[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100245027":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":31,"centralContacts":11,"locations":36,"responsibleParty":49,"collaborators":11,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":11,"eligibilityCriteria":57,"healthyVolunteers":53,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":11,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":11,"overallStatus":70,"whyStopped":11,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"Institute of Liver and Biliary Sciences, India","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Noradrenaline + low dose terlipressin","EXPERIMENTAL",null,[13,14],"Drug: Low dose terlipressin","Drug: Noradrenaline",{"label":16,"type":17,"description":11,"interventionNames":18},"Noradrenaline","ACTIVE_COMPARATOR",[14],[20,25,28],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"DRUG","Low dose terlipressin","Terlipressin-2mg (low dose )",[9],{"type":21,"name":16,"description":26,"armGroupLabels":27,"otherNames":11},"Noradrenaline at 7.5 mcg\u002Fmin, maximum of 60mcg\u002Fmin. stepped up every 15 min",[9],{"type":21,"name":16,"description":29,"armGroupLabels":30,"otherNames":11},"Noradrenaline- 3.75 mcg\u002Fmin to 30 mcg\u002Fmin. stepped up every 15 min",[16],[32],{"name":33,"affiliation":34,"role":35},"Vikash Prakash, MD","Institute of Liver and Biliary Sciences","PRINCIPAL_INVESTIGATOR",[37],{"facility":34,"status":11,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":11},"New Delhi","National Capital Territory of Delhi","110070","India","IN",{"type":44,"coordinates":45},"Point",[46,47],77.2148,28.62137,{"lat":47,"lon":46},{"type":50,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100245027","to-assess-the-efficacy-of-early-introduction-of-a-combination-of-low-dose-vasopressin-analogue-in-addition-to-noradrenaline-as-a-vasopressor-in-patients-of-cirrhosis-with-septic-shock-100245027",false,"NCT02468063","To Assess the Efficacy of Early Introduction of a Combination of Low Dose Vasopressin Analogue in Addition to Noradrenaline as a Vasopressor in Patients of Cirrhosis With Septic Shock","A Prospective Study to Assess the Efficacy of Early Introduction of a Combination of Low Dose Vasopressin Analogue in Addition to Noradrenaline as a Vasopressor in Patients of Cirrhosis With Septic Shock","Inclusion Criteria:\n\n* 18-70 yr\n* Cirrhosis with septic shock not responding to fluid resuscitation within 2 hrs.\n\nExclusion Criteria:\n\n* ECG (ElectroCardiography)changes at presentation which exclude the use of vasopressin analouges\n* Cardiac dysfunction ( valvular heart disease, coronary artery disease)\n* Acute mesenteric ischemia (confirmed or suspected) or vasospastic diathesis (e.g. Reynaud's syndrome or related diseases).\n* Pregnancy\n* Acute GI bleed\n* No Consent","ALL","18 Years","70 Years",{"count":62,"type":63},184,"ACTUAL","INTERVENTIONAL",[66],"NA","The consecutive patients admitted to Intensive care unit of Hepatology department of ILBS and full filling all the eligibility criteria will be enrolled in 1:1 ration by the process of randomization.- The study is an open level study. The investigators will strictly follow the randomization table to give therapy as per the intervention arm.\n\n* Intervention:-the therapeutic intervention is vasopressor i.e. noradrenaline alone and terlipressin along with noradrenaline to maintain the MAP \\>65mm Hg.\n* Intervention arm\n\n  * Arm (A) - Noradrenaline\n  * Arm (B) - Noradrenaline + low dose terlipressin",[69],"Cirrhosis With Septic Shock","COMPLETED","2017-11-02",{"date":73,"type":63},"2017-11-06",{"date":75,"type":63},"2015-05-01",{"date":77,"type":63},"2017-05-31",{"name":5,"class":6},1]