[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Davidzon, Guido, M.D.\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":68},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":4},"100652081","early-phase-1-s1r-imaging-based-cryoneurolysis-in-chronic-pain-100652081",false,"NCT07768501","S1R Imaging-Based Cryoneurolysis in Chronic Pain","Molecular Imaging-Based Cryoneurolysis: Targeting Upregulated Sigma-1 Receptor Positive Nerves in Chronic Pain","Inclusion Criteria:\n\n1. Chronic nociceptive, neuropathic, or mixed pain for ≥2 months\n2. Pain originating from a region amenable to cryoneurolysis (celiac plexus, intercostal nerves, pudendal nerve, peripheral nerve block\n3. Chronic pain ≥2 months\n4. Pain score ≥4\u002F10\n5. Pain location amenable to cryoneurolysis\n6. Willing and able to provide consent.\n\nExclusion Criteria:\n\n1. Pregnancy or nursing.\n2. Non-English speaking individuals\n3. Contraindication to MRI scanning which includes, but is not limited to, incompatible metal or hardware including pacemakers, cochlear implants, and bullets near a critical organ.\n4. Weight \\>350 pounds or a large body habitus, which the MR scanner cannot accommodate.\n5. Claustrophobia or feeling that he or she will be unable to lie still in the scanner for a period of 2 hours or fit in the PET\u002FMR scanner due to body size.","ALL","18 Years",{"count":19,"type":20},6,"ESTIMATED","INTERVENTIONAL",[23],"EARLY_PHASE1","The goal of this clinical trial is to determine whether a sigma-1 receptor PET\u002FMRI scan can help identify the specific nerves responsible for chronic pain.\n\nResearchers will use an investigational imaging agent called \\[18F\\]FTC-146 to look for signs of pain generating nerve irritation or injury that may not be visible on convention imaging tests.\n\nParticipants whose pain-generating nerve can be identified may undergo a diagnostic nerve block and, if successful, a standard clinical procedure called cryoneurolysis will be used to temporarily interrupt pain signals.",[26,27],"Chronic Pain","Mixed Pain (Nociceptive and Neuropathic)",[29,30,31],"chronic pain","PET\u002FMRI","cryoneurolysis","NOT_YET_RECRUITING","2026-08-12",{"date":35,"type":36},"2026-08-17","ACTUAL",{"date":38,"type":20},"2026-09",{"date":40,"type":20},"2030-09",{"name":42,"class":43},"Davidzon, Guido, M.D.","OTHER",{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":50,"sex":16,"minAge":17,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":21,"phases":54,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":5},"100365483","phase-1-imaging-synapses-with-11c-ucb-j-in-the-human-brain-100365483","NCT04038840","Imaging Synapses With [11C] UCB-J in the Human Brain","Inclusion Criteria:\n\n* 18 - 65 years in age\n* For SZ participants:\n\n  * On a stable medication regimen for at least two weeks prior to testing\n  * A clinical diagnosis of schizophrenia, schizophreniform, or schizoaffective disorder\n  * Able to complete a PET-MR scan without the use of sedation\n\nExclusion Criteria:\n\n* Active substance use within three months of testing\n* IQ \\\u003C 70\n* Major medical neurological illness or significant head trauma\n* Pregnancy or breastfeeding\n* Contraindication to MR scanning, including magnetic-resonance incompatible metal or hardware including pacemakers, cochlear implants, and bullets near a critical organ\n* Weight \\> 350 lbs or a large body habitus that MR scanner cannot accommodate\n* History of or current claustrophobia\n* Inability to comply with basic study requirements such as following directions and punctuality\n* For HC participants:\n\n  * Presence of a first degree relative with a psychotic disorder\n  * Lifetime diagnosis of major psychiatric illness\n* For SZ participants:\n\n  * Unstable psychiatric symptoms at the time of testing, e.g. acute suicidality, prominent psychosis, or behavioral dyscontrol",true,"65 Years",{"count":53,"type":20},60,[55],"PHASE1","The purpose of this study is to utilize the radioactive positron emission tomography (PET) tracer \\[11C\\]UCB-J to test the neural synaptic pruning hypothesis of schizophrenia. This imaging method allows for the quantification of synaptic density in the living human brain and has the unprecedented ability to directly examine the synaptic pathology underlying neuropsychiatric disease. The neural synaptic pruning hypothesis posits that a key pathogenic process of schizophrenia is the over-exuberant elimination of neural synapses during development. The confirmation of reduced synaptic density in schizophrenia as evidenced by \\[11C\\]UCB-J has the potential to lead to a number of ground-breaking clinical innovations, such as laboratory-based diagnostics and prognostics, and novel, disease-modifying treatments.",[58],"Schizophrenia","RECRUITING","2024-12-11",{"date":62,"type":36},"2024-12-16",{"date":64,"type":36},"2019-08-01",{"date":66,"type":20},"2025-12",{"name":42,"class":43},""]