[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100574137":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":20,"locations":26,"responsibleParty":44,"collaborators":10,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":10,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":54,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":10,"studyType":60,"phases":10,"briefSummary":61,"conditions":62,"keywords":65,"overallStatus":29,"whyStopped":10,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"Ain Shams University","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Healthy Subjects with Periodontitis",null,"Description: This group consists of 50 systemically healthy individuals diagnosed with periodontitis. Participants are of both genders, aged between 30 and 60 years. They have Periodontitis stage II and\u002For stage III and do not have any history of systemic diseases or long-term medication use. All smokers were excluded from this group.\n\nInterventions of Interest:\n\nClinical assessment of periodontal parameters such as Plaque Index (PI), Gingival Index (GI), Probing Depth (PD), and Clinical Attachment Level (CAL) using standard methods.\n\nEvaluation of the proportion of bleeding sites as a Bleeding on Probing (BOP) score.",{"label":13,"type":10,"description":14,"interventionNames":10},"ESRD Patients with Periodontitis","Description: This group includes 50 individuals diagnosed with end-stage renal disease (ESRD) who are on regular hemodialysis. Participants are of both genders, aged between 30 and 60 years, and unrelated Egyptians from similar socioeconomic statuses residing in the same geographical area. They also suffer from Periodontitis stage II and\u002For stage III. All participants have underlying type 2 diabetes mellitus. Exclusions include those with kidney transplants, other systemic diseases except diabetes, history of malignancy, and smokers.\n\nInterventions of Interest:\n\nClinical assessment of periodontal parameters similar to Group I, including PI, GI, PD, and CAL.\n\nAnalysis of genetic variations in the TLR4 gene through blood sample collection and DNA extraction.\n\nSNP genotyping in the TLR4 gene performed using Real Time Polymerase Chain Reaction (RT-PCR).",[16],{"name":17,"affiliation":18,"role":19},"Fatma E. A. Hassanein, PHD","king Salman Intwenational University University","PRINCIPAL_INVESTIGATOR",[21],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},"Asmaa Bakr elshaf3y, PHD","CONTACT","01000093885","Asmaa.AbdAlRaouf@gu.edu.eg",[27],{"facility":28,"status":29,"city":30,"state":31,"zip":10,"country":32,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"hemodialysis center at Benha University Hospital.","RECRUITING","Al Fayyum","Faiyum Governorate","Egypt","EG",{"type":35,"coordinates":36},"Point",[37,38],30.8418,29.30995,{"lat":38,"lon":37},[41],{"name":42,"role":23,"phone":24,"phoneExt":10,"email":43},"Nermeen Nagi assistant lecturer of Fixed Prosthodontics, Faculty of Dentis, msc","dr.nermeennagi@hotmail.com",{"type":19,"investigatorFullName":45,"investigatorTitle":46,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Fatma ElSayed","assistant professor","100574137","the-role-of-toll-like-receptor-4-in-periodontitis-patients-with-end-stage-renal-disease-in-a-sample-of-egyptian-population-100574137",false,"NCT06755372","The Role of Toll-like Receptor-4 in Periodontitis Patients With End-stage Renal Disease in a Sample of Egyptian Population","Group I: Healthy Subjects with Periodontitis\n\nInclusion Criteria:\n\nAge: 30 to 60 years\n\nGender: Both male and female\n\nDiagnosed with Periodontitis stage II and\u002For stage III\n\nSystemically healthy, no history of systemic diseases\n\nNot on long-term medications\n\nExclusion Criteria:\n\nSmokers\n\nIndividuals with any systemic disease or long-term medication use\n\nGroup II: ESRD Patients with Periodontitis\n\nInclusion Criteria:\n\nAge: 30 to 60 years\n\nGender: Both male and female\n\nDiagnosed with end-stage renal disease (ESRD) on regular hemodialysis\n\nDiagnosed with Periodontitis stage II and\u002For stage III\n\nUnrelated Egyptians from a similar socioeconomic status, residing in the same geographical area\n\nUnderlying type 2 diabetes mellitus\n\nExclusion Criteria:\n\nIndividuals with kidney transplants\n\nIndividuals with systemic diseases other than diabetes\n\nHistory of malignancy\n\nSmokers",true,"ALL","30 Years","60 Years",{"count":58,"type":59},100,"ESTIMATED","OBSERVATIONAL","Chronic kidney disease (CKD) is a significant public health issue in Egypt, leading to end-stage renal disease (ESRD). ESRD patients often suffer from oral abnormalities due to the disease and medications. Periodontitis is linked to systemic diseases, including renal disease, with inflammation playing a key role. TLR4 genetic variations may influence susceptibility to CKD and periodontitis. This study investigates the association between TLR4 \\[Gly\u002FThr (rs2149356)\\] polymorphism and chronic periodontal disease in ESRD patients in Egypt.",[63,64],"Periodontitis","End-stage Renal Disease",[66,67,63,68,69],"Chronic Kidney Disease","End-Stage Renal Disease","Toll-like Receptor 4","Genetic Polymorphism","2025-07-03",{"date":72,"type":73},"2025-07-04","ACTUAL",{"date":75,"type":73},"2025-04-01",{"date":77,"type":59},"2025-08-01",{"name":5,"class":6},1]