients with periodontitis and osteoporosis","EXPERIMENTAL","Group 1 : Patients who have periodontitis and osteoporosis prescribed with bisphosphonates",[13],"Procedure: non-surgical periodontal treatment",{"label":15,"type":10,"description":16,"interventionNames":17},"Systemically healthy patients with periodontitis","Group 2: Patients who have no systemic diseases but diagnosed as periodontitis",[13],{"label":19,"type":20,"description":21,"interventionNames":22},"Systemically and periodontally healthy individuals","NO_INTERVENTION","Group 3: Healthy controls",null,[24],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":22},"PROCEDURE","non-surgical periodontal treatment","supra- and subgingival scaling, and root planning",[9,15],[30],{"name":31,"affiliation":5,"role":32},"Basak Karasu","PRINCIPAL_INVESTIGATOR",[34],{"facility":5,"status":22,"city":35,"state":36,"zip":37,"country":38,"countryCode":22,"cosmosGeoPoint":39,"geoPoint":44,"contacts":22},"Ankara","Cankaya","06500","Turkey (Türkiye)",{"type":40,"coordinates":41},"Point",[42,43],32.85427,39.91987,{"lat":43,"lon":42},{"type":32,"investigatorFullName":31,"investigatorTitle":46,"investigatorAffiliation":5,"oldNameTitle":22,"oldOrganization":22},"Principal Investigator","100385497","the-effetcs-of-non-surgical-periodontal-treatment-on-salivary-biomarkers-of-patients-with-osteoporosis-and-periodontitis-100385497",false,"NCT04299477","THE EFFETCS OF NON-SURGICAL PERIODONTAL TREATMENT ON SALIVARY BIOMARKERS OF PATIENTS WITH OSTEOPOROSIS AND PERIODONTITIS","EVALUATION OF THE EFFETCS OF NON-SURGICAL PERIODONTAL TREATMENT ON SALIVARY BIOMARKERS OF PATIENTS UNDERGOING BISPHOSPHONATE THERAPY","Inclusion Criteria:\n\n* The participants were postmenopausal patients defined as absence of menstruation for at least 12 months.\n* Patients with periodontitis;\n* Patients who had no systemic diseases and were periodontally healthy (no attachment loss),\n* Patients who were treated with oral bisphosphonate at least one year (70 mg tablet once weekly)\n\nExclusion Criteria:\n\n* if they had received any periodontal treatment in the preceding three months,\n* if they were pregnant or in the period of lactation,\n* if they had systemic diseases that may interfere with normal healing mechanism,\n* if they had taken antibiotics, anticonvulsants, immunosuppressants, calcium channel blockers in the preceding six months.\n* Smokers",true,"FEMALE","35 Years","65 Years",{"count":59,"type":60},75,"ACTUAL","INTERVENTIONAL",[63],"NA","Inflammatory mediators in periodontitis may lead to elevated systemic cytokine levels, resulting in increased bone resorption including the jaws. Osteoporosis may have an influence on the periodontal condition of post-menopausal women and the risk for periodontal disease may increase due to osteoporosis. The hypothesis of the study was that non-surgical periodontal treatment and medical treatment of osteoporosis by bisphosphonates may improve the clinical outcomes and decrease salivary levels of IL-1β, IL-17, ALP and 8-OHdG. Therefore, the aim of this study was to evaluate the mechanism of bi-directional relationship between osteoporosis and periodontal diseases and to investigate the outcomes of non-surgical periodontal treatment with regard to salivary levels of IL-1β, IL-17, 8-OHdG and ALP in patients with periodontitis and osteoporosis.",[66,67],"Osteoporosis","Periodontitis",[26,69,70,71,72,73],"bisphosphonates","interleukin-1β","interleukin-17","8-hydroxydeoxyguanosine","alkaline phosphatase","COMPLETED","2020-03-05",{"date":77,"type":60},"2020-03-06",{"date":79,"type":60},"2018-06-30",{"date":81,"type":60},"2019-05-30",{"name":5,"class":6},1]