[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100070018":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":26,"centralContacts":41,"locations":48,"responsibleParty":76,"collaborators":78,"id":83,"slug":84,"hasResults":85,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":10,"eligibilityCriteria":89,"healthyVolunteers":90,"sex":91,"minAge":92,"maxAge":93,"enrollmentInfo":94,"targetDuration":10,"studyType":97,"phases":10,"briefSummary":98,"conditions":99,"keywords":100,"overallStatus":102,"whyStopped":10,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":10,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"Bayside Health","OTHER_GOV",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Cystic Fibrosis",null,"Patients with cystic fibrosis",[13,14],"Procedure: Physiotherapy, exercise, percutaneous gastrostomy feeds","Drug: Anti-reflux pharmacotherapy",{"label":16,"type":10,"description":10,"interventionNames":10},"Control",[18,22],{"type":19,"name":20,"description":10,"armGroupLabels":21,"otherNames":10},"PROCEDURE","Physiotherapy, exercise, percutaneous gastrostomy feeds",[9],{"type":23,"name":24,"description":10,"armGroupLabels":25,"otherNames":10},"DRUG","Anti-reflux pharmacotherapy",[9],[27,31,33,35,37,39],{"name":28,"affiliation":29,"role":30},"Brenda M Button, DPhty, PhD","The Alfred","PRINCIPAL_INVESTIGATOR",{"name":32,"affiliation":29,"role":30},"Susannah King",{"name":34,"affiliation":29,"role":30},"Colleen Ash",{"name":36,"affiliation":29,"role":30},"John W Wilson, MBBS, PhD",{"name":38,"affiliation":29,"role":30},"Greg Snell, MBBS",{"name":40,"affiliation":29,"role":30},"Stuart Roberts, MBBS",[42],{"name":43,"role":44,"phone":45,"phoneExt":46,"email":47},"Brenda M. Button, DPhty, PhD","CONTACT","9276 2000","3450","b.button@alfred.org.au",[49],{"facility":50,"status":51,"city":52,"state":53,"zip":54,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"The Alfred Hospital","RECRUITING","Melbourne","Victoria","3004","Australia","AU",{"type":58,"coordinates":59},"Point",[60,61],144.96332,-37.814,{"lat":61,"lon":60},[64,65,68,70,72,73,74,75],{"name":28,"role":44,"phone":45,"phoneExt":46,"email":47},{"name":36,"role":44,"phone":45,"phoneExt":66,"email":67},"3600","john.wilson@med.monash.edu.au",{"name":69,"role":30,"phone":10,"phoneExt":10,"email":10},"Brenda M Button, DPhty,PhD",{"name":32,"role":71,"phone":10,"phoneExt":10,"email":10},"SUB_INVESTIGATOR",{"name":34,"role":71,"phone":10,"phoneExt":10,"email":10},{"name":36,"role":71,"phone":10,"phoneExt":10,"email":10},{"name":38,"role":71,"phone":10,"phoneExt":10,"email":10},{"name":40,"role":71,"phone":10,"phoneExt":10,"email":10},{"type":77,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[79,81],{"name":29,"class":80},"OTHER",{"name":82,"class":80},"Monash University","100070018","the-prevalence-and-significance-of-gastro-oesophageal-reflux-in-cystic-fibrosis-before-and-after-lung-transplantation-100070018",false,"NCT00164021","The Prevalence and Significance of Gastro-oesophageal Reflux in Cystic Fibrosis Before and After Lung Transplantation","The Prevalence and Significance of Gastro-oesophageal Reflux in Adults With Cystic Fibrosis Before and After Lung Transplantation, Together With the Effects of Physiotherapy Airway Clearance Techniques on Gastro-oesophageal Function","Inclusion Criteria:\n\n* \\* Diagnosis of cystic fibrosis\n\n  * Medically stable\n\nExclusion Criteria:\n\n* \\* Known oesophageal varices",true,"ALL","16 Years","70 Years",{"count":95,"type":96},180,"ESTIMATED","OBSERVATIONAL","Gastro-oesophageal reflux (GOR) has been found to be prevalent in children with cystic fibrosis (CF)and may further worsen lung damage via reflex bronchospasm or pulmonary aspiration. Chest physiotherapy may result in increased episodes of GOR as demonstrated in children. Lung transplantation may worsen pre-existing GOR. This study will determine the prevalence, severity and significance of symptomatic and silent GOR in adults with CF before and after lung transplant using 24hr oesophageal pH monitoring, a valid symptom questionnaire, quality of life questionnaires and gastric emptying studies. This study will identify the extent of GOR in a large adult CF population and the impact on lung function and quality of life together with the effects of medical and physiotherapy treatment on gastro-oesophageal function.",[9],[101],"gastroesophageal reflux, gastric reflux, acid reflux, lung transplantation, physiotherapy, anti-reflux medication","UNKNOWN","2016-01-13",{"date":105,"type":96},"2016-01-15",{"date":107,"type":10},"2001-02",{"name":5,"class":6},1]