[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acid-base-disturbance\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acid-base-disturbance":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":5},"100653015","bicarbonate-variation-monitoring-with-indirect-calorimetry-100653015",false,"NCT07782658","Bicarbonate Variation Monitoring With Indirect Calorimetry","BICARbonate and Indirect Calorimetry Correlation in Critical Care","BICAR-CC","Inclusion Criteria:\n\n* Adult patient admitted to the ICU within the past 72 hours\n* Receiving invasive mechanical ventilation\n* For whom the treating clinician plans to perform at least two blood bicarbonate measurements within the next 6 hours\n* No objection from the participant or their next of kin\n\nExclusion Criteria:\n\n* Planned weaning from invasive mechanical ventilation or ventilator change before the second bicarbonate measurement\n* Conditions interfering with the interpretation of indirect calorimetry data:\n\n  * Inspiratory oxygen fraction \\> 60%\n  * Administration of inhaled medications, including nitric oxide\n  * Positive end-expiratory pressure (PEEP) \\> 15 cmH₂O\n  * Excessive leaks in the ventilator circuit, defined as expired volume \\\u003C 95% of inspired volume\n  * Patient on mechanical circulatory support with a gas exchanger, or planned initiation before the second blood gas analysis\n  * Patient on extracorporeal renal replacement therapy, or planned initiation before the second bicarbonate measurement\n  * Patient who received sodium bicarbonate within 2 hours prior to inclusion, or planned administration before the second bicarbonate measurement\n  * Frequent disconnections of the ventilator circuit, or planned bronchoscopy before the second bicarbonate measurement","ALL","18 Years",{"count":20,"type":21},91,"ESTIMATED","OBSERVATIONAL","Patients admitted to the intensive care unit frequently exhibit abnormal blood bicarbonate levels. These abnormalities are associated with patient outcomes and often prompt clinicians to modify management, either diagnostically or therapeutically (e.g., initiation or adjustment of mechanical ventilation, initiation or modification of extracorporeal renal replacement therapy, administration of specific diuretics, or sodium bicarbonate infusion).\n\nCurrently, the only way to determine blood bicarbonate concentration is through repeated blood sampling for laboratory analysis. However, this method is both discontinuous and invasive.\n\nWe have generated an in silico hypothesis suggesting that the mismatch between cellular CO₂ production\u002Felimination and pulmonary CO₂ elimination reflects changes in blood bicarbonate levels. We propose to test this hypothesis in a cohort of intensive care unit patients.\n\nIf confirmed, indirect calorimetry could be positioned as a continuous, non-invasive monitoring tool for blood bicarbonate.",[25,26,27],"Critically Ill Patients","Acid-Base Disturbance","Indirect Calorimetry",[29,30,31],"Bicarbonate","Acid-Base disturbance","Indirect calorimetry","NOT_YET_RECRUITING","2026-08-20",{"date":35,"type":36},"2026-08-24","ACTUAL",{"date":38,"type":21},"2026-11-01",{"date":40,"type":21},"2027-11-01",{"name":42,"class":43},"Hospices Civils de Lyon","OTHER"]