[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100604051":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":31,"locations":32,"responsibleParty":44,"collaborators":46,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":62,"eligibilityCriteria":63,"healthyVolunteers":58,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":31,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":31,"overallStatus":76,"whyStopped":31,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Apostolos Loukas Medical Centre Cyprus","NETWORK",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Olive oil aldehydic phenols (OOPs) supplement","EXPERIMENTAL","Participants receive a daily dose of 10 mg OOPs supplement (2 capsules, each containing 5 mg polyphenols). The formulation consists of 75% oleocanthal\u002Foleacein and 25% oleuropein aglycon\u002Fligstroside aglycon.",[13],"Dietary Supplement: Olive Oil Polyphenol Supplement (OOPs, OLEOPROTECT®, Thousand Olives®)",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo supplement","PLACEBO_COMPARATOR","Participants receive 2 placebo capsules daily, identical in weight, appearance, and taste to the active supplement. Placebo contains PEG400, cellulose, silicon dioxide, and magnesium stearate, but no active olive oil polyphenols.",[19],"Dietary Supplement: Placebo capsules",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIETARY_SUPPLEMENT","Olive Oil Polyphenol Supplement (OOPs, OLEOPROTECT®, Thousand Olives®)","Participants receive two capsules daily (total 10 mg\u002Fday) of a standardized olive oil polyphenol extract. Each capsule contains 5 mg of aldehydic phenols: 75% oleocanthal\u002Foleacein and 25% oleuropein aglycon\u002Fligstroside aglycon. Formulated with PEG400, cellulose, silicon dioxide, and magnesium stearate. Duration: 12 weeks.",[9],[9],{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"Placebo capsules","Two capsules taken daily for 12 weeks. Identical in weight, appearance, and taste to the active OOPs capsules. Contain PEG400, cellulose, silicon dioxide, and magnesium stearate, but no active olive oil polyphenols.",[15],null,[33],{"facility":5,"status":31,"city":34,"state":35,"zip":31,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":31},"Nicosia","Engomi","Cyprus","CY",{"type":39,"coordinates":40},"Point",[41,42],33.35397,35.17284,{"lat":42,"lon":41},{"type":45,"investigatorFullName":31,"investigatorTitle":31,"investigatorAffiliation":31,"oldNameTitle":31,"oldOrganization":31},"SPONSOR",[47,50,52,54],{"name":48,"class":49},"University of Nicosia","OTHER",{"name":51,"class":49},"University of Crete",{"name":53,"class":49},"National and Kapodistrian University of Athens",{"name":55,"class":49},"Yale University","100604051","the-impact-of-olive-oil-polyphenol-supplementation-on-metabolic-syndrome-parameters-preclinical-investigations-have-demonstrated-that-olive-oil-polyphenols-notably-oleocanthal-oleacein-and-allied-secoiridoids-possess-anti-inflammatory-and-antioxidant-attributes-100604051",false,"NCT07144488","The Impact of Olive Oil Polyphenol Supplementation on Metabolic Syndrome Parameters: Preclinical Investigations Have Demonstrated That Olive Oil Polyphenols, Notably Oleocanthal, Oleacein, and Allied Secoiridoids, Possess Anti-inflammatory and Antioxidant Attributes","The Impact of Olive Oil Polyphenol Supplementation on Metabolic Syndrome Parameters","OleoMetS","Inclusion Criteria:\n\n* Adults aged 30-70 years with a diagnosis of MetS per International Diabetes Federation criteria were enrolled after informed consent.\n\nExclusion Criteria:\n\n\\-","ALL","30 Years","70 Years",{"count":68,"type":69},106,"ACTUAL","INTERVENTIONAL",[72],"NA","Olive oil polyphenols, particularly oleocanthal, oleacein, and related secoiridoids, have shown anti-inflammatory and antioxidant properties in preclinical studies. Metabolic syndrome (MetS) is characterized by a constellation of risk factors, including central obesity, dyslipidemia, hypertension, and dysglycemia, which collectively contribute to a substantially elevated risk of cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). Preclinical investigations have demonstrated that olive oil polyphenols, notably oleocanthal, oleacein, and allied secoiridoids, possess anti-inflammatory and antioxidant attributes.\n\nThe goal of this clinical trial is to learn if a polyphenol-rich olive oil extract works to improve metabolic syndrome (MetS) parameters in adults. It will also evaluate the safety of the supplement. The main questions it aims to answer are:\n\nDoes the olive oil extract improve fasting blood glucose and HbA1c levels?\n\nHow does the supplement affect other health measures such as cholesterol levels, inflammation (CRP), body mass index (BMI), blood pressure, waist size, liver function (ALT), kidney function (eGFR), uric acid levels, and fatigue?\n\nResearchers will compare the olive oil extract supplement to a placebo (a look-alike substance with no active ingredients) to see if the supplement can help manage metabolic syndrome.\n\nParticipants will:\n\nTake either 10 mg of the olive oil extract supplement or a placebo once daily for 12 weeks\n\nAttend clinic visits for tests and checkups at the beginning and end of the study period\n\nHave their blood sugar, cholesterol, inflammation markers, liver and kidney function, and other health parameters measured before and after the treatment\n\nComplete questionnaires assessing fatigue levels",[75],"Metabolic Syndrome","COMPLETED","2025-08-25",{"date":79,"type":69},"2025-08-27",{"date":81,"type":69},"2024-09-01",{"date":83,"type":69},"2025-01-01",{"name":5,"class":6},1]