[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100371652":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":13,"locations":19,"responsibleParty":33,"collaborators":7,"id":35,"slug":36,"hasResults":37,"nctId":38,"briefTitle":39,"officialTitle":40,"acronym":7,"eligibilityCriteria":41,"healthyVolunteers":42,"sex":43,"minAge":44,"maxAge":7,"enrollmentInfo":45,"targetDuration":7,"studyType":48,"phases":7,"briefSummary":49,"conditions":50,"keywords":54,"overallStatus":57,"whyStopped":7,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":67},{"fullName":5,"class":6},"Chang Gung Memorial Hospital","OTHER",null,[9],{"name":10,"affiliation":11,"role":12},"Shao-Wen Weng, MD\u002FPhD","Assistant Professor of Chang Gung University","PRINCIPAL_INVESTIGATOR",[14],{"name":15,"role":16,"phone":17,"phoneExt":7,"email":18},"Wen-Chieh Chen, MD","CONTACT","886-972-833-798","chingjing@cgmh.org.tw",[20],{"facility":5,"status":21,"city":22,"state":7,"zip":7,"country":23,"countryCode":24,"cosmosGeoPoint":25,"geoPoint":30,"contacts":31},"RECRUITING","Kaohsiung City","Taiwan","TW",{"type":26,"coordinates":27},"Point",[28,29],120.31333,22.61626,{"lat":29,"lon":28},[32],{"name":15,"role":16,"phone":17,"phoneExt":7,"email":18},{"type":34,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100371652","use-of-gdf15-as-a-biomarker-for-early-diagnosis-of-dm-and-monitoring-of-progress-of-complications-in-asians-100371652",false,"NCT04119167","Use of GDF15 as a Biomarker for Early Diagnosis of DM and Monitoring of Progress of Complications in Asians","Use of Growth Differentiation Factor 15 as a Biomarker for Early Diagnosis of Diabetes Mellitus and Monitoring of Progress of Diabetic Peripheral Neuropathy in Asians","Inclusion Criteria:\n\n* adult participants with age \\>20, with pre-DM or DM as the study group and participants without hyperglycemia as the control group\n\nExclusion Criteria:\n\n* Pregnant woman or who is under breastfeeding\n* Who is difficult to understand or sign the informed consent\n* With coagulopathy or hematologic disease",true,"ALL","20 Years",{"count":46,"type":47},500,"ESTIMATED","OBSERVATIONAL","Significant differences in the expression of individual Growth Differentiation Factor 15 (GDF-15) proteins among Taiwanese harboring different mitochondrial genotypes are noted, and their blood serum levels also exhibited associations with diabetes. GDF-15 was originally discovered as an autocrine regulator of macrophage activation and shown to play important roles in fibrosis, malignancy, cardiovascular disease, glycemic control, and obesity. However, the relationship between GDF-15 and pre-diabetes and diabetes in Asian populations has yet to be fully investigated. Besides, any indirect associations between GDF-15 levels and diabetic complications remain unclear. The investigators aim to further investigate the role of GDF-15 levels in the initial diagnosis of diabetes, the monitoring of medication effectiveness and disease progression, and related complications such as diabetic nephropathy and neuropathy. The DNA isolated from the blood samples will be evaluated to determine individual mitochondria haplogroups, including variants located within the coding and control regions of the mitochondrial genome.",[51,52,53],"Diabetes Mellitus, Type 2","Diabetic Polyneuropathy","Diabetic Nephropathies",[51,52,55,56],"Diabetic Nephropathy","Growth Differentiation Factor 15","UNKNOWN","2019-10-05",{"date":60,"type":61},"2019-10-08","ACTUAL",{"date":63,"type":61},"2019-08-01",{"date":65,"type":47},"2021-10-30",{"name":5,"class":6},1]