[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100310843":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":32,"centralContacts":31,"locations":36,"responsibleParty":48,"collaborators":52,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":64,"acronym":31,"eligibilityCriteria":65,"healthyVolunteers":66,"sex":67,"minAge":68,"maxAge":31,"enrollmentInfo":69,"targetDuration":31,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":78,"overallStatus":81,"whyStopped":31,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Norwegian School of Sport Sciences","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Strength training + protein supplement","EXPERIMENTAL","Two sessions of strength training each week in addition to daily protein supplementation for 10 weeks.",[13,14],"Other: Strength training","Dietary Supplement: Protein supplementation",{"label":16,"type":10,"description":17,"interventionNames":18},"Protein supplement","Daily protein supplementation for 10 weeks.",[14],[20,26],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"Strength training","Heavy load strength training performed twice a week for 10 weeks.",[9],[25],"Resistance training",{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"DIETARY_SUPPLEMENT","Protein supplementation","Dietary protein supplement (protein-enriched milk with 0,2 % fat). 0,33 l each day for 10 weeks.",[16,9],null,[33],{"name":34,"affiliation":5,"role":35},"Truls Raastad, Prof.","PRINCIPAL_INVESTIGATOR",[37],{"facility":5,"status":31,"city":38,"state":31,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":31},"Oslo","0863","Norway","NO",{"type":43,"coordinates":44},"Point",[45,46],10.74609,59.91273,{"lat":46,"lon":45},{"type":49,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"SPONSOR_INVESTIGATOR","Truls Raastad","Prof.",[53,55,57],{"name":54,"class":6},"University of Padova",{"name":56,"class":6},"University of Copenhagen",{"name":58,"class":59},"Tine","INDUSTRY","100310843","the-role-of-muscle-protein-breakdown-in-the-regulation-of-muscle-quality-in-frail-elderly-individuals-100310843",false,"NCT03326648","The Role of Muscle Protein Breakdown in the Regulation of Muscle Quality in Frail Elderly Individuals","Inclusion Criteria:\n\n* Age \\> 65\n* Frail or pre-frail according to the Fried Frailty Criteria or Short Physical Performance Battery (SPPB) score \\\u003C6.\n* Mini Mental State Examination score \\> 18\n\nExclusion Criteria:\n\n* Diseases or injuries contraindicating participation\n* Lactose intolerance\n* Allergy to milk\n* Allergy towards local anesthetics (xylocain)\n* Use of anticoagulants that cannot be discontinued prior to the muscle biopsy",true,"ALL","65 Years",{"count":70,"type":71},34,"ACTUAL","INTERVENTIONAL",[74],"NA","The purpose of this study is to investigate mechanisms underlying the reduction in muscle quality (the ratio between muscle strength and muscle size) with aging, and to investigate how these factors are affected by strength training and protein supplementation. It is already established that muscle quality defined as the ratio between the strength and the size of a muscle is improved with strength training, even in frail elderly individuals. However, the relative contribution of factors such as activation level, fat infiltration, muscle architecture and single fiber function is unknown. The main focus of this study is to investigate the relationship between muscle quality and muscle protein breakdown, as insufficient degradation of proteins is hypothesized to negatively affect muscle quality.",[77],"Sarcopenia",[77,79,21,80],"Frailty","Autophagy","COMPLETED","2018-04-10",{"date":84,"type":71},"2018-04-11",{"date":86,"type":71},"2016-09-01",{"date":88,"type":71},"2018-03-01",{"name":50,"class":6},1]